Results 31 to 40 of about 8,884 (302)

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei [PDF]

, 2015
Drug resistance in pathogenic protozoa is very often caused by changes to the ‘transportome’ of the parasites. In Trypanosoma brucei, several transporters have been implicated in uptake of the main classes of drugs, diamidines and melaminophenyl ...
De Koning, Harry P., Munday, Jane C., Settimo, Luca   +2 more
core   +1 more source

The gut microbiome promotes arsenic metabolism and alleviates the metabolic disorder for their mammal host under arsenic exposure

Environment International, 2023
Gut microbiome can participate in arsenic metabolism. However, its efficacy in the host under arsenic stress is still controversial. To clarify their roles in fecal arsenic excretion, tissue arsenic accumulation, host physiological states and metabolism,
Linkang Chen, Chengji Li, Xiaoting Zhong, Chengze Lai, Bin Zhang, Yu Luo, Honghui Guo, Keqing Liang, Jingwen Fang, Xuan Zhu, Jingjing Zhang, Lianxian Guo   +11 more
doaj   +1 more source

Bioaccumulation, biotransformation and trophic transfer of arsenic in the aquatic food chain [PDF]

, 2012
The occurrence, distribution, speciation, and biotransformation of arsenic in aquatic environment (marine and freshwater) have been studied extensively by several research groups during last couple of decades.
Azizur Rahman, M, Hasegawa, H, Peter Lim, R   +2 more
core   +1 more source

Arsenic Methyltransferase and Methylation of Inorganic Arsenic [PDF]

Biomolecules, 2020
Arsenic occurs naturally in the environment, and exists predominantly as inorganic arsenite (As (III) and arsenate As (V)). Arsenic contamination of drinking water has long been recognized as a major global health concern. Arsenic exposure causes changes in skin color and lesions, and more severe health conditions such as black foot disease as well as ...
Nirmal K. Roy, Anthony Murphy, Max Costa
openaire   +3 more sources

Speciation of arsenic metabolites in the urine of occupational workers and experimental rats using an optimised hydride cold-trapping method [PDF]

, 1998
A hydride cold-trapping technique was developed and optimised for the measurement of urinary arsenic metabolites. The analytical precision of the method was found to be 6.1, 4.0 and 4.8% (n = 5) for inorganic arsenic (As-i), monomethylarsonate (MMA) and ...
ChiswellB, ImrayP, JohnsonD, MooreMR, Ng, JC   +4 more
core   +1 more source

Pharmacokinetic and Genomic Effects of Arsenite in Drinking Water on Mouse Lung in a 30-Day Exposure

Dose-Response, 2015
The 2 objectives of this subchronic study were to determine the arsenite drinking water exposure dependent increases in female C3H mouse liver and lung tissue arsenicals and to characterize the dose response (to 0, 0.05, 0.25, 1, 10, and 85 ppm arsenite ...
Jaya Chilakapati, Kathleen Wallace, Araceli Hernandez-Zavala, Tanya Moore, Hongzu Ren, Kirk T. Kitchin   +5 more
doaj   +1 more source

Synthesis and applications of protein/peptide-polymer conjugates [PDF]

, 2017
Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with ...
Abuchowski, Akers, Aksakal, Alconcel, Alconcel, Alsubaie, Alsubaie, Anastasaki, Anastasaki, Anastasaki, Anastasaki, Antonik, Avanti, Barnes, Basuki, Biswas, Boerakker, Bontempo, Cao, Chabrol, Church, Cobo, Collins, Collins, Collins, Das, Delplace, Engelis, Godula, Gody, Gody, Goodwin, Griebenow, Guegain, Gunawan, Hibi, Hill, Ho, Hou, Ida, Isahak, Isarov, Isarov, Johnson, Jones, Jones, Jones, Jones, Jones, Keddie, Keefe, Kim, Kuan, Lee, Li, Lin, Lloyd, Loczenski Rose, Lundquist, Lutz, Manoharan, Matyjaszewski, McHale, McKenzie, McRae, Miyata, Moelbert, Muttenthaler, Nicolas, Nikolaou, Pfeifer, Rademacher, Richards, Robin, Robin, Ruehl, Ryan, Schmitz, Schumacher, Seki, Shaunak, Silva, Simula, Simula, Simula, Singha, Smith, Soeriyadi, Spicer, Steinbach, Stenzel, Tang, Tao, Teo, Tong, Trinh, Tseng, Vandenbergh, Velkov, Villar, Waldron, Walsh, Wei, Whittaker, Wilson, Wilson, Wisśniewski, Wurm, Yasayan, York, Zamfir, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhu   +121 more
core   +1 more source

A State-of-the-Science Review of Arsenic's Effects on Glucose Homeostasis in Experimental Models. [PDF]

, 2020
BackgroundThe prevalence of type 2 diabetes (T2D) has more than doubled since 1980. Poor nutrition, sedentary lifestyle, and obesity are among the primary risk factors.
Castriota, Felicia, Dahlberg, Sarah, La Merrill, Michele A, Rieswijk, Linda, Smith, Martyn T, Steinmaus, Craig, Wang, Jen-Chywan   +6 more
core   +2 more sources

Critical evaluations of different aspects involved in preparation of Hartala bhasma

International Journal of Ayurveda Research, 2023
Arsenic trisulfide, known as Hartala (~Orpiment), is being used as medicine since the time of Hippocrates. However, the use of arsenicals in modern medicine is constrained due to toxicology concerns. Ayurveda has used orpiment as medicine since 2000 B.C.
Piyush Krantikumar Gandhi, Rajesh Kundlikrao Ingole   +1 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source