Results 41 to 50 of about 665,294 (217)

Aromatase inhibitor–associated musculoskeletal pain: An overview of pathophysiology and treatment modalities

SAGE Open Medicine, 2022
Since their introduction into clinical use in the 1970s, aromatase inhibitors have been a cornerstone of therapy for estrogen-receptor positive breast cancer in postmenopausal women.
Nelly Grigorian, Steven J Baumrucker
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Origin of aromatase inhibitory activity via proteochemometric modeling [PDF]

PeerJ, 2016
Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer.
Saw Simeon, Ola Spjuth, Maris Lapins, Sunanta Nabu, Nuttapat Anuwongcharoen, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat   +7 more
doaj   +2 more sources

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Study of Aromatase-Catalyzed Metabolic Switching of 2,2-Dimethylandrostenedione : Synthesis of Possible Metabolites and Their Inhibitory Activities of Aromatase [PDF]

, 2004
Aromatase is a cytochrome P-450 enzyme responsible for the conversion of androgens to estrogens. 2,2-Dimethylandrostenedione (5) is one of the powerful inhibitors of the enzyme.
山田, 恵子, 伴田, 和香子, 長岡, 正男, Hannda, Wakako, ヤマダ, ケイコ, Nagaoka, Masao, ヌマザワ, ミツテル, Numazawa, Mituteru, ナガオカ, マサオ, 沼澤, 光輝, ハンダ, ワカコ, Yamada, Keiko   +11 more
core  

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Structures of ACE inhibitor Enalapril, MR antagonists Spironolactone and Eplerenone, CYP11B2 inhibitor Fadrozole and aromatase inhibitor Exemestane.

, 2012
Structures of ACE inhibitor Enalapril, MR antagonists Spironolactone and Eplerenone, CYP11B2 inhibitor Fadrozole and aromatase inhibitor Exemestane.
Qingzhong Hu (124547), Rolf W. Hartmann (124550), Lina Yin (124546)   +2 more
core   +1 more source

Effect of letrozole on spermogram parameters and hormonal profile in infertile men: A clinical trial study

Endocrine Regulations, 2019
Objective. There is no reliable treatment for men with idiopathic infertility, but the relationship between severe sperm production and the ratio of estrogen to testosterone levels has been shown.
Peivandi Sepideh, Jafarpour Hamed, Abbaspour Mina, Ebadi Aghdas   +3 more
doaj   +1 more source

Real-World Treatment Patterns and Clinical Effectiveness of Palbociclib Plus an Aromatase Inhibitor as First-Line Therapy in Advanced/Metastatic Breast Cancer: Analysis from the US Syapse Learning Health Network

Current Oncology, 2022
This retrospective single-arm study assessed real-world treatment patterns and clinical outcomes in patients with hormone receptor—positive/human epidermal growth factor receptor 2—negative (HR+/HER2−) advanced/metastatic breast cancer (A/MBC) who ...
Jeanna Wallenta Law, Debanjali Mitra, Henry G. Kaplan, Tamuno Alfred, Adam M. Brufsky, Birol Emir, Haley McCracken, Xianchen Liu, Ronda G. Broome, Chenan Zhang, Caroline DiCristo, Connie Chen   +11 more
doaj   +1 more source

Aromatase Inhibitor-Induced Carpal Tunnel Syndrome Immunohistochemical Analysis and Clinical Evaluation: An Observational, Cross-Sectional, Case-Control Study. [PDF]

J Clin Med
Background/Objectives: Breast cancer was the leading cause of malignant tumors among women in 2022. About two-thirds of breast cancer cases are hormone-receptor-positive. In these patients, aromatase inhibitors are a mainstay of treatment, but associated
Molayem I, Marcovici LL, Gradini R, Mancini M, Taccogna S, Pagnotta A.   +5 more
europepmc   +2 more sources