Results 101 to 110 of about 24,311 (208)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells‐Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Chiara Gnutti, Giulia Sbrini, Carolina Gaudenzi, Valentina Salvi, Daniela Bosisio, Isabella Russo, Silvia Bolognin, Jens C. Schwamborn, Cristina Missale, Chiara Fiorentini   +13 more
wiley   +1 more source

Molecular mechanism of β-arrestin 2 interaction with phosphorylated intracellular loop 3 of dopamine receptor D2

Communications Biology
G protein-coupled receptors (GPCRs), the key regulators of cellular signaling, transduce signals through G proteins or arrestins. G protein- or arrestin-mediated signal transduction induces distinct functional consequences, and therefore the molecular ...
Kiae Kim, Jeong Seok Ji, Hee Ryung Kim, Yoonjung Choi, Hyung Ho Lee, Asuka Inoue, Ka Young Chung   +6 more
doaj   +1 more source

Editorial: G Protein-Coupled Receptor Kinases (GRKs) and β-Arrestins: New Insights Into Disease Regulators

Frontiers in Pharmacology, 2020
Yuichi Hattori, Martin C. Michel
doaj   +1 more source

Arrestin-g pain [PDF]

Nature Chemical Biology, 2019
openaire   +2 more sources

Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation. [PDF]

J Am Chem Soc
Kim TW, Gerrard EJ, Shin J, Gardella TJ, Wootten D, Sexton PM, Cary BP, Gellman SH.   +7 more
europepmc   +1 more source

Editorial: Atypical Functions of Leukocyte Chemoattractant Receptors

Frontiers in Immunology, 2020
José Luis Rodríguez-Fernández, Mario Mellado, Marcus Thelen, Philip M. Murphy   +3 more
doaj   +1 more source

Dynamic Pathway Selectivity of TAS2R5 toward or Away from β-Arrestin or G Protein from Biased Agonists. [PDF]

Biochemistry
Kim D, Strzelinski HR, Longabardi CM, Liggett SB.   +3 more
europepmc   +1 more source

Intrinsic conformational equilibria position arrestin-2 for activation. [PDF]

Protein Sci
Shriver TJ, Kahraman K, Pan M, Dağ Ç, Tonelli M, Robson SA, Ziarek JJ.   +6 more
europepmc   +1 more source

Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation. [PDF]

Biomol Ther (Seoul)
Huang L, Wang M, Kundu D, Paudel S, Peng L, Xian X, Jang CG, Kim KM.   +7 more
europepmc   +1 more source