Results 51 to 60 of about 12,135 (165)

Severe Plasmodium vivax Malaria Complicated by Secondary Hemophagocytic Lymphohistiocytosis, Disseminated Intravascular Coagulation, and Acute Pancreatitis: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Plasmodium vivax (P. vivax) malaria, once regarded as a comparatively benign infection, is increasingly recognized as a cause of severe, potentially life‐threatening multisystem disease. Concurrent secondary hemophagocytic lymphohistiocytosis (HLH), disseminated intravascular coagulation (DIC), and acute pancreatitis complicating P.
Tasnim Nafian, Md. Abul Kalam Azad, Khaled Mahbub Murshed, Kazi Ali Aftab, Rubayet Shahriar, Abdullah Al Faisal   +5 more
wiley   +1 more source

Use of artemether-lumefantrine in the treatment of asymptomatic-malaria infection in HIV-positive and HIVnegative Nigerian adults. [PDF]

Malaria /HIV co-infection is a major challenge to public health in developing countries and yet potential drug-drug interactions between antimalarial and antiviral regimens have not been adequately investigated in people with both HIV and Plasmodium ...
Chijioke-Nwauche, IN
core   +1 more source

CYP2B6*6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers [PDF]

, 2020
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of the antimalarial drugs artemether and lumefantrine. Here we investigated the effect of CYP2B6*6 on the plasma pharmacokinetics of artemether, lumefantrine, and their metabolites in healthy ...
Winterberg, Markus, Bakare-Odunola, Moji T, Khoo, Saye, Adeniyi Olagunju, Andrew Owen, Moji T. Bakare‐Odunola, Bolarinwa, Rahman A, Owen, Andrew, Saye Khoo, Soyinka, Julius O, Tarning, Joel, Olagunju, Adeniyi, Rahman A. Bolarinwa, Abdullahi, Sa'ad T, Julius O. Soyinka, Markus Winterberg, Sa'ad T. Abdullahi, Joel Tarning, Olarewaju, Olusola J, Olusola J. Olarewaju   +19 more
core   +1 more source

Usefulness of combined screening methods for rapid detection of falsified and/or substandard medicines in the absence of a confirmatory method

Malaria Journal, 2019
Background The influx of substandard and falsified medicines is a global public health challenge and its rapid detection is a key solution to the menace. This study used three screening methods and one confirmatory method for the quality assessment of 25
Kwabena Frimpong-Manso Opuni, Henry Nettey, Marvin Adjei Larbi, Salome Naa Amerley Amartey, Gifty Nti, Abraham Dzidonu, Patrick Owusu-Danso, Nicholas Amoah Owusu, Alexander Kwadwo Nyarko   +8 more
doaj   +1 more source

Malaria‐Associated Secondary Hematophagocytic Lymphohistocytosis—A Case Report and Comprehensive Literature Review (sHLH)

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Malaria‐associated secondary HLH, though rare, is often overlooked. Clinicians should maintain a high‐index of suspicion in travelers returning from malaria‐endemic regions who develop severe to rapidly worsening inflammatory illness, as early recognition is critical for survival.
Indresh Yadav, Sulav Kumar Jha, Sweta Singh, Dipesh Kumar Mandal, Saurav Jha   +4 more
wiley   +1 more source

Safety of artemether-lumefantrine exposure in first trimester of pregnancy : an observational cohort [PDF]

, 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
Abdulla, Salim, Sigilbert Mrema, Dominic Mosha, Salim Abdulla, Sevene, Esperanca, Mosha, D., Mrema, Sigilbert, Mazuguni, F., Abdulla, S., Esperanca Sevene, Blaise Genton, Mosha, Dominic, Mazuguni, Festo, Festo Mazuguni, Sevene, E., Genton, B., Genton, Blaise, Mrema, S.   +17 more
core   +1 more source

Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations

Beni-Suef University Journal of Basic and Applied Sciences
Background The lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of artemether and lumefantrine. However, the observed kinetic instability (propensity of lumefantrine to rapid
Onyinyechi Lydia Ugorji, Ikechukwu Virgilius Onyishi, Julie Ngozichukwuka Onwodi, Christiania Moji Adeyeye, Uzochukwu Gospel Ukachukwu, Nicholas Chinedu Obitte   +5 more
doaj   +1 more source

Simultaneous Estimation of Artemether and Lumefantrine by RP-HPLC Method Development in Pharmaceutical Tablet Dosage Form

RGUHS Journal of Pharmaceutical Sciences
Background Artemether and Lumefantrine are widely used antimalarial agents whose simultaneous quantification in tablet formulations is essential for quality control.Objectives To develop and validate a simple accurate and robust ...
Lekhana A M, Paul Richards M, Vishwanath BA   +2 more
doaj   +1 more source

Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon

Malaria Journal, 2012
Background The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Mombo-Ngoma Ghyslain, Kleine Christian, Basra Arti, Würbel Heike, Diop Daisy A, Capan Mesküre, Adegnika Ayola A, Kurth Florian, Mordmüller Benjamin, Joanny Fanny, Kremsner Peter G, Ramharter Michael, Bélard Sabine   +12 more
doaj   +1 more source

Monitoring of the Sensitivity In Vivo of Plasmodium falciparum to Artemether-Lumefantrine in Mali

Tropical Medicine and Infectious Disease, 2021
In Mali, since 2007, artemether-lumefantrine has been the first choice against uncomplicated malaria. Despite its effectiveness, a rapid selection of markers of resistance to partner drugs has been documented.
Modibo Diarra, Drissa Coulibaly, Amadou Tapily, Boureima Guindo, Koualy Sanogo, Diakalia Koné, Youssouf Koné, Karim Koné, Aboudramane Bathily, Oumar Yattara, Mahamadou A. Thera, Alassane Dicko, Abdoulaye A. Djimdé, Issaka Sagara   +13 more
doaj   +1 more source