Results 161 to 170 of about 15,592 (277)

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Au42(PET)32 Nanocluster Sensitizer Unlocks the Annihilator Potential of Rubrene, Enabling High‐Performance NIR‐to‐Visible Photon Upconversion

Angewandte Chemie, EarlyView.
A needle‐shaped gold nanocluster, Au42(PET)32, serves as a powerful triplet sensitizer, enabling rubrene to fully express its intrinsic annihilator capability (spin statistical factor f = 0.58). This sensitizer–annihilator pair achieves record‐high upconversion internal quantum yields of 21.4% (808 nm excitation) and 15.0% (936 nm excitation ...
Masaaki Mitsui, Shinjiro Takano, Tatsuya Tsukuda   +2 more
wiley   +2 more sources

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Nucleoside‐Based Hydrogel Platform Synergizes with Photothermal Effects for Enhanced Biofilm Eradication Against Periodontitis

Advanced Science, EarlyView.
A synergistic antibiofilm hydrogel platform (ZBAg@FNP) is developed by encapsulating an organic small‐molecule photothermal agent (FNP) within a silver ion‐mediated supramolecular hydrogel (ZBAg), enabling photothermal disruption of biofilm integrity and controlled Ag⁺ ion release upon irradiation.
Yinghui Wen, Yunfei Li, Tiannan Liu, Chongkui Sun, Hang Zhao, Yao Yuan, Shiping Yang, Tingxing Zhao, Jiang Liu   +8 more
wiley   +1 more source

Advances in Thermoelectric Thin Films Grown by Atomic Layer Deposition: A Critical Review of Performance and Challenges

Advanced Energy Materials, EarlyView.
This review highlights the use of atomic layer deposition (ALD) for fabricating thermoelectric thin films with atomic‐scale control. Four material classes—chalcogenides, doped oxides, ternary oxides, and multilayered structures—are compared in terms of growth dynamics, structure–property relationships, and thermoelectric performance. The precise tuning
Jorge Luis Vazquez‐Arce, Dong‐Ho Shin, Shuyue Yao, Shiyang He, Kornelius Nielsch, Amin Bahrami   +5 more
wiley   +1 more source

Application of gas chromatography on the evaluation of grape and wine aroma in atlantic viticulture (NW iberian peninsula) [PDF]

, 2012
Oliveira, J. M., Vilanova, Mar
core   +1 more source

Biomarker‐Agnostic Detection of Ovarian Cancer from Blood Plasma Using a Machine Learning‐Driven Electronic Nose

Advanced Intelligent Systems, EarlyView.
This study introduces a biomarker‐agnostic diagnostic strategy for ovarian cancer, utilizing a machine learning‐enhanced electronic nose to analyze volatile organic compound signatures from blood plasma. By overcoming the dependence on specific biomarkers, this approach enables accurate detection, staging, and cancer type differentiation, offering a ...
Ivan Shtepliuk, Lingyin Meng, Christer Borgfeldt, Jens Eriksson, Donatella Puglisi   +4 more
wiley   +1 more source

Phylogenomics reveals the evolution of floral traits associated with pollinators and pollinator–prey conflict within the carnivorous Pinguicula subgenus Temnoceras

American Journal of Botany, EarlyView.
Abstract Premise The carnivorous plant genus Pinguicula (Lentibulariaceae) exhibits remarkable floral diversity associated with pollination, particularly in the largest subgenus Temnoceras, which spans Mexico and Central America. Despite this diversity, the relationships between species and the evolution of key floral traits remain unresolved. Here, we
Yunjia Liu, Qianshi Lin, Steven J. Fleck, Martín Mata‐Rosas, Enrique Ibarra‐Laclette, Tanya Renner   +5 more
wiley   +1 more source