Results 71 to 80 of about 30,153 (204)

Steroid Sulfatase Inhibition: From Concept to Clinic and Beyond

Proceedings, 2019
Many tumours are hormone-dependent, and estrogens (E1/E2) play a key role in development.Despite aromatase inhibitor (AI) therapy [...]
Barry V L Potter
doaj   +1 more source

Association of Fat Body Mass With Vertebral Fractures in Postmenopausal Women With Early Breast Cancer Undergoing Adjuvant Aromatase Inhibitor Therapy

, 2019
Importance: Aromatase inhibitors induce a profound depletion in serum estrogen levels. Postmenopausal obese women receiving aromatase inhibitor therapy may be at increased risk of bone fractures owing to the detrimental association of adiposity with bone
Rodella F., Pedersini R., Maffezzoni F., Monteverdi S., Simoncini E. L., Maroldi R., TURLA, ANTONELLA, Ardine M., Giustina A., Ravanelli M., Gallo F., Berruti A., Dalla Volta A., Vassalli L., Formenti A. M., Amoroso V.   +15 more
core   +1 more source

Formestane, a steroidal aromatase inhibitor after failure of non-steroidal aromatase inhibitors (anastrozole and letrozole): is a clinical benefit still achievable?

, 2001
There are few clinical data on the sequential use of aromatase inhibitors (AI). This paper focuses on the relevance of clinical benefit CB (CR + PR + SD > or = 6 months) in postmenopausal metastatic breast cancer (MBC) patients treated with the steroidal
Cognetti, F., Casali, A, Fabi, A, Ruggeri, E. M, Papaldo, P, Nardi, M, Carlini, P, De Marco, S, Paoloni, F, FRASSOLDATI, Antonio   +9 more
core   +1 more source

Brain Aromatase in the guppy, Poecilia reticulata [Elektronisk resurs] : Distribution, control and role in behaviour

, 2009
Oestrogens are produced by aromatisation of androgens by the aromatase enzyme. In the vertebrate brain this synthesis has vital functions in nerve protection, cell proliferation and nerve development during injury respectively brain development.
Olsén, Håkan,, Borg, Bertil,, Hallgren, Stefan,, Bakker, Julie,   +3 more
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PENGARUH RANGSANGAN HORMON AROMATASE INHIBITOR DAN OODEV TERHADAP PERUBAHAN KELAMIN DAN PERKEMBANGAN GONAD IKAN KERAPU SUNU, Plectropomus leopardus

, 2018
Permasalahan utama yang dihadapi dalam penyediaan calon induk ikan kerapu sunu Plectropomus leopardus hasil budidaya yang bersifat hermaprodit sekuensial adalah keterlambatan dalam perkembangan gonad dan perubahan gonad dari betina menjadi jantan ...
Yudha, Hirmawan Tirta, Agus Oman Sudrajat, Hirmawan Tirta Yudha, Haryanti, Haryanti, Sudrajat, Agus Oman, Haryanti Haryanti   +5 more
core   +1 more source

Novel inhibitor discovery against aromatase through virtual screening and molecular dynamic simulation [PDF]

, 2013
Inhibition of aromatase (CYTP450) as a key enzyme in the estrogen biosynthesis could result in regression of estrogen-dependent tumors and even preventing the promotion of breast cancer.
Jamalan, Mostafa, Asadabadi, Ebrahim Barzegari, Mirzaie, Sako, Shahverdi, Ahmad Reza, Chupani, Latifeh   +4 more
core   +1 more source

Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats

Reproductive Biology and Endocrinology
Gonadal steroids are involved in the organization and programming of several neural systems. The main objective of this study was to determine whether androgen activity in the early postnatal stage influenced the long-term expression of androgen and ...
Rocío García-Úbeda, Jose Manuel Fernandez-Garcia, Ulises Primo, Daniela Grassi, Antonio Ballesta, Maria Angeles Arevalo, Paloma Collado, Helena Pinos, Beatriz Carrillo   +8 more
doaj   +1 more source

Comparison of uterine peristalsis in artificial hormone treatment versus aromatase inhibitor-stimulated frozen embryo transfer cycles

Gynecological Endocrinology
Objective Uterine peristalsis, which originates from sub-endometrial zone of myometrium, is observed at ultrasonography as a wave-like activity of endometrium.
Erhan Şimşek, Gülşen Doğan Durdağ, Didem Alkaş Yağınç, Selçuk Yetkinel, Pınar Çağlar Aytaç   +4 more
doaj   +1 more source

Effectiveness of bisphosphonate combined with activated vitamin D in patients with aromatase inhibitor-induced osteoporosis after breast cancer operation

Osteoporosis and Sarcopenia, 2018
Objectives: We compared the effectiveness of bisphosphonates combined with activated vitamin D administered for therapy of aromatase inhibitor-induced osteoporosis after a breast cancer operation and primary postmenopausal osteoporosis through propensity
Mizue Tanaka, Soichiro Itoh, Yasuhiro Takeuchi   +2 more
doaj   +1 more source

Seks Reversal Ikan Nila Merah (Oreochromis Sp.) Melalui Perendaman Larva Menggunakan Aromatase Inhibitor [PDF]

, 2007
This study was performed to verify the effect of red Nile tilapia (Oreochromis sp.) larval immersion using aromatase inhibitor (1,3-Diaza-2,4-Cyclopentadience) on percentage of male fish.
H. Arfah, I. D. Astutik, Sudrajat, Agus O   +2 more
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