Results 91 to 100 of about 31,759 (252)
Structural Determinants of Arrestin Functions [PDF]
, 2013 Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elements, including regular ...
Vsevolod V, Gurevich +1 more
openaire +2 more sources
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source
Stable knockdown of β-arrestin-1 and β-arrestin-2 in human mast cells.
, 2013 HMC-1 cells were stably transduced with scrambled shRNA control lentivirus or different clones of shRNA lentivirus targeted against β-arrestin-1 and β-arrestin -2 (Panels A and B).
Hydar Ali (292814) +4 more
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
Over-expression of β-arrestin 1 and β-arrestin 2 increases the rate of melanopsin deactivation.
, 2014 (A) Fluorescent calcium imaging responses in HEK293 cells transiently transfected with wildtype melanopsin: wildtype HEK293 (solid squares) and stable cell lines over-expressing either β-arrestin 1 (open circles), or β-arrestin 2 (solid triangles ...
Phyllis R. Robinson (204369) +1 more
core +1 more source
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Crosslinking and co-immunoprecipitation of β-arrestin 1 and β-arrestin 2 with melanopsin.
, 2014 β-arrestin 1 and β-arrestin 2 co-precipitate with melanopsin in a light- and phosphorylation-dependent manner. (A) Quantitation of β-arrestin 1 co-precipitation with wildtype (MEL) and phosphonull (PØ) melanopsin samples (top). Binding of β-arrestin 1 to
Phyllis R. Robinson (204369) +1 more
core +1 more source
mBioPathogenic microorganisms use varied cellular processes to adapt to the particular stresses encountered in the infected host. These stresses include rapid alterations in ambient temperature, nutrient availability, and extracellular pH.
Lukas M. du Plooy +5 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux +26 more
wiley +1 more source
Insulin Action under Arrestin [PDF]
, 2009 Insulin signaling is key to the etiology of metabolic syndrome. Recent work (Luan et al., 2009) uncovers a role for β-arrestin, previously known to control GPCR desensitization, in insulin signaling.
James, David E., Stöckli, Jacqueline
core +1 more source