Results 11 to 20 of about 30,301 (244)

Severe acute axonal neuropathy following treatment with arsenic trioxide for acute promyelocytic leukemia: a case report [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2016
Peripheral neuropathy is a common complication of arsenic toxicity. Symptoms are usually mild and reversible following discontinuation of treatment. A more severe chronic sensorimotor polyneuropathy characterized by distal axonal-loss neuropathy can be ...
Marcus Kuhn, Mithia Nabergoj, Kety Sammartin, Fabrizio Vianello   +3 more
doaj   +5 more sources

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma [PDF]

Molecular Cancer, 2014
Background: Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide was poorly effective against ...
Chen, Xi, Jiang, Hongchi, Li, Yuejin, Liang, Yingjian, Liu, Jiaren, Liu, Lianxin, Lu, Zhaoyang, Meng, Xianzhi, Pan, Shangha, Qi, Shuyi, Song, Xuan, Sun, Boshi, Wang, Jiabei, Xie, Changming, Yin, Dalong, Zheng, Tongsen   +15 more
core   +4 more sources

Influence of white blood cell count trajectories on the risk of differentiation syndrome during induction therapy with all-trans-retinoic acid and arsenic trioxide in pediatric acute promyelocytic leukemia. [PDF]

Front Pediatr
Fu H, Liu Y, Hu S.
europepmc   +3 more sources

Factors determining sensitivity and resistance of tumor cells to arsenic trioxide. [PDF]

PLoS ONE, 2012
Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide.
Serkan Sertel, Margaret Tome, Margaret M Briehl, Judith Bauer, Kai Hock, Peter K Plinkert, Thomas Efferth   +6 more
doaj   +1 more source

Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats

Asian Pacific Journal of Tropical Biomedicine, 2023
Objective: To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats. Methods: Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days.
Gayatri Khuntia, Jeevan Ranjan Dash, Biswadeep Jena, Uma Kanta Mishra, Subash Chandra Parija   +4 more
doaj   +1 more source

Neuroblastoma Cell Death is Induced by Inorganic Arsenic Trioxide (As2O3) and Inhibited by a Normal Human Bone Marrow Cell-Derived Factor [PDF]

, 2008
Benjamin Gesundheit, Lea Malach, Reuven Or, Talia Hahn, RP Castleberry, KK Matthay, M Lastowska, JD Walton, SG DuBois, T Hahn, Y Gazitt, XH Zhu, B Gesundheit, HM Pettersson, J Karlsson, J Karlsson, Y Akao, I Øra, NW Roehm, SM Frisch, A Ben-Ze'ev, Z Kuci   +21 more
core   +3 more sources

Phase I/II trial of local interstitial chemotherapy with arsenic trioxide in patients with newly diagnosed glioma

Frontiers in Neurology, 2022
BackgroundGlioma is the most common primary brain tumor in adults with poor prognosis. The glioma patients benefit from STUPP strategy, including maximum and safe resection and adjuvant radiotherapy and chemotherapy.
Dayong Han, Dayong Han, Dayong Han, Lei Teng, Lei Teng, Lei Teng, Xiaoxiong Wang, Xiaoxiong Wang, Xiaoxiong Wang, Yunbo Zhen, Yunbo Zhen, Yunbo Zhen, Xiaofeng Chen, Xiaofeng Chen, Xiaofeng Chen, Mingchun Yang, Mingchun Yang, Mingchun Yang, Ming Gao, Ming Gao, Ming Gao, Guang Yang, Guang Yang, Guang Yang, Mingyang Han, Ligang Wang, Ligang Wang, Ligang Wang, Jiajun Xu, Jiajun Xu, Jiajun Xu, Yue Li, Alina Shumadalova, Shiguang Zhao, Shiguang Zhao, Shiguang Zhao, Shiguang Zhao   +36 more
doaj   +1 more source

UNC13B Promote Arsenic Trioxide Resistance in Chronic Lymphoid Leukemia Through Mitochondria Quality Control

Frontiers in Oncology, 2022
In clinical practice, arsenic trioxide can be used to treat a subset of R/R CML patients, but resistance tends to reappear quickly. We designed an experiment to study arsenic trioxide resistance in K-562 cells.
Xiao-Bo Wang, Li-Hua Yuan, Le-Ping Yan, Yong-Bin Ye, Bo Lu, Xiaojun Xu   +5 more
doaj   +1 more source

An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications

Cell Death Discovery, 2023
Arsenic trioxide is a first-line treatment drug for acute promyelocytic leukemia, which is also effective for other kinds of leukemia. Its side effects, however, limit its clinical application, especially for patients with complex leukemia symptoms ...
Yanan Jiang, Xiuyun Shen, Fengnan Zhi, Zhengchao Wen, Yang Gao, Juan Xu, Baofeng Yang, Yunlong Bai   +7 more
doaj   +1 more source

Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. [PDF]

PLoS ONE, 2012
Estrogen receptor α (ERα) is a marker predictive for response of breast cancers to endocrine therapy. About 30% of breast cancers, however, are hormone- independent because of lack of ERα expression. New strategies are needed for re-expression of ERα and
Juan Du, Nannan Zhou, Hongxia Liu, Fei Jiang, Yubang Wang, Chunyan Hu, Hong Qi, Caiyun Zhong, Xinru Wang, Zhong Li   +9 more
doaj   +1 more source