Results 71 to 80 of about 178,362 (241)

Multidisciplinary corroboration in differentiation syndrome: a case report

Journal of Medical Case Reports, 2021
Background Differentiation syndrome (DS) is a life-threatening complication that may be seen in patients with acute promyelocytic leukaemia undergoing induction therapy with all-trans retinoic acid or arsenic trioxide.
Sayan Sarkar, Priya Ghosh, Anisha Gehani, Niharendu Ghara, Parthasarathi Bhattacharyya   +4 more
doaj   +1 more source

Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide [PDF]

, 2008
Background Arsenic trioxide (As2O3) exhibits promising anticarcinogenic activity in acute promyelocytic leukemic patients and induces apoptosis in various tumor cells in vitro.
Tseng-Hsi Lin, Hsing-Chun Kuo, Fen-Pi Chou, Fung-Jou Lu, EM Rego, ZY Wang, T Bachleitner-Hofmann, WH Miller, JR Berenson, YM Li, Y Akao, AJ Murgo, TD Zhang, AM Bode, Z Chen, HD Halicka, LH Wei, WMW Cheung, RN Ratnaike, WT Couldwell, AB da Rocha, J Hofmann, HJ Mackay, K-K Cho, MM Lahn, W Zhang, K Masur, M Serova, J Koivunen, D Roychowdhury, JS Rao, NE Sounni, JH Uhm, M-J Park, LR Schiller, JM Hwang, KV Anis, CL Kuo, G Yount, PL Peng, S Letašiová, SK Mantena, Y Jing, P Benda, T Mosmann, HC Kuo, HC Kuo, S Pervaiz, C Larsson, TR Sharif, R Assert, AB da Rocha, R Seger, DC Schonwasser, M Auvinen, CW Lau, JM Hwang, AM Bode, X Cai, N Levicar, M Bredel, R Mandil, Z Dong, NY Chen, WY Au   +64 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Thermogravimetric and distillation studies on mercury, antimony and arsenic sulfides [PDF]

, 1975
Thermogravimetric studies were made on naturally occurring sulfides of mercury, antimony and arsenic to determine activation energies and Arrhenius rates of reaction in vacuum and in atmospheres of air and nitrogen. Of the three sulfides only antimony
Rao, P.D., Town, J.W.
core  

Frontline ATRA‐ATO Therapy for Acute Promyelocytic Leukemia in Japan: Results From the Prospective Multicenter FBMTG‐APL2017 Trial

Cancer Science, EarlyView.
FBMTG‐APL2017: First prospective multicenter trial evaluating frontline ATRA‐ATO therapy for newly diagnosed APL in Japan, encompassing both low–intermediate (n = 65) and high‐risk (n = 16) patients. Excellent outcomes (95% CR, 94% 3‐year DFS) with comparable efficacy between risk groups (DFS: 97% vs.
Ken Takase, Tomohiko Kamimura, Takuro Kuriyama, Takahito Tokuyama, Hideho Henzan, Yoshikane Kikushige, Ilseung Choi, Yutaka Imamura, Akio Mori, Shuki Ohya, Noriaki Kawano, Koji Yonemoto, Mine Harada, Koichi Akashi, Toshihiro Miyamoto   +14 more
wiley   +1 more source

FORMULATION OF ORAL COMPOSITIONS COMPRISING ARSENIC TRIOXIDE AND METHODS OF USE THEREOF [PDF]

, 2004
The present invention provides an oral formulation of arsenic trioxide (As2O3) for the treatment of a variety of hematological malignancies, including acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

core  

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity.

Toxicological Sciences, 2019
Arsenic exposure is a worldwide health concern associated with an increased risk of skin, lung, and bladder cancer but arsenic trioxide (AsIII) is also an effective chemotherapeutic agent.
Amin Sobh, A. Loguinov, G. Yazici, Rola S. Zeidan, A. Tagmount, N. Hejazi, A. Hubbard, Luoping Zhang, C. Vulpe   +8 more
semanticscholar   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Combination Effect Of Low Dose of Arsenic Trioxide And AZT On Viability And Metabolic Activity Of NB4 Cell Line [PDF]

پیاورد سلامت, 2011
Background and Aim: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia. APL is characterized by a balanced reciprocal translocation between chromosomes 15 and 17, t(517)).
R Mirzaee Khalilabadi, H Mardani Valandani, D Bashshash, N Einollahi, K Ali Moghaddam, A Ghavamzadeh, SH Ghaffari   +6 more
doaj   +1 more source