Results 101 to 110 of about 31,759 (252)
Peripheral targets for neuropathic pain
British Journal of Pharmacology, EarlyView.Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov +2 more
wiley +1 more source
Melanopsin interacts with β-arrestin 1 and β-arrestin 2 in the murine retina.
, 2014 The melanopsin/β-arrestin interaction demonstrated by PLA in mouse retinal sections. Major nuclear layers of the retina defined by DAPI (GCL, Ganglion cell layer; INL, Inner nuclear layer; PRL, Photoreceptor layer).
Phyllis R. Robinson (204369) +1 more
core +1 more source
, 2022 © 2022 Informa UK Limited, trading as Taylor & Francis Group.Objective: This study aimed to analyze maternal serum β-arrestin-1 and β-arrestin-2 concentrations in pregnant women complicated with gestational diabetes mellitus (GDM) and compare them with ...
Gedik Özköse, Zeynep +4 more
core +1 more source
Structural basis of arrestin-3 activation and signaling
Nature Communications, 2017 While arrestins are mainly associated with GPCR signaling, arrestin-3 can signal independently of receptor interaction. Here the authors present the structure of arrestin-3 bound to inositol hexakisphosphate (IP6) and propose a model for arrestin-3 ...
Qiuyan Chen +13 more
doaj +1 more source
A Brief History of the β-Arrestins [PDF]
, 2019 Arrestins have now been implicated in the actions of virtually every G protein-coupled receptor (GPCR) for which they have been examined. Originally discovered for their role in the turnoff of visual perception, their newly discovered pleotropic functions in the cellular and physiological actions of GPCRs not only illuminate new mechanisms of signal ...
Marc G, Caron, Lawrence S, Barak
openaire +2 more sources
The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment
British Journal of Pharmacology, EarlyView.Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton +6 more
wiley +1 more source
Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function [PDF]
, 2010 The ubiquitously expressed mammalian Na(+)/H(+) exchanger 1 (NHE1) controls cell volume and pH but is also critically involved in complex biological processes like cell adhesion, cell migration, cell proliferation, and mechanosensation.
Alexandre Simonin +3 more
core +1 more source
British Journal of Pharmacology, EarlyView.Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan +13 more
wiley +1 more source
, 2019 Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself inducesfurther cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotessurvival signaling responses in vitro ...
Erhe Gao (316689) +7 more
core +1 more source