Results 51 to 60 of about 30,301 (244)
Combined Toxicity and Bioconcentration of Fluoride and Arsenic in African Catfish Clarias gariepinus (Burchell, 1822) [PDF]
, 2017 Laboratory experiments were performed to examine the combined toxic effects of two important aquatic contaminants viz., arsenic and fluoride on African catfish, Clarias gariepinus.
Pervez, S. (Shamsh) +2 more
core +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Haematologica, 2020 Daily intravenous arsenic trioxide administered with all-trans retinoid acid, the standard-of-care for acute promyelocytic leukemia, is costly and challenging to administer.
Farhad Ravandi +13 more
doaj +1 more source
Arsenic induced genotoxic and histopathological changes in male Swiss albino mice, Mus musculus [PDF]
, 2011 The present study was carried out to investigate the effect of arsenic trioxide on the DNA and histomorphology of testis, liver and kidney of Swiss albino mice, Mus musculus. Oral administration of arsenic trioxide induced DNA damage in the testis, liver
Mohapatra, Animesh K. +2 more
core +2 more sources
Cell Proliferation, EarlyView.We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang +12 more
wiley +1 more source
COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY ARTHRITIS [PDF]
, 2012 Methods for treating or preventing one or more symptoms of rheumatoid arthritis or other types of inflammatory arthritis involves administering a formulation containing an effective amount of arsenic trioxide to an affected patient.
core
Supplementary Data from A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer [PDF]
, 2023 Richard W. Ahn +10 more
openalex +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Aim Hydraulic calcium silicate cements are widely employed in endodontics due to their excellent biocompatibility, bioactivity, sealing ability, and remineralisation potential. However, currently used products such as mineral trioxide aggregate (MTA) exhibit several limitations, including discolouration, cost, and poor handling properties ...
P. A. A. S. Prasad Kumara +6 more
wiley +1 more source
Effect of arsenic trioxide (Trisenox) on actin organization in K-562 erythroleukemia cells.
Folia Histochemica et Cytobiologica, 2010 Actin is one of the cytoskeletal proteins that take part in many cellular processes. The aim of this study was to show the influence of Trisenox (arsenic trioxide), on the cytoplasmic and nuclear F-actin organization. Arsenic trioxide is the proapoptotic
Dariusz Grzanka +4 more
doaj +1 more source