Results 71 to 80 of about 13,610 (191)

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, Volume 2, Issue 2, Page 343-370, June 2026.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Presenting features and treatment outcome of acute promyelocytic leukemia arising after multiple sclerosis

Haematologica, 2011
We report the clinical features and treatment outcome of 33 patients with multiple sclerosis who developed acute promyelocytic leukemia. Thirty patients were previously exposed to mitoxantrone.
Emanuele Ammatuna, Pau Montesinos, Syed Khizer Hasan, Safaa M. Ramadan, Jordi Esteve, Maximillian Hubmann, Maria Pagoni, David Grimwade, Miguel Angel Sanz, Francesco Lo-Coco   +9 more
doaj   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Engineering of Amygdalin Biosynthesis in Rice Endosperm for Pharmaceutical Production and Sitophilus oryzae Resistance

Plant Biotechnology Journal, EarlyView.
Ke Chen, Nan Chai, Shaotong Chen, Chanjuan Ye, Kangli Sun, Jie Guo, Xinqiao Zhou, Dagang Chen, Juan Liu, Yanduan Hu, Yi Zou, Rui Cao, Shu Jiang, Bocai Tang, Qinlong Zhu, Chuanguang Liu, Jiantao Tan   +16 more
wiley   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Formulation of oral compositions comprising arsenic trioxide and methods of use thereof [PDF]

, 2004
The present invention provides an oral formulation of arsenic trioxide (As2O3) for the treatment of a variety of hematological malignancies, including acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

core   +3 more sources

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, Volume 59, Issue 6, June 2026.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Rapid Reduction in Breast Cancer Mortality With Inorganic Arsenic in Drinking Water

EBioMedicine, 2014
Background: Arsenic trioxide is effective in treating promyelocytic leukemia, and laboratory studies demonstrate that arsenic trioxide causes apoptosis of human breast cancer cells.
Allan H. Smith, Guillermo Marshall, Yan Yuan, Craig Steinmaus, Jane Liaw, Martyn T. Smith, Lily Wood, Marissa Heirich, Rebecca M. Fritzemeier, Mark D. Pegram, Catterina Ferreccio   +10 more
doaj   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Size Control of Arsenic Trioxide Nanocrystals Grown in Nanowells

, 2016
Size Control of Arsenic Trioxide Nanocrystals Grown in ...
Thomas V. O’Halloran (392208), Teri W. Odom (1234350), Meera R. Raja (392200), Richard W. Ahn (392198), Min Hyung Lee (1431634), Eun-Ah You (2110147)   +5 more
core   +1 more source