Results 51 to 60 of about 45,700 (234)

A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: β-arrestin 1 protein levels in depression and treatment

Frontiers in Pharmacology, 2013
A limited number of biomarkers in the central and peripheral systems which are known may be useful for diagnosing major depressive disorders and predicting the effectiveness of antidepressant treatments.
Indira eMENDEZ-DAVID, Zeina eEL-ALI, Rene eHEN, Bruno eFALISSARD, Emmanuelle eCORRUBLE, Alain M GARDIER, Saadia eKERDINE-ROMER, Denis Joseph DAVID   +7 more
doaj   +1 more source

Diversity of Light Sensing Molecules and Their Expression During the Embryogenesis of the Cuttlefish (Sepia officinalis)

Frontiers in Physiology, 2020
Eyes morphologies may differ but those differences are not reflected at the molecular level. Indeed, the ability to perceive light is thought to come from the same conserved gene families: opsins and cryptochromes.
Morgane Bonadè, Atsushi Ogura, Erwan Corre, Yann Bassaglia, Yann Bassaglia, Laure Bonnaud-Ponticelli   +5 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Frontiers in Pharmacology, 2020
The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor are important targets in the treatment of both type 2 diabetes mellitus (T2DM) and obesity.
Suleiman Al-Sabah, Lobna Adi, Moritz Bünemann, Cornelius Krasel   +3 more
doaj   +1 more source

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Ahn, Bakshi, Bari, Brailoiu, Coutts, Daigle, Daigle, Dale, Derkinderen, DeWire, Eszter Boros, Fan, Ferguson, Ferguson, Freund, Gaborik, Graham, Guan, Gyombolai, Gábor Turu, Holliday, Hsieh, Hunyady, Jin, Keren, Kleyer, Kouznetsova, Krupnick, Leterrier, Leterrier, László Hunyady, Marullo, McDonald, McDonald, Nguyen, Oakley, Oakley, Pacher, Paing, Parent, Pál Gyombolai, Rinaldi-Carmona, Roche, Rozenfeld, Rozenfeld, Sanchez, Shenoy, Singh, Szekeres, Tohgo, Toth, Turu, Turu, Turu, Turu, Valjent, Varnai, Vines, Ward, Ward, Wei, Woo, Wu, Zhang, Zhao   +64 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]

, 2001
To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P., Chavkin, Charles, Gurevich, Vsevolod V., Kovoor, Abraham, Lowe, Janet   +4 more
core  

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]

, 2017
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M., Benovic, Jeffrey L., Betz, Robin M., Chung, Ka Young, Dror, Ron O., Du, Yang, Duc, Nguyen Minh, Kobilka, Brian K., Komolov, Konstantin E., Leib, Ryan D., Patra, Dhabaleswar, Rodrigues, João P.G.L.M., Skiniotis, Georgios   +12 more
core   +2 more sources

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

The Clinical Significance of β-arrestin 2 Expression in the Serum of 
Non-small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2011
Background and objective Non-small cell lung cancer (NSCLC) with high morbidity and mortality is the most common types of lung cancer. beta-arrestin 2 is a kind of soluble protein regulating signal transduction mediated by G protein coupling receptor ...
Zhengqing WU, Wenxia TONG, Zihui TAN, Siyu WANG, Peng LIN   +4 more
doaj   +1 more source