Results 21 to 30 of about 30,153 (204)

Aromatase, aromatase inhibitors, and breast cancer [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 2011
Estrogens are known to be important in the growth of breast cancers in both pre and postmenopausal women. As the number of breast cancer patients increases with age, the majority of breast cancer patients are postmenopausal women. Although estrogens are no longer made in the ovaries after menopause, peripheral tissues produce sufficient concentrations ...
Saranya, Chumsri, Timothy, Howes, Ting, Bao, Gauri, Sabnis, Angela, Brodie   +4 more
openaire   +2 more sources

A REGENERATIVE APPROACH TO AN ACUTE EXACERBATION OF HIP PAIN FROM AROMATASE INHIBITOR ASSOCIATED MUSCULOSKELETAL SYNDROME AND AROMATASE-INHIBITOR ARTHRALGIAS

Journal of Cancer Rehabilitation, 2022
Background Despite aromatase inhibitors (AIs) promising outcomes in breast cancer treatment, aromatase inhibitor-associated musculoskeletal syndromes (AIMSS) and aromatase inhibitor arthralgias (AIAs) are common side effects, due to the hypoestrogenic ...
Christian Vangeison, Colton Reeh, Daniel Briggi, Royce Copeland, George Polson, Emanuel N. Husu   +5 more
doaj   +1 more source

Preparation of a novel antiserum to aromatase with high affinity and specificity: Its clinicopathological significance on breast cancer tissue. [PDF]

PLoS ONE, 2017
Aromatase inhibitors have been widely used for the endocrine treatment of estrogen-dependent breast cancer in postmenopausal patients. However, clinicopathological studies of aromatase have been limited due to unsatisfactory specificity and/or restricted
Naoki Kanomata, Shiro Matsuura, Tsunehisa Nomura, Junichi Kurebayashi, Taisuke Mori, Jo Kitawaki, Takuya Moriya   +6 more
doaj   +1 more source

Shear wave elastography detects novel imaging biomarkers of aromatase inhibitor–induced joint pain: a pilot study

Journal of Ultrasonography, 2021
Aim: To determine whether differences in joint and tendon stiffness as measured by ultrasound shear wave elastography are present in breast cancer patients with aromatase inhibitor-associated arthralgias compared to age-comparable healthy control women ...
Martinez Jessica A., Taljanovic Mihra S., Witte Russell S., Nuncio Zuniga Andres A., Wertheim Betsy C., Kwoh C. Kent, Goldstein Brian A., Roe Denise J., Chalasani Pavani   +8 more
doaj   +1 more source

Aromatase expression increases the survival and malignancy of estrogen receptor positive breast cancer cells. [PDF]

PLoS ONE, 2015
In postmenopausal women, local estrogen produced by adipose stromal cells in the breast is believed to support estrogen receptor alpha (ERα) positive breast cancer cell survival and growth.
Keya De Mukhopadhyay, Zhao Liu, Abhik Bandyopadhyay, Nameer B Kirma, Rajeshwar R Tekmal, Shui Wang, Lu-Zhe Sun   +6 more
doaj   +1 more source

A case series of triplet anti-hormonal therapy in androgen receptor-positive recurrent adult ovarian granulosa cell tumor

Gynecologic Oncology Reports, 2022
Therapeutic options for recurrent adult granulosa cell tumors (AGCT) are limited. After examining the hormonal pathways involved in FOXL2-mutated granulosa cell tumor development, a novel treatment regimen was utilized for recurrent AGCT: a combination ...
Rebekah M. Summey, Janet S. Rader, Michelle Moh, William Bradley, Denise Uyar, Erin Bishop, Lindsey McAlarnen, Elizabeth Hopp   +7 more
doaj   +1 more source

Prevalence and correlates of joint pain among Chinese breast cancer survivors receiving aromatase inhibitor treatment [PDF]

, 2022
BACKGROUND: Aromatase inhibitor (AI)-induced joint pain is a common toxicity of AI treatment. Although many studies have been conducted to examine the occurrence and severity of AI-induced joint pain in breast cancer survivors, none of the studies ...
Huang, Hou-Qiang, Molasiotis, A., Tan, Jing-Yu (Benjamin), Wang, T., Yao, Li Qun, Yao, L.-Q., Huang, Yu Yan, Huang, H.-Q., Zheng, Si Lin, Wang, Tao, Liu, Xian-Liang, Liu, X.-L., Tan, Jing Yu, Molassiotis, Alex, Huang, Y.-Y., Tan, J.-Y., Huang, Hou Qiang, Zheng, Si-Lin, Zheng, S.-L., Huang, Yu-Yan, Yao, Li-Qun   +20 more
core   +1 more source

Anastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events

Dermatology and Therapy, 2020
Anastrozole is an aromatase inhibitor. Anastrozole competitively inhibits the aromatase enzyme, which synthesizes estrogen. It is used for estrogen receptor-positive breast cancers.
Yoo Jung Kim, Philip R. Cohen
doaj   +1 more source

Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme

Molecules, 2023
CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resistance
Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. Madhunapantula, Yogish Kumar Honnavalli   +6 more
doaj   +1 more source

Epitope characterization of an aromatase monoclonal antibody suitable for the assessment of intratumoral aromatase activity. [PDF]

PLoS ONE, 2009
Immunohistochemistry is one of the most suitable methods for the detection of intratumoral aromatase in order to identify patients who may respond to aromatase inhibitor therapy in hormone-dependent breast cancer.
Yanyan Hong, Hongzhi Li, Jingjing Ye, Yasuhiro Miki, Yate-Ching Yuan, Hironobu Sasano, Dean B Evans, Shiuan Chen   +7 more
doaj   +1 more source