Results 141 to 150 of about 49,677 (283)

Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

Pharmacological Research
G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by ligand binding.
Gemma Navarro, Marc Gómez-Autet, Paula Morales, Joan Biel Rebassa, Claudia Llinas del Torrent, Nadine Jagerovic, Leonardo Pardo, Rafael Franco   +7 more
doaj   +1 more source

Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin Phosphorylation [PDF]

, 2009
Xiufeng Song, Sergey A. Vishnivetskiy, Owen P. Gross, K.A. Emelianoff, Ana Méndez, Jeannie Chen, Eugenia V. Gurevich, Marie E. Burns, Vsevolod V. Gurevich   +8 more
openalex   +1 more source

A phase 1 single and multiple ascending dose study of orforglipron in Japanese participants with type 2 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 205-213, February 2026.
Orforglipron, a novel oral non‐peptide GLP‐1 receptor agonist, was evaluated in a Phase 1, double‐blind, placebo‐controlled, randomized, single and multiple ascending dose study in Japanese participants with type 2 diabetes. The safety and tolerability profile of orforglipron was consistent with those of other GLP‐1 receptor agonists, and ...
Kenji Ohwaki, Chino Nakamura, Risa Nasu, Kazumasa Takenouchi, Tetsuaki Hirase   +4 more
wiley   +1 more source

Visual and Both Non-visual Arrestins in Their “Inactive” Conformation Bind JNK3 and Mdm2 and Relocalize Them from the Nucleus to the Cytoplasm [PDF]

, 2006
Xiufeng Song, Dayanidhi Raman, Eugenia V. Gurevich, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich   +4 more
openalex   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Rsp5-mediated ubiquitination of a functional analog of the Rim8 arrestin facilitates Rim pathway activation in Cryptococcus neoformans

mBio
Pathogenic microorganisms use varied cellular processes to adapt to the particular stresses encountered in the infected host. These stresses include rapid alterations in ambient temperature, nutrient availability, and extracellular pH.
Lukas M. du Plooy, Corinna Probst, Matthew E. Capobianco, Charles Giamberardino, Claudia A. Petrucco, J. Andrew Alspaugh   +5 more
doaj   +1 more source

Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration

Frontiers in Pharmacology
IntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor.
Sarah Warren Gooding, Lindsey Felth, Randi Foxall, Zachary Rosa, Kyle Ireton, Izabella Sall, Joshua Gipoor, Anirudh Gaur, Madeline King, Noah Dirks, Cheryl Allyne Whistler, Jennifer Lynne Whistler, Jennifer Lynne Whistler   +12 more
doaj   +1 more source

A Novel Dominant Mutation in SAG , the Arrestin-1 Gene, Is a Common Cause of Retinitis Pigmentosa in Hispanic Families in the Southwestern United States [PDF]

, 2017
Lori S. Sullivan, Sara J. Bowne, Daniel C. Koboldt, Elizabeth L. Cadena, John R. Heckenlively, Kari Branham, Dianna H. Wheaton, Kaylie Webb-Jones, Robert R. German, Mark E. Pennesi, Paul Yang, David Davis-Boozer, Hope Northrup, Vsevold V. Gurevich, Rui Chen, Mingchu Xu, Yumei Li, David G. Birch, Stephen P. Daiger   +18 more
openalex   +1 more source

Design and discovery of a high affinity, selective and β-arrestin biased 5-HT7 receptor agonist

, 2021
Edem K. Onyameh, Edward Ofori, Barbara A. Bricker, Uma Maheshwar Gonela, Suresh Eyunni, Hye Jin Kang, Chandrashekhar Voshavar, Seth Y. Ablordeppey   +7 more
openalex   +2 more sources

Arrestins [PDF]

, 2015
Vsevolod V. Gurevich, Eugenia V. Gurevich   +1 more
openaire   +1 more source