Results 41 to 50 of about 13,610 (191)

Acute Encephalopathy Following Arsenic Trioxide for Metastatic Urothelial Carcinoma

, 2011
There have been no prior reports of central nervous system toxicity following arsenic trioxide in patients with solid tumors. We report three metastatic urothelial carcinoma patients who were treated with arsenic trioxide (0.24 mg/kg/ d 3-hour ...
林家齊;蒲永孝;徐志宏;耿孝宜;鄭安理;楊志新, LIN, CHIA-CHI;PU, YEONG-SHIAU;HSU, CHIH-HUNG;KENG, HSIAO-YI;CHENG, ANN-LII;YANG, CHIH-HSIN   +1 more
core   +1 more source

Arsenic Trioxide Compound Modulates Multiple Myeloma Phenotypes: Assessment on Cell Line Models [PDF]

Iranian Journal of Public Health, 2006
Recent evidences suggest that multiple myeloma phenotypes (MMPs) are involved in the infiltration of multiple myeloma-affected marrow foci. In this study, the effects of arsenic trioxide on the invasive and angiogenic phenotypes of multiple myeloma (MM ...
MR Khorramizadeh, F Saadat, H Allahyary, S Sadeghian, A Sarrafnejad, A Mirshafiey, F Safavifar, K Alimoghaddam, A Ghavamzadeh, M Pezeshki   +9 more
doaj   +2 more sources

Relapsed acute promyelocytic leukemia in a hemodialysis-dependent patient treated with arsenic trioxide: a case report

Journal of Medical Case Reports, 2012
Introduction In the relapsed setting, arsenic trioxide remains the backbone of treatment. Scant literature exists regarding treatment of relapsed acute promyelocytic leukemia in patients with renal failure.
Emmons Gregory S, Steingart Richard H, Stewart James A, Mertens Wilson C   +3 more
doaj   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Arsenic Trioxide Modulates the Central Snail Neuron Action Potential

, 2010
Background/Purpose: The electropharmacological effect of arsenic trioxide (AS(2)O(3)) is unknown. The present study investigated the effects of AS( 2)O(3) on spontaneous neuronal impulse activity.
盧冠伶;張玉琪;陳易宏;蔡明正, LU, GUAN-LING;CHANG, YU-CHI;CHEN, YI- HUNG;TSAI, MING-CHENG   +1 more
core   +1 more source

Reconceptualizing Aplastic Anemia—Seed, Worm, Soil

Journal of Clinical Laboratory Analysis, EarlyView.
Aplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xintong Xu, Zining Wang, Jiaming Hu, Chunyan Liu, Rong Fu   +4 more
wiley   +1 more source

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma [PDF]

, 2014
Background: Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide was poorly effective against ...
Xuan Song, Chen, Xi, Lianxin Liu, Dalong Yin, Jiaren Liu, Li, Yuejin, Zhaoyang Lu, Hongchi Jiang, Yuejin Li, Song, Xuan, Jiabei Wang, Jiang, Hongchi, Yin, Dalong, Sun, Boshi, Tongsen Zheng, Shuyi Qi, Xie, Changming, Lu, Zhaoyang, Pan, Shangha, Liu, Jiaren, Xi Chen, Meng, Xianzhi, Changming Xie, Wang, Jiabei, Boshi Sun, Shangha Pan, Xianzhi Meng, Zheng, Tongsen, Liu, Lianxin, Yingjian Liang, Liang, Yingjian, Qi, Shuyi   +31 more
core   +1 more source

Arsonic Acid Functional Polymers Enable Stabilization of Iron Oxide Nanoparticles in Aqueous Solution

Macromolecular Rapid Communications, EarlyView.
Arsonic acid containing diblock copolymers are developed to incorporate arsonic acid moieties for surface anchoring to IONPs, along with water soluble PEG blocks to impart colloidal stability in aqueous environments. The resulting polymer‐coated IONPs are evaluated for stability in physiological media and cytocompatibility.
Nhu Thao Huynh, Alexander Rajakanthan, Jurie Tashkandi, Rafia Rafique, Milad Ghorbani, Zihnil A. I. Mazrad, Nicole M. Warne, Kiyonori Suzuki, Karen Alt, Paul Wilson, Kristian Kempe   +10 more
wiley   +1 more source

Treatment of new cases of Acute Promyelocytic Leukemia With Arsenic Trioxide [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2005
Introduction: Arsenic Trioxide is effective and approved for treatment of relapsed or refractory APL cases to ATRA but its effects in new cases of APL is not clear and needs long term follow up to dis¬close the role of this drug in treatment of APL in ...
Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Hamidolah Ghafari, Shahrbano Rostami, Yousef Mortazavi, Mohamad Jahani, Roholah Hosseini, Asadolah Mossavi, Massoud Iravani, Babak Bahar, Mehrangiz Totonchi, Ali Khodabandeh, Nasser Aghdami   +12 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source