Results 61 to 70 of about 665,294 (217)
Breast Cancer Research, 2020 Background The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer.
Swaathi Jayaraman +21 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley +1 more source
Building families—Implementing balanced sexual and reproductive health
International Journal of Gynecology &Obstetrics, EarlyView.Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu +9 more
wiley +2 more sources
Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses
Frontiers in Molecular Neuroscience, 2018 Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females,
Dusti A. Shay +4 more
doaj +1 more source
Aromatase inhibitor strategies in metastatic breast cancer
, 2009 Heather L McArthur, Patrick G MorrisBreast Cancer Medicine Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Despite ongoing therapeutic innovations, metastatic breast cancer (MBC) remains a treatable but
Patrick G Morris, Heather L McArthur
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Clinical Pharmacology &Therapeutics, EarlyView.Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai +12 more
wiley +1 more source
Treatment Modalities for Aromatase Inhibitor-Associated Musculoskeletal Syndrome (AIMSS): A Scoping Review of Prospective Treatment Studies [PDF]
Justin Andrew Bobo,1 Barbara Lubrano,2 Raul Rosario-Concepcion,3 Alejandra Cuartas-Abril,2 Pooja Advani,4 Saranya Chumsri,4,5 Barbara K Bruce2 1Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; 2Department
Bobo JA +6 more
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Clinical Pharmacology &Therapeutics, EarlyView.Abemaciclib increases serum creatinine by inhibiting renal tubular transporters rather than reducing true glomerular filtration rate, a phenomenon known as pseudo‐acute kidney injury. Creatinine–cystatin C discrepancy and genetic determinants of this elevation remain insufficiently characterized in Japanese patients.
Hiroaki Watanabe +5 more
wiley +1 more source
Steroid Sulfatase Inhibition: From Concept to Clinic and Beyond
Proceedings, 2019 Many tumours are hormone-dependent, and estrogens (E1/E2) play a key role in development.Despite aromatase inhibitor (AI) therapy [...]
Barry V L Potter
doaj +1 more source
Sexuality in a man with aromatase deficiency
, 1998 The evaluation of sexual behavior in a man with aromatase deficiency explains the role of estrogen on male sexuality.
Antonio R. M. Granata +4 more
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