Results 51 to 60 of about 49,677 (283)

Ubiquitin Ligase Parkin Promotes Mdm2–Arrestin Interaction but Inhibits Arrestin Ubiquitination [PDF]

Biochemistry, 2011
Numerous mutations in E3 ubiquitin ligase parkin were shown to associate with familial Parkinson's disease. Here we show that parkin binds arrestins, versatile regulators of cell signaling. Arrestin-parkin interaction was demonstrated by coimmunoprecipitation of endogenous proteins from brain tissue and shown to be direct using purified proteins ...
M Rafiuddin, Ahmed, Xuanzhi, Zhan, Xiufeng, Song, Seunghyi, Kook, Vsevolod V, Gurevich, Eugenia V, Gurevich   +5 more
openaire   +2 more sources

Evolution of the shut-off steps of vertebrate phototransduction [PDF]

Open Biology, 2018
Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication.
Trevor D. Lamb, Hardip R. Patel, Aaron Chuah, David M. Hunt   +3 more
doaj   +1 more source

Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy [PDF]

, 2004
BACKGROUND: Autoimmune retinal degeneration may occur in patients who present with sudden or, less commonly, subacute loss of vision of retinal origin, associated with an abnormal ERG, through the action of autoantibodies against retinal proteins.
AH Milam, B Lei, CE Thirkill, DM Jacobson, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Ren, G Tezel, Gaoying Ren, Grazyna Adamus, H Ohguro, H Ohguro, I Maruyama, JB Mizener, JL Keltner, JL Keltner, JL Keltner, JR Heckenlively, MA Murphy, MJ Potter, MR Stanford, MS Savchenko, R Peek, R Peek, Richard G Weleber, SM Whitcup, YH Yoon   +31 more
core   +3 more sources

A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: β-arrestin 1 protein levels in depression and treatment

Frontiers in Pharmacology, 2013
A limited number of biomarkers in the central and peripheral systems which are known may be useful for diagnosing major depressive disorders and predicting the effectiveness of antidepressant treatments.
Indira eMENDEZ-DAVID, Zeina eEL-ALI, Rene eHEN, Bruno eFALISSARD, Emmanuelle eCORRUBLE, Alain M GARDIER, Saadia eKERDINE-ROMER, Denis Joseph DAVID   +7 more
doaj   +1 more source

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

Molecules, 2020
We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation.
Alexander Vogel, Mathias Bosse, Marcel Gauglitz, Sarah Wistuba, Peter Schmidt, Anette Kaiser, Vsevolod V. Gurevich, Annette G. Beck-Sickinger, Peter W. Hildebrand, Daniel Huster   +9 more
doaj   +1 more source

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5. [PDF]

, 2017
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling.
Adams, Christopher M., Benovic, Jeffrey L., Betz, Robin M., Chung, Ka Young, Dror, Ron O., Du, Yang, Duc, Nguyen Minh, Kobilka, Brian K., Komolov, Konstantin E., Leib, Ryan D., Patra, Dhabaleswar, Rodrigues, João P.G.L.M., Skiniotis, Georgios   +12 more
core   +2 more sources

Diversity of Light Sensing Molecules and Their Expression During the Embryogenesis of the Cuttlefish (Sepia officinalis)

Frontiers in Physiology, 2020
Eyes morphologies may differ but those differences are not reflected at the molecular level. Indeed, the ability to perceive light is thought to come from the same conserved gene families: opsins and cryptochromes.
Morgane Bonadè, Atsushi Ogura, Erwan Corre, Yann Bassaglia, Yann Bassaglia, Laure Bonnaud-Ponticelli   +5 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

The Clinical Significance of β-arrestin 2 Expression in the Serum of 
Non-small Cell Lung Cancer Patients

Chinese Journal of Lung Cancer, 2011
Background and objective Non-small cell lung cancer (NSCLC) with high morbidity and mortality is the most common types of lung cancer. beta-arrestin 2 is a kind of soluble protein regulating signal transduction mediated by G protein coupling receptor ...
Zhengqing WU, Wenxia TONG, Zihui TAN, Siyu WANG, Peng LIN   +4 more
doaj   +1 more source

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Frontiers in Pharmacology, 2020
The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor are important targets in the treatment of both type 2 diabetes mellitus (T2DM) and obesity.
Suleiman Al-Sabah, Lobna Adi, Moritz Bünemann, Cornelius Krasel   +3 more
doaj   +1 more source