Results 51 to 60 of about 21,607 (295)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Effect of Lactiplantibacillus plantarum Y279 and Weissella cibaria Y113 inoculation on lipid metabolism and flavor formation in Yu Jiaosuan

Food Chemistry: X
Lipids are key precursors of aroma-active compounds and essential nutrients in Yu Jiaosuan (YJS), a traditional Chinese fermented fish product. This study evaluated the effects of co-inoculating Lactiplantibacillus plantarum Y279 and Weissella cibaria ...
Wenkang Hu, Hongyan Chen, Qin Cen, Shan Yu, Fuyi Hui, Xuefeng Zeng   +5 more
doaj   +1 more source

Correlação entre precursores e voláteis em café arábica brasileiro processado pelas vias seca, semiúmida e úmida e discriminação através da análise por componentes principais

Química Nova, 2012
The influence of pre-processing of arabica coffee beans on the composition of volatile precursors including sugars, chlorogenic acids, phenolics, proteins, aminoacids, trigonelline and fatty acids was assessed and correlated with volatiles formed during ...
Neusa P. Arruda, Ana M. C. Hovell, Claudia M. Rezende, Suely P. Freitas, Sonia Couri, Humberto R. Bizzo   +5 more
doaj   +1 more source

Mechanism of Fruit Ripening - Chapter 16 [PDF]

, 2010
The fruit ripening process has been viewed over the last decades as being successively of physiological, biochemical, and molecular nature. Fruit ripening is accompanied by a number of biochemical events, including changes in color, sugar, acidity ...
Bouzayen, Mondher, Latché, Alain, Nath, Pavendra, Pech, Jean-Claude   +3 more
core   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

Tea aroma formation

Food Science and Human Wellness, 2015
Besides water, tea is one of the most popular beverages around the world. The chemical ingredients and biological activities of tea have been summarized recently.
Chi-Tang Ho, Xin Zheng, Shiming Li
doaj   +1 more source

Aroma enhancement of dealcoholized wines using enzyme treatment and glycosidic aroma precursors

LWT
This research has studied the treatment of dealcoholized wines with glycosidic enzymatic preparation andglycosidic aroma precursors extract isolated from aromatic grapes in order to enhance the aroma profile of nonalcoholicwhite wines. The effect of the addition of the precursors extract and the enzymatic treatment wasstudied after 15 and 30 d of ...
Osorio Alises, Maria, Sánchez Palomo Lorenzo, Eva, González Viñas, Miguel Ángel   +2 more
openaire   +2 more sources

Impact of Sustainable Binders Based on Lignin and Collagen on the Volume Stability and Mechanical Properties of MgO‐C Refractories with MgO‐C Recyclates

Advanced Engineering Materials, EarlyView.
Collagen hydrolysate is evaluated as a sustainable binder for MgO‐C refractories. Its thermally induced cross‐linking and gas release lead to expansion and cracking in large bricks, but tailored batches with lignin, recyclates, or fine graphite improve the gas release while thermal treatment and stability.
Till M. J. Stadtmüller, Florian Kerber, Kirsten Moritz, Steffen Dudczig, Konstantin Kraushaar, Thomas Schemmel, Jana Hubálková, Patrick Gehre, Christos G. Aneziris   +8 more
wiley   +1 more source