Results 81 to 90 of about 438,768 (166)

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

The low density lipoprotein receptor modulates the effects of hypogonadism on diet-induced obesity and related metabolic perturbations

Journal of Lipid Research, 2014
Here, we investigated how LDL receptor deficiency (Ldlr−/−) modulates the effects of testosterone on obesity and related metabolic dysfunctions. Though sham-operated Ldlr−/− mice fed Western-type diet for 12 weeks became obese and showed disturbed plasma
Caterina Constantinou, Diogenis Mpatsoulis, Anastasios Natsos, Peristera-Ioanna Petropoulou, Evangelia Zvintzou, Abdulmaged M. Traish, Peter J. Voshol, Iordanes Karagiannides, Kyriakos E. Kypreos   +8 more
doaj   +1 more source

Assessment of Oxidative Stress, Vitellogenin, and Human Health Risks Derived From Nile Tilapia Exposed to Metals and Metalloids in Southeastern Brazil

Environmental Toxicology, EarlyView.
ABSTRACT Urban coastal lagoons are highly vulnerable ecosystems increasingly affected by metal contamination, as well as multiple anthropogenic stressors. This study evaluated ecotoxicological and human health risks associated with chronic metal exposure in Nile tilapia (Oreochromis niloticus) from an anthropogenically impacted lagoon in southeastern ...
Julia Araújo Alves, Priscila M. O. Muniz Cunha, Shênia Patrícia Corrêa Novo, Lorena Oliveira Souza Soares, Tatiana Dillenburg Saint‐Pierre, Fábio Veríssimo Correia, André Luís de Sá Salomão, Rachel Ann Hauser‐Davis, Enrico Mendes Saggioro   +8 more
wiley   +1 more source

Effect of estrogens on sex-specific influence in sleep deprivation in mice

Brain Research Bulletin
Men and women generally exhibit different sleep patterns and structures. These differences also extend to how each sex responds to sleep deprivation, a condition linked to various health issues.
Qi Deng, Yuhong Li, Zuoli Sun, Xue Fenqin, Xiang Gao, Rena Li   +5 more
doaj   +1 more source

Hypothalamic pituitary gonadal axis (HPG-A) in two men with aromatase deficiency: evidence of estrogen need for the integrity of negative feedback at hypothalamic level

, 2006
Estrogen administration to aromatase deficient men discloses a feedback modulation both at pituitary and hypothalamic ...
ZIRILLI, Lucia, Paula Antunez, Antonio R. M. Granata, DIAZZI, Chiara, ROCHIRA, Vincenzo, Antonio Balestrieri, Claudio Aranda, Laura Maffei, CARANI, Cesare, Bibiana Fabre   +9 more
core  

EE2 and the Fish Brain: Age‐Dependent Impact of 17α‐Ethinylestradiol on Brain Cell Proliferation and Behavior in Sea Bass Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Endocrine‐disrupting chemicals (EDCs), such as 17α‐ethinylestradiol (EE2), have raised concerns about their potential effects on aquatic organisms, particularly during early developmental stages. In this context, the study of behavioral disruption has gained considerable attention, as it may have consequences on individual fitness and ...
Soloperto Sofia, Stephanie Olivier, Céline Thomasse, Christophe Minier, Marie‐Pierre Halm‐Lemeille, Christelle Jozet‐Alves, Salima Aroua   +6 more
wiley   +1 more source

Male production in green sea turtles under a feminizing climate: A validated model of sex ratios with temperature‐dependent sex determination

Journal of Animal Ecology, EarlyView.
This study introduces validated methods to predict sex ratios in wild Green sea turtle (Chelonia mydas) nests. It quantifies beach‐scale temperature heterogeneity, incorporates clutch‐level variation in thermal sensitivity and models temperature effects across the thermosensitive period, demonstrating how temporal temperature dynamics and spatial ...
Marc Girondot, Emily Turla, Kirsty Scott, Jeanette Wyneken   +3 more
wiley   +1 more source

Lack of 17β-estradiol reduces sensitivity to insulin in the liver and muscle of male mice

Heliyon, 2018
The importance of estrogens for glucose homeostasis has been demonstrated by clinical, pharmacological, and experimental studies. Male mice lacking the aromatase gene (ArKO mice), which encodes an enzyme involved in estrogen synthesis, develop glucose ...
Katsumi Toda, Akiko Toda, Masafumi Ono, Toshiji Saibara   +3 more
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Aromatase inhibitors in the treatment of endometriosis [PDF]

, 2016
Endometriosis is a chronic inflammatory condition in which foci of endometrial tissue grow outside of the uterine cavity. Endometriosis was estimated to affect 176 million women of childbearing potential all over the world in 2010.
Błażej Męczekalski, Radosław Słopień   +1 more
core   +1 more source