Results 41 to 50 of about 4,489 (165)

High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals

open access: yesSLAS Discovery
Warfare arsenicals are potent blistering agents and cause severe inflammation following their skin exposure. Data from our group (unpublished) show that these chemicals act by activating bromodomain-4 and RIPK signaling.
Marina Fosso Yatchang   +14 more
doaj   +1 more source

Arsenic in Cancer Treatment: Challenges for Application of Realgar Nanoparticles (A Minireview)

open access: yesToxins, 2010
While intensive efforts have been made for the treatment of cancer, this disease is still the second leading cause of death in many countries. Metastatic breast cancer, late-stage colon cancer, malignant melanoma, multiple myeloma, and other forms of ...
Peter Baláž, Ján Sedlák
doaj   +1 more source

Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice

open access: yesEcotoxicology and Environmental Safety, 2021
Long-term consumption of arsenic-contaminated rice has become a public health issue that urgently needs to be addressed. In this study, mice were exposed to arsenic in rice (low dose, 0.91 mg/kg; medium dose, 9.1 mg/kg) for 30 days and 60 days ...
Fubin Chen   +11 more
doaj   +1 more source

Advances in the safety evaluation of mineral medicines - Cinnabar and Realgar

open access: yesWorld Journal of Traditional Chinese Medicine, 2019
Mineral medicines have a long history in the treatment of diseases. Among these, cinnabar and realgar are the most commonly used. This review discusses the differences between cinnabar and realgar and other mercurials and arsenicals.
Jing-Zhuo Tian   +6 more
doaj   +1 more source

Arsenic levels in humans and water sources for human consumption in Peru: A systematic review

open access: yesSouth Sustainability
In Peru, the high toxicity of arsenic constitutes a public health issue; however, data on its presence in water and human biomarkers is limited. The aim of this systematic review was to synthesize the evidence regarding reported arsenic levels in humans
Rocio Lorena Adama Victorio   +5 more
doaj   +1 more source

Impact of Inorganic Arsenicals on Vegetative Growth of Two Pakistani Origins Sunflower Cultivars

open access: yesJournal of Chemistry, 2015
Inorganic arsenicals impact on vegetative growth of two sunflower (Helianthus annuus L.) cultivars (FH-385 as Hybrid 1 and FH-405 as Hybrid 2) was monitored. Various levels of two different sodium salts of arsenic, namely, sodium arsenate (Na2HAsO4·7H2O)
Muhammad Asif Imran   +4 more
doaj   +1 more source

Assessment of museum staff exposure to arsenic while handling contaminated exhibits by urinalysis of arsenic species

open access: yesJournal of Occupational Medicine and Toxicology, 2017
Preservation of museum objects with inorganic arsenic compounds and contamination of the surroundings has previously been documented. The present study addresses the exposure of museum staff by measuring arsenicals in urine. After 1 week without exposure,
Amanda Mithander   +3 more
doaj   +1 more source

Challenges for application of realgar: A critical review

open access: yesBLDE University Journal of Health Sciences, 2016
Realgar has been not only well-known poisons but also used as healing agent. Realgar has long been used in traditional medicines for different diseases; so far arsenic can be extremely toxic and carcinogenic.
Vineet Sharma   +2 more
doaj   +1 more source

Toxicological Characterization of the Inorganic and Organic Arsenic Metabolite Thio-DMAV in Cultured Human Lung Cells

open access: yesJournal of Toxicology, 2011
We synthesised and toxicologically characterised the arsenic metabolite thiodimethylarsinic acid (thio-DMAV). Successful synthesis of highly pure thio-DMAV was confirmed by state-of-the-art analytical techniques including H1-NMR, HPLC-FTMS, and HPLC ...
Marc Bartel   +4 more
doaj   +1 more source

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