Results 41 to 50 of about 56,186 (320)
Nature Communications, 2022 Neoadjuvant therapy is recommended for patients with locally advanced breast cancer. Here the authors report the results of a phase 2 clinical trial of oral neoadjuvant therapy with pyrotinib (pan-HER tyrosine kinase inhibitor), letrozole (aromatase ...
Nan Niu +32 more
doaj +1 more source
Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway. [PDF]
, 2014 BackgroundSince PI3K/AKT/mTOR pathway activation diminishes the effects of hormone therapy, combining aromatase inhibitors (anatrozole) with mTOR inhibitors (everolimus) was investigated.Patients and methodsWe evaluated anastrozole and everolimus in 55 ...
Atkins, Johnique T +13 more
core +3 more sources
Arthritis Care &Research, Accepted Article.Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among long‐term HCQ users with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain OCT (SD‐OCT) for screening. Methods A systematic search of PubMed, Scopus,
Narsis Daftarian +4 more
wiley +1 more source
Benzotriazole is antiestrogenic in vitro but not in vivo [PDF]
, 2007 Copyright © 2007 SETAC. This is the accepted version of the following article: Harris et al (2007), "Benzotriazole is antiestrogenic in vitro but not in vivo", Environmental Toxicology and Chemistry, 26(11), 2367–2372, which has been published in final ...
Brian, JV +5 more
core +1 more source
Advanced Science, EarlyView.IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu +9 more
wiley +1 more source
SAGE Open Medicine, 2022 Since their introduction into clinical use in the 1970s, aromatase inhibitors have been a cornerstone of therapy for estrogen-receptor positive breast cancer in postmenopausal women.
Nelly Grigorian, Steven J Baumrucker
doaj +1 more source
Animal Research and One Health, EarlyView.This study delineates the early sex differentiation timeline in the northern snakehead (Channa argus). These findings provide a foundation for future sex‐control breeding in this economically important species. ABSTRACT The northern snakehead (Channa argus) is an economically important aquaculture species in China.
Chaonan Sun +6 more
wiley +1 more source
ICSI cycles in women over 40 years: analysis of 3 different ovarian stimulation protocols
Middle East Fertility Society Journal, 2018 Purpose: To compare the clinical and laboratory outcomes of GnRH agonist stop, aromatase inhibitor/flexible antagonist and ultrashort flare GnRHa/flexible GnRH antagonist protocols in women (40–44) years undergoing ICSI.
H. Sibai, E.A. Elgindy, M.I. Mostafa
doaj +1 more source
Origin of aromatase inhibitory activity via proteochemometric modeling [PDF]
PeerJ, 2016 Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer.
Saw Simeon +7 more
doaj +2 more sources
Skeletal Editing from Pyridine to Aniline via C‐Insertion and N‐Isomerization
ChemistryEurope, EarlyView.A concise protocol is presented that converts pyridines into anilines by externalizing the original pyridine nitrogen at either the "ipso" or "ortho" position, which results in para or meta‐primary aniline products. A key carbene‐insertion step precedes nitrogen migration, preserving both ring size and overall structure.
Yun Luo +3 more
wiley +1 more source