Results 61 to 70 of about 30,153 (204)
Journal of Medical Case Reports, 2017 Background Chemotherapy is considered the most appropriate treatment for metastatic uterine sarcoma, despite its limited efficacy. No other treatment has been conclusively proved to be a real alternative, but some reports suggest that anti-hormonal ...
P. Martin-Romano +7 more
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Aromatase inhibitors and xenograft studies [PDF]
Steroids, 2011 Aromatase inhibitors (AIs) have become the front-line choice for treatment of ER+ breast cancer. Nevertheless, although patients are responsive initially, they may acquire resistance and become unresponsive to further treatment. In addition, approximately 25% of breast cancers do not express the estrogen receptor (ERα) and consequently, are innately ...
Saranya, Chumsri +3 more
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Czech Journal of Animal Science, 2009 The objective of the present work was to study the effect of a nonsteroidal aromatase inhibitor (fadrozole) on proliferation, estradiol production, aromatase expression and telomerase activity (TA) in pig granulosa cells (GC) from small (1-2 mm) and ...
E. Chronowska, M. Tománek, T. Kott
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Breast Cancer Research, 2020 Background The tamoxifen metabolite, Z-endoxifen, demonstrated promising antitumor activity in endocrine-resistant estrogen receptor-positive (ER+) breast cancer.
Swaathi Jayaraman +21 more
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Aromatase inhibitors for the treatment of endometriosis [PDF]
Fertility and Sterility, 2012 To review the use of aromatase inhibitors (AIs) for the treatment of endometriosis.Literature review.Most studies show that in reproductive-age women, the combination of AI with conventional therapy alleviates endometriosis-related pain. In postmenopausal women, using an AI alone has been shown to be an effective treatment, although more studies are ...
Mary Ellen, Pavone, Serdar E, Bulun
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Journal of Comorbidity, 2018 Background The development of comorbidities has become increasingly relevant with longer-term cancer survival. Objective To assess the pattern of comorbidities among Australian women with breast cancer treated with tamoxifen or an aromatase inhibitor ...
Huah Shin Ng +4 more
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Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses
Frontiers in Molecular Neuroscience, 2018 Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals, aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is traditionally associated with reproduction and sexual behavior in females,
Dusti A. Shay +4 more
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Natural Products as Aromatase Inhibitors [PDF]
Anti-Cancer Agents in Medicinal Chemistry, 2008 With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always ...
Marcy J, Balunas +3 more
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Aromatase inhibitor strategies in metastatic breast cancer
, 2009 Heather L McArthur, Patrick G MorrisBreast Cancer Medicine Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Despite ongoing therapeutic innovations, metastatic breast cancer (MBC) remains a treatable but
Patrick G Morris, Heather L McArthur
core
, 2000 A series of experiments was carried out in which genetically female Nile tilapia (Oreochromis niloticus) fry were treated with Fadrozole, a nonsteroidal aromatase inhibitor (AI), in the diet during the period of sexual differentiation. Batches of tilapia
Haghpanah, Vahid +4 more
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