Results 61 to 70 of about 13,610 (191)

Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells.

Folia Histochemica et Cytobiologica, 2010
Actin is one of the cytoskeletal proteins that take part in many cellular processes. The aim of this study was to show the influence of Trisenox (arsenic trioxide), on the cytoplasmic and nuclear F-actin organization. Arsenic trioxide is the proapoptotic
Dariusz Grzanka, Agnieszka Zuryń, Maciej Ostrowski, Alina Grzanka, Magdalena Izdebska   +4 more
doaj   +1 more source

Multidisciplinary corroboration in differentiation syndrome: a case report

Journal of Medical Case Reports, 2021
Background Differentiation syndrome (DS) is a life-threatening complication that may be seen in patients with acute promyelocytic leukaemia undergoing induction therapy with all-trans retinoic acid or arsenic trioxide.
Sayan Sarkar, Priya Ghosh, Anisha Gehani, Niharendu Ghara, Parthasarathi Bhattacharyya   +4 more
doaj   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, Volume 159, Issue 2, Page 460-466, 15 July 2026.
What's new? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Primary Extramedullary Acute Promyelocytic Leukemia Presenting as Cauda Equina Syndrome: A Rare Case Report and Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT APL presenting as an extramedullary mass is exceedingly rare. Here, we describe extramedullary APL causing cauda equina syndrome, underscoring the diagnostic challenges associated with an atypical presentation, highlighting the complexity of distinguishing extramedullary APL from other conditions, and discussing the stepwise approach to ...
Amir Ali, Marc Ringor, Arbab Khalid, Diana Garcia, Ravishankar Konchada, Ramalingam Ratnasabapathy, Yuna Chae, Arman Melikyan, George Yaghmour   +8 more
wiley   +1 more source

Microbial oxidation of arsenite in a subarctic environment: diversity of arsenite oxidase genes and identification of a psychrotolerant arsenite oxidiser [PDF]

, 2010
Background Arsenic is toxic to most living cells. The two soluble inorganic forms of arsenic are arsenite (+3) and arsenate (+5), with arsenite the more toxic.
Hudson-Edwards, KA, Osborne Thomas H, Osborne, T.H., Hudson-Edwards, Karen A., Walker, Stephen R., Osborne, Thomas H., Stephen R Walker, Hudson-Edwards Karen A, Joanne M Santini, Santini, JM, Ward, S.A., Jamieson, H.E., Thomas H Osborne, Nordstrom, DK, Nordstrom, K., Nordstrom, D. Kirk, Jamieson, HE, Walker, S.R., Santini, J.M., Ward, Seamus A., Ward Seamus A, Jamieson, Heather E., Osborne, TH, Osborne, Tom, Heather E Jamieson, Jamieson Heather E, Santini, Joanne M., Karen A Hudson-Edwards, Seamus A Ward, Walker Stephen R, Walker, SR, D Kirk Nordstrom, Nordstrom D Kirk, Santini Joanne M, Ward, SA   +34 more
core   +1 more source

Qingdainone, a novel bioactive compound in Realgar‒Indigo naturalis, induced apoptosis and differentiation in ATRA‐sensitive and ‐resistant acute promyelocytic leukaemia cells

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Network pharmacology identified Qingdainone as a key bioactive compound in RIF. 2. Molecular docking revealed strong binding affinities of Qingdainone to targets such as CCND1, CDK1, CDK4, CASP3 and CASP7. 3. Qingdainone interfered proliferation and apoptosis, and promoted differentiation, of ATRA‐sensitive and ‐resistant APL cells, such that ...
Pengcheng Xu, Yang Ou, Xin Tan, Lili Ji, Yanxia Zhan, Pu Chen, Hao Chen, Yunfeng Cheng   +7 more
wiley   +1 more source

Combination Effect Of Low Dose of Arsenic Trioxide And AZT On Viability And Metabolic Activity Of NB4 Cell Line [PDF]

پیاورد سلامت, 2011
Background and Aim: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia. APL is characterized by a balanced reciprocal translocation between chromosomes 15 and 17, t(517)).
R Mirzaee Khalilabadi, H Mardani Valandani, D Bashshash, N Einollahi, K Ali Moghaddam, A Ghavamzadeh, SH Ghaffari   +6 more
doaj   +1 more source

Effects of arsenic trioxide on human hepatoma cells. [PDF]

, 2001
Siu Pak-yan.Thesis (M.Phil.)--Chinese University of Hong Kong, 2001.Includes bibliographical references (leaves 158-174).Abstracts in English and Chinese.Acknowledgement --- p.iAbstract --- p.ii摘要 --- p.ivContents --- p.viList of Figures and Tables --

core  

Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang, Chenyang Mu, Rui Zhao, Runwei Ma, Xuehai Liu, Haoling Zhang, Zengwu Wang, Jing‐jing Zhang   +7 more
wiley   +1 more source

Hematotoxicity of intratracheally instilled arsenic trioxide in rats

, 2018
The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Wistar rats were randomly divided into four study groups that were treated with saline (control) or arsenic ...
Chunyu Yuan, Yajie Liang, Chao Liu, Haiying Wang, Mingxing Su, Congsong Sun, Ruixia Guo, Qiang Wang   +7 more
core   +1 more source