Results 61 to 70 of about 15,388,388 (297)
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Report on the Bombing of Our Own Troops during Operation “Tractable”: 14 August 1944 [PDF]
, 2012 Editor’s Note: Operation “Tractable“ was the second major Canadian operation in Normandy designed to break through the German defensive perimeter to reach Falaise.
Harris, Arthur T.
core +1 more source
Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes
Advanced Science, EarlyView.Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan +8 more
wiley +1 more source
Perioperative MedicineBackground Carbon dioxide (CO2) accumulation during prolonged painless colonoscopy procedures in patients with obstructive sleep apnea syndrome (OSAS) can lead to an increased incidence of various complications.
Pengxia Wang +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu +20 more
wiley +1 more source
Development of a vasopressor control module for testing hemorrhagic shock resuscitation controllers
BioMedical Engineering OnLineIntroduction Patients in hemorrhagic shock who are unresponsive to fluid administration can potentially benefit from and may even require vasopressor therapy.
David Berard +9 more
doaj +1 more source
Expressions of apoptotic protein and gene following sulfur mustard-induced acute pulmonary injuries in rats [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Pathomechanisms of sulfur mustard (SM) are not fully understood, and no specific medical countermeasures exist to prevent SM-induced pulmonary injury.
Tao Liu +6 more
doaj +1 more source
Inland Navigation Technology \u2709 - Digital Technology Impact on Safety and Efficiency [PDF]
, 2009 This workshop discussed the impact of digital technology on inland navigation safety and efficiency from the combined perspective government agencies and waterway operators.
Alexander, Lee
core +1 more source
Advanced Science, EarlyView.This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin +12 more
wiley +1 more source
“The Battle-Fortune of Marshal Hindenburg is not Bound up with the Possession of a Hill”: The Germans and Vimy Ridge, April 1917 [PDF]
, 2016 On 9 April 1917 four Canadian divisions and one British division of 170,000 men broke through the “Vimy Group” of German Sixth Army of some 40,000 men. By late afternoon, the Germans had been driven off the Ridge. That day, as Brigadier-General Alexander
Herwig, Holger
core +1 more source