Results 41 to 50 of about 96,549 (135)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Localised Autophagy Inhibition by Nanodiamonds Potentiates Arsenic Therapy With Favourable Safety Profile in Solid Tumours

Cell Proliferation, EarlyView.
This study presents an NDs‐mediated localised combination strategy that integrates autophagy inhibition with low‐dose ATO sensitization, enabling effective tumour suppression while enhancing safety. NDs‐mediated autophagy blockade enhances ATO efficacy while minimising systemic toxicity, highlighting a promising approach for solid tumour treatment ...
Yiliu Wang, Zhifen Cui, Jichao Zhang, Shitai Zhu, Linjie Guo, Qisheng Wang, Ying Zhu, Shihua Luo, Huating Kong   +8 more
wiley   +1 more source

Evaluation of exposure to arsenic in residential soil. [PDF]

, 2005
In response to concerns regarding arsenic in soil from a pesticide manufacturing plant, we conducted a biomonitoring study on children younger than 7 years of age, the age category of children most exposed to soil.
Eric A. Crecelius, Scrafford, Carolyn G, Barraj, Leila M, Leila M. Barraj, Pamela J. Mink, Michael Goodman, Van Kerkhove, Maria D, Kaetzel, Rhonda S, Maria D. Van Kerkhove, Goodman, Michael, Rhonda S. Kaetzel, Joyce S. Tsuji, Tsuji, Joyce S, Mink, Pamela J, Carolyn G. Scrafford, Crecelius, Eric A   +15 more
core   +1 more source

Feasibility and Safety of Venetoclax for Cytoreduction During Induction Therapy in Newly Diagnosed Acute Promyelocytic Leukemia

European Journal of Haematology, EarlyView.
ABSTRACT Objective This study aimed to evaluate the feasibility and safety of venetoclax as a cytoreductive strategy during induction therapy in newly diagnosed acute promyelocytic leukemia (APL), and to provide an exploratory description of its early efficacy.
Yu Wang, Rong Xiao, Xiaobing Huang, Yi Xiao   +3 more
wiley   +1 more source

Arsenic Trioxide Modulates the Central Snail Neuron Action Potential

, 2010
Background/Purpose: The electropharmacological effect of arsenic trioxide (AS(2)O(3)) is unknown. The present study investigated the effects of AS( 2)O(3) on spontaneous neuronal impulse activity.
盧冠伶;張玉琪;陳易宏;蔡明正, LU, GUAN-LING;CHANG, YU-CHI;CHEN, YI- HUNG;TSAI, MING-CHENG   +1 more
core   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Isolation and Structural Elucidation of the Pnictogen Polysulfate Compounds As2[S2O7]2[S3O10] and [SeCl3][Pn(S2O7)2] (Pn = Sb, Bi)

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 14, 23 September 2026.
The isolation and solid‐state structures of the two disulfate‐containing pnictogenates [SeCl3][Pn(S2O7)2] (Pn = Sb, Bi), as well as the mixed‐anionic As2[S2O7]2[S3O10] are presented. The former two consist of complex ∞1{[Pn(S2O7)1/1t(S2O7)2/2e]‐}$$ {\infty }^{1}\left\{{\left[\mathrm{Pn}{\left({\mathrm{S}}_{2}{\mathrm{O}}_{7}\right)}_{1/1}^{\mathrm{t}}{\
Jan Langwald, Luisa Ebels, Marios Symeonidis, Jörn Bruns, Antonio Frontera, Mathias S. Wickleder   +5 more
wiley   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, Volume 13, Issue 52, 18 September 2026.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Genetic variation in arsenic (+3 oxidation state) methyltransferase (AS3MT), arsenic metabolism and risk of basal cell carcinoma in a European population. [PDF]

, 2014
Exposure to inorganic arsenic increases the risk of basal cell carcinoma (BCC). Arsenic metabolism is a susceptibility factor for arsenic toxicity, and specific haplotypes in arsenic (+3 oxidation state) methyltransferase (AS3MT) have been associated ...
Koppova, K, Vahter, Marie, Broberg Palmgren, Karin, Kumar, Rajiv, Fletcher, T, Engström, Karin S, Broberg, K,, Goessler, W, Engstrom, KS, Koppova, Kvetoslava, Rudnai, Peter, Gurzau, E, Gurzau, Eugen, Goessler, Walter, Leonardi, Giovanni, Leonardi, G, Rudnai, P, Engström, Karin, Vahter, M,, Broberg, Karin, Fletcher, Tony, Kumar, R, Engström, Karin,, Broberg Palmgren, Karin,, Lund University.   +24 more
core   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, Volume 4, Issue 3, September 2026.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source