Results 21 to 30 of about 30,301 (244)

Arsenic trioxide sensitizes glioblastoma to a myc inhibitor. [PDF]

PLoS ONE, 2015
Glioblastoma multiforme (GBM) is associated with high mortality due to infiltrative growth and recurrence. Median survival of the patients is less than 15 months, increasing requirements for new therapies. We found that both arsenic trioxide and 10058F4,
Yayoi Yoshimura, Akihiko Shiino, Kazue Muraki, Tadateru Fukami, Shigeki Yamada, Takeshi Satow, Miyuki Fukuda, Masaaki Saiki, Masato Hojo, Susumu Miyamoto, Nobuyuki Onishi, Hideyuki Saya, Toshiro Inubushi, Kazuhiko Nozaki, Kenji Tanigaki   +14 more
doaj   +1 more source

The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells

World Journal of Surgical Oncology, 2010
Background Arsenic trioxide has been established as a first-line agent for treating acute promyelocytic leukemia. Experimental data suggest that arsenic trioxide also can have a potential use as chemotherapeutic agent for other malignancies.
Li Qiu, Ye Aifang, Zhou Mengtao, Zheng Yihu, Bai Yongheng, Zhang Qiyu   +5 more
doaj   +1 more source

Arsenic Trioxide: Pharmacological Applications

Vitae, 2023
Background: Arsenic trioxide is a chemical compound that has been used as a treatment for various diseases. Despite being potentially toxic, this compound has been used as a therapy to treat Acute Myeloid Leukemia and is being investigated as a possible ...
German Madrigal Redondo, María Fernanda Rojas Salas, Rolando Vargas Zúñiga, Daniela González Corrales, Celeste Ortega Monge, Pamela Ceciliano Porras, Mariana Cerdas Delgado, Jeison Montero Rivera   +7 more
doaj   +1 more source

Realgar transforming solution as a novel arsenic agent with a lower risk of cardiotoxicity

Journal of Pharmacological Sciences, 2019
QTc prolongation has been observed during arsenic trioxide and realgar's clinical use, and become a huge obstacle for the application. Our lab has obtained the soluble arsenic from realgar named realgar transforming solution or RTS.
Yang Hai, Peng Song, Xin Wang, Longhe Zhao, Qinjian Xie, Jianyin Li, Yang Li, Hongyu Li   +7 more
doaj   +1 more source

Arsenic Trioxide Inhibits Cell Growth and Induces Apoptosis through Inactivation of Notch Signaling Pathway in Breast Cancer [PDF]

, 2012
Arsenic trioxide has been reported to inhibit cell growth and induce apoptotic cell death in many human cancer cells including breast cancer. However, the precise molecular mechanisms underlying the anti-tumor activity of arsenic trioxide are still ...
Ahmad, Aamir, Bao, Bin, Chen, Zhiwen, Li, Youjian, Mei, Chuanzhong, Miele, Lucio, Sarkar, Fazlul H, Wang, Zhiwei, Xia, Jun, Yang, Qingling   +9 more
core   +2 more sources

Inorganic arsenic trioxide induces gap junction loss in association with the downregulation of connexin43 and E-cadherin in rat hepatic “stem-like” cells

Kaohsiung Journal of Medical Sciences, 2014
Chronic exposure to inorganic arsenic trioxide causes tumors of the skin, urinary bladder, lung, and liver. Several cancer initiators and promoters have been shown to alter cell–cell signaling by interference with gap junction intercellular communication
Pi-Jung Hsiao, Jo-Chi Jao, Jin-Lian Tsai, Wen-Tsan Chang, Kuo-Shyang Jeng, Kung-Kai Kuo   +5 more
doaj   +1 more source

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro [PDF]

, 2013
Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue.
Chen, Rongchang, Dong, Xi, Luo, Yun, Qin, Meng, Sun, Guibo, Sun, Hong, Sun, Xiaobo, Wang, Min, Wu, Ping, Yao, Fan, Zhang, Qiang   +10 more
core   +3 more sources

Genomic landscapes and clonality of de novo AML [PDF]

, 2013
No abstract ...
Brewin, John, Chevassut, Timothy, Horne, Gillian   +2 more
core   +1 more source

Targeting GLI factors to inhibit the Hedgehog pathway [PDF]

, 2015
Hedgehog (Hh) signaling has emerged in recent years as an attractive target for anticancer therapy because its aberrant activation is implicated in several cancers. Major progress has been made in the development of SMOOTHENED (SMO) antagonists, although
Alfonsi, Romina, Botta, Bruno, DI MARCOTULLIO, Lucia, Infante, Paola, Mori, Mattia   +4 more
core   +2 more sources

The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel

BMC Medical Genomics, 2010
Background Drinking water contaminated with inorganic arsenic is associated with increased risk for different types of cancer. Paradoxically, arsenic trioxide can also be used to induce remission in patients with acute promyelocytic leukemia (APL) with a
Liu Qian, Zhang Hao, Smeester Lisa, Zou Fei, Kesic Matt, Jaspers Ilona, Pi Jingbo, Fry Rebecca C   +7 more
doaj   +1 more source