Results 51 to 60 of about 30,153 (204)

Structures of ACE inhibitor Enalapril, MR antagonists Spironolactone and Eplerenone, CYP11B2 inhibitor Fadrozole and aromatase inhibitor Exemestane.

, 2012
Structures of ACE inhibitor Enalapril, MR antagonists Spironolactone and Eplerenone, CYP11B2 inhibitor Fadrozole and aromatase inhibitor Exemestane.
Qingzhong Hu (124547), Rolf W. Hartmann (124550), Lina Yin (124546)   +2 more
core   +1 more source

Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

Nature Communications, 2016
Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor ...
Pascal Gellert, Corrinne V. Segal, Qiong Gao, Elena López-Knowles, Lesley-Ann Martin, Andrew Dodson, Tiandao Li, Christopher A. Miller, Charles Lu, Elaine R. Mardis, Alexa Gillman, James Morden, Manuela Graf, Kally Sidhu, Abigail Evans, Michael Shere, Christopher Holcombe, Stuart A. McIntosh, Nigel Bundred, Anthony Skene, William Maxwell, John Robertson, Judith M. Bliss, Ian Smith, Mitch Dowsett, POETIC Trial Management Group and Trialists   +25 more
doaj   +1 more source

Inhibition of cytochrome p450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata)

, 2006
In mammalian and avian vertebrate groups, androgens act as controlling agents on male aggression and courtship behaviour by their conversion to oestrogens by cytochrome P450 aromatase in well-defined brain regions.
Olsén, Håkan,, Hallgren, Stefan,, Olsén, K Håkan,, Linderoth, Maria, Linderoth, Maria,, Hallgren, Stefan L E,   +5 more
core   +1 more source

Metabolic effects of aromatase inhibition [PDF]

, 2015
Aromatase, a member of the cytochrome P450 superfamily, catalyses the conversion of androgens to estrogens; specifically, testosterone to estradiol and androstenedione to estrone. Aromatase is widely expressed across a range of tissues and deleterious
Gibb, Fraser Wilson
core  

Effect of letrozole on spermogram parameters and hormonal profile in infertile men: A clinical trial study

Endocrine Regulations, 2019
Objective. There is no reliable treatment for men with idiopathic infertility, but the relationship between severe sperm production and the ratio of estrogen to testosterone levels has been shown.
Peivandi Sepideh, Jafarpour Hamed, Abbaspour Mina, Ebadi Aghdas   +3 more
doaj   +1 more source

Review: Effectively nursing patients receiving aromatase inhibitor therapy

, 2008
Inhibiting estrogen production is a common means of preventing breast cancer recurrence. The aromatase inhibitors (AIs) are becoming the preferred treatment over tamoxifen as adjuvant therapy for postmenopausal women with hormone-sensitive early breast ...
Wengström, Yvonne,, Wengstrom, Yvonne, Wengstrom, Y   +2 more
core   +1 more source

Table_1_Construction and validation of a risk prediction model for aromatase inhibitor-associated bone loss.docx

, 2023
PurposeTo establish a high-risk prediction model for aromatase inhibitor-associated bone loss (AIBL) in patients with hormone receptor-positive breast cancer.MethodsThe study included breast cancer patients who received aromatase inhibitor (AI) treatment.
Yue Zhou (71752), Meiling Chu (250816), Yulian Yin (15364348), Hongfeng Chen (713780), Binjun He (15364351), Meina Ye (787067), Tian Meng (589922), Jingjing Wu (153040), Lan Jin (464006)   +8 more
core   +1 more source

Tissue steroid levels in response to reduced testicular estrogen synthesis in the male pig, Sus scrofa.

PLoS ONE, 2019
Production of steroid hormones is complex and dependent upon steroidogenic enzymes, cofactors, receptors, and transporters expressed within a tissue.
Heidi Kucera, Birgit Puschner, Alan Conley, Trish Berger   +3 more
doaj   +1 more source

Sex Reversal of Red Tilapia (Oreochromis sp.) by Larval Immersion using Aromatase Inhibitor

, 2007
This study was performed to verify the effect of red Nile tilapia (Oreochromis sp.) larval immersion using aromatase inhibitor (1,3-Diaza-2,4-Cyclopentadience) on percentage of male fish.
M. Agus Sudrajat, Sudrajat, M. Agus, Astutik, I.D., Arfah, H., H. Arfah, I.D. Astutik   +5 more
core   +1 more source

Effect of denosumab on bone mineral density in Japanese women with osteopenia treated with aromatase inhibitors for breast cancer: subgroup analyses of a Phase II study

Therapeutics and Clinical Risk Management, 2018
Katsuhiko Nakatsukasa,1 Hiroshi Koyama,2 Yoshimi Ouchi,1 Kouichi Sakaguchi,1 Yoshifumi Fujita,1 Takayuki Matsuda,3 Makoto Kato,4 Eiichi Konishi,5 Tetsuya Taguchi1 1Department of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine ...
Nakatsukasa K, Koyama H, Ouchi Y, Sakaguchi K, Fujita Y, Matsuda T, Kato M, Konishi E, Taguchi T   +8 more
doaj