Results 71 to 80 of about 45,700 (234)

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling [PDF]

, 2018
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro ...
Benovic, Jeffrey L., Carter, Rhonda L., de Lucia, Claudio, Gao, Erhe, Grisanti, Laurel A., Koch, Walter J., Thomas, Toby P., Tilley, Douglas G.   +7 more
core   +1 more source

Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers [PDF]

, 2014
Introduction Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by ...
A Boudot, A Levoye, AE Gururaj, AH Evans, AK Dunbier, Anita Dunbier, Aradhana Rani, AS Coutts, B Györffy, BC Nair, CA Moore, CM Chan, DG Duda, EA Musgrove, F Andre, GJ Sabnis, H Shankar, H Zheng, J Kang, J Xu, JM Burns, K Hattermann, K Sauvé, KE Luker, LA Martin, LA Martin, LA Martin, Lesley-Ann Martin, LV Rhodes, M Dowsett, Mitch Dowsett, MJ Ellis, MR Hara, MT Weigel, N Lapteva, OE Hawkins, Qiong Gao, R Santen, RD Berahovich, Ricardo Ribas, RK Singh, S Ali, S Masamura, S Masri, S Rajagopal, SE Ghayad, SM DeWire, Sunil Pancholi, TJ Frederick, TN Hartmann, V Lakshmikanthan, Y Shi, YC Su, Z Liang, Zara Ghazoui   +54 more
core   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

β-Arrestins and Cell Signaling [PDF]

Annual Review of Physiology, 2007
Upon their discovery, β-arrestins 1 and 2 were named for their capacity to sterically hinder the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately resulting in receptor desensitization. Surprisingly, recent evidence shows that β-arrestins can also function to activate signaling cascades independently of G protein ...
Scott M, DeWire, Seungkirl, Ahn, Robert J, Lefkowitz, Sudha K, Shenoy   +3 more
openaire   +2 more sources

Structural basis of arrestin-3 activation and signaling

Nature Communications, 2017
While arrestins are mainly associated with GPCR signaling, arrestin-3 can signal independently of receptor interaction. Here the authors present the structure of arrestin-3 bound to inositol hexakisphosphate (IP6) and propose a model for arrestin-3 ...
Qiuyan Chen, Nicole A. Perry, Sergey A. Vishnivetskiy, Sandra Berndt, Nathaniel C. Gilbert, Ya Zhuo, Prashant K. Singh, Jonas Tholen, Melanie D. Ohi, Eugenia V. Gurevich, Chad A. Brautigam, Candice S. Klug, Vsevolod V. Gurevich, T. M. Iverson   +13 more
doaj   +1 more source

Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

Nature Communications, 2021
The interaction between a GPCR, such as the vasopressin receptor-2 (V2R), and arrestin depends on the receptors’ phosphorylation pattern. Here authors use FRET and NMR to analyze the phosphorylation patterns of the V2R-arrestin complex and show that ...
Qing-Tao He, Peng Xiao, Shen-Ming Huang, Ying-Li Jia, Zhong-Liang Zhu, Jing-Yu Lin, Fan Yang, Xiao-Na Tao, Ru-Jia Zhao, Feng-Yuan Gao, Xiao-Gang Niu, Kun-Hong Xiao, Jiangyun Wang, Changwen Jin, Jin-Peng Sun, Xiao Yu   +15 more
doaj   +1 more source

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease [PDF]

, 2013
The cAMP signaling system can trigger precise physiological cellular responses that depend on the fidelity of many protein–protein interactions, which act to bring together signaling intermediates at defined locations within cells.
Brunton, Donald H Maurice, Dreiza, George S Baillie, Hayes, Li, Louisa CY Lee, Shenoy, Tavalin   +8 more
core   +1 more source

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source