Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]
, 2017 Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo +23 more
core +4 more sources
PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]
, 2014 Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Beech +34 more
core +4 more sources
Advanced Science, 2019 The latent viral reservoir is the source of viral rebound after interruption of antiretroviral therapy (ART) and is the major obstacle in eradicating the latent human immunodeficiency virus‐1 (HIV‐1).
Qing Yang +16 more
doaj +1 more source
Addition of Arsenic Trioxide into Induction Regimens Could Not Accelerate Recovery of Abnormality of Coagulation and Fibrinolysis in Patients with Acute Promyelocytic Leukemia. [PDF]
PLoS ONE, 2016 AIM:All-trans retinoic acid combined to anthracycline-based chemotherapy is the standard regimen of acute promyelocytic leukemia. The advent of arsenic trioxide has contributed to improve the anti-leukemic efficacy in acute promyelocytic leukemia.
Ye Zhang +4 more
doaj +1 more source
Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]
, 2012 In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Beez, Sabine +2 more
core +3 more sources
E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma [PDF]
, 2014 Lung cancer is one of the most common cancers worldwide. Arsenic trioxide (ATO) has been approved by the U.S. Food and Drug Administration for the treatment of acute promyelocytic leukemia.
Ho, JCM +4 more
core +1 more source
Arsenic trioxide as a novel anti-glioma drug: a review
Cellular & Molecular Biology Letters, 2020 Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown.
Yi Fang, Zhen Zhang
doaj +1 more source
口腔疾病防治, 2023 Objective To investigate the etiology, clinical manifestations, treatment and prevention of jaw necrosis caused by arsenic trioxide to provide a reference for clinical diagnosis and treatment.
WANG Liping +2 more
doaj +1 more source
Arsenic Trioxide Compound Modulates Multiple Myeloma Phenotypes: Assessment on Cell Line Models [PDF]
Iranian Journal of Public Health, 2006 Recent evidences suggest that multiple myeloma phenotypes (MMPs) are involved in the infiltration of multiple myeloma-affected marrow foci. In this study, the effects of arsenic trioxide on the invasive and angiogenic phenotypes of multiple myeloma (MM ...
MR Khorramizadeh +9 more
doaj +2 more sources
Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers [PDF]
, 2017 Since arsenic trioxide (ATO) was first approved as the front line therapy for acute promyelocytic leukemia (APL) 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation.
Akhtar, Anam +4 more
core +1 more source