Results 21 to 30 of about 13,610 (191)

Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. [PDF]

PLoS ONE, 2012
Estrogen receptor α (ERα) is a marker predictive for response of breast cancers to endocrine therapy. About 30% of breast cancers, however, are hormone- independent because of lack of ERα expression. New strategies are needed for re-expression of ERα and
Juan Du, Nannan Zhou, Hongxia Liu, Fei Jiang, Yubang Wang, Chunyan Hu, Hong Qi, Caiyun Zhong, Xinru Wang, Zhong Li   +9 more
doaj   +1 more source

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]

, 2014
Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J., Hay, Ronald T., Everett, R.D., Hay, R.T., Hands, Katherine J., Cuchet-Lourenco, Delphine, Everett, Roger D., Cuchet-Lourenco, D.   +7 more
core   +1 more source

The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells

World Journal of Surgical Oncology, 2010
Background Arsenic trioxide has been established as a first-line agent for treating acute promyelocytic leukemia. Experimental data suggest that arsenic trioxide also can have a potential use as chemotherapeutic agent for other malignancies.
Li Qiu, Ye Aifang, Zhou Mengtao, Zheng Yihu, Bai Yongheng, Zhang Qiyu   +5 more
doaj   +1 more source

Realgar transforming solution as a novel arsenic agent with a lower risk of cardiotoxicity

Journal of Pharmacological Sciences, 2019
QTc prolongation has been observed during arsenic trioxide and realgar's clinical use, and become a huge obstacle for the application. Our lab has obtained the soluble arsenic from realgar named realgar transforming solution or RTS.
Yang Hai, Peng Song, Xin Wang, Longhe Zhao, Qinjian Xie, Jianyin Li, Yang Li, Hongyu Li   +7 more
doaj   +1 more source

Inorganic arsenic trioxide induces gap junction loss in association with the downregulation of connexin43 and E-cadherin in rat hepatic “stem-like” cells

Kaohsiung Journal of Medical Sciences, 2014
Chronic exposure to inorganic arsenic trioxide causes tumors of the skin, urinary bladder, lung, and liver. Several cancer initiators and promoters have been shown to alter cell–cell signaling by interference with gap junction intercellular communication
Pi-Jung Hsiao, Jo-Chi Jao, Jin-Lian Tsai, Wen-Tsan Chang, Kuo-Shyang Jeng, Kung-Kai Kuo   +5 more
doaj   +1 more source

Breast-feeding protects against arsenic exposure in Bangladeshi infants. [PDF]

, 2008
BACKGROUND: Chronic arsenic exposure causes a wide range of health effects, but little is known about critical windows of exposure. Arsenic readily crosses the placenta, but the few available data on postnatal exposure to arsenic via breast milk are not ...
Nermell, Barbro, Britta Fängström, Kuenstl, Linda, Vahter, Marie, Goessler, Walter, Barbro Nermell, Brita Palm, Marie Vahter, Iqbal Kabir, Linda Kuenstl, Palm, Brita, Kabir, Iqbal, Walter Goessler, Fängström, Britta, Arifeen, Shams El, Margaretha Grandér, Shams El Arifeen, Sophie Moore, Grandér, Margaretha, Moore, Sophie   +19 more
core   +1 more source

The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel

BMC Medical Genomics, 2010
Background Drinking water contaminated with inorganic arsenic is associated with increased risk for different types of cancer. Paradoxically, arsenic trioxide can also be used to induce remission in patients with acute promyelocytic leukemia (APL) with a
Liu Qian, Zhang Hao, Smeester Lisa, Zou Fei, Kesic Matt, Jaspers Ilona, Pi Jingbo, Fry Rebecca C   +7 more
doaj   +1 more source

Successful treatment of acute promyelocytic leukemia in a patient undergoing hemodialysis with arsenic trioxide

Clinical Case Reports, 2021
A man undergoing hemodialysis was diagnosed with acute promyelocytic leukemia (APL). He received arsenic trioxide as a single agent and achieved complete molecular remission without severe adverse events.
Akiko Hashimoto, Yasuhiro Tanaka, Isaku Shinzato   +2 more
doaj   +1 more source

An Efficient Synthesis of Novel Dextran-Arsenite Nanoparticles intended for Potential Antitumor Drug Material [PDF]

Anais da Academia Brasileira de Ciências, 2021
The functionalization of polysaccharides with synthetic nanopolymers has attracted great attention owing to the applications of this method in many industrial fields.
WEIBING LAN, SHAN CHEN, GUANGZAI NONG
doaj   +1 more source

Arsenic Primes Human Bone Marrow CD34+ Cells for Erythroid Differentiation

Bioinorganic Chemistry and Applications, 2015
Arsenic trioxide exhibits therapeutic effects on certain blood malignancies, at least partly by modulating cell differentiation. Previous in vitro studies in human hematopoietic progenitor cells have suggested that arsenic may inhibit erythroid ...
Yuanyuan Zhang, Shasha Wang, Chunyan Chen, Xiao Wu, Qunye Zhang, Fan Jiang   +5 more
doaj   +1 more source