Results 51 to 60 of about 105,306 (266)

Effect of end-expiratory carbon dioxide monitoring on painless colonoscopy procedures in obstructive sleep apnea patients

Perioperative Medicine
Background Carbon dioxide (CO2) accumulation during prolonged painless colonoscopy procedures in patients with obstructive sleep apnea syndrome (OSAS) can lead to an increased incidence of various complications.
Pengxia Wang, Qiuxiang Jiang, Kaihui Li, Yinying Zeng, Zhangxing Chen, Shanshan Liu   +5 more
doaj   +1 more source

Effect of Participatory Health Promotion Initiative on Tobacco Use among Adolescents: A School-Based Quasi-Experimental Pilot Study from Central India

Social Health and Behavior, 2019
Introduction: Prevalence of noncommunicable diseases (NCDs) is increasing rapidly in developing countries like India. The commonly attributable modifiable risk factors of NCDs include raised blood pressure (13%), tobacco use (9%), physical inactivity (6%)
Shrinidhi S Datar, Priyadarsh Ture, Abhishek V Raut, White Coat Army Students Author Group   +3 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Development of a vasopressor control module for testing hemorrhagic shock resuscitation controllers

BioMedical Engineering OnLine
Introduction Patients in hemorrhagic shock who are unresponsive to fluid administration can potentially benefit from and may even require vasopressor therapy.
David Berard, Michael D. Lopez, Austin Ruiz, Jonathan Marrero Bermudez, Rachel Gathright, Tina M. Rodgers, Sofia I. Hernandez Torres, Caroline Gusson Shimoura, Evan Ross, Eric J. Snider   +9 more
doaj   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Trends and future projections of the disease burden of pulmonary arterial Hypertension–related heart failure in China and G20 countries: Based on the global burden of disease 2023 database

International Journal of Cardiology. Cardiovascular Risk and Prevention
Objectives: While the Global Burden of Disease (GBD) study has extensively assessed various cardiovascular conditions, the epidemiological profile of pulmonary arterial hypertension-related heart failure (PAH-HF) across the G20 remains uncharacterized ...
Peixun He, Yanming Liu, Wei Zeng, Yi Sun, Yan Wang, Xueyong Li, Weinan Zhao   +6 more
doaj   +1 more source

Nagata Tetsuzan and the Manchurian incident

Journal of Human Environmental Studies, 2008
Nagata Tetsuzan is known as one of the leading figures of the Imperial Army after the Manchurian incident. However, the full- scale research on him has not been done yet.
Minoru Kawada
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury.
Tao Liu, Jingtong Li, Xiaoxuan Hu, Jinyuan Tang, Yuxu Zhong, Xin Shu, Xiao-ji Zhu   +6 more
doaj   +1 more source