Results 71 to 80 of about 12,135 (165)

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1179-1194, May 2026.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana

Journal of Tropical Medicine, 2019
Infants and children under five years generally have high susceptibility to pathogenic and opportunistic infections due to immaturity and inexperience of their immune responses.
Solomon Opoku, Isaac Nyanor
doaj   +1 more source

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Pharmaceutics, 2021
Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes [PDF]

, 2020
There is an increased recognition of the need to identify and quantify the impact of genetic polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of the pharmacokinetic drug-drug interaction between nevirapine and ...
Winterberg, Markus, Bakare-Odunola, Moji T, Khoo, Saye, Bolarinwa, Rahman A, Owen, Andrew, Soyinka, Julius O, Tarning, Joel, Olagunju, Adeniyi, Abdullahi, Sa'ad T, Olarewaju, Olusola J   +9 more
core   +1 more source

A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand

Malaria Journal, 2005
Background The use of antimalarial drug combinations with artemisinin derivatives is recommended to overcome drug resistance in Plasmodium falciparum.
McGready Rose, Ashley Elizabeth A, Paiphun Lucy, Hutagalung Robert, Brockman Alan, Thwai Kaw L, Singhasivanon Pratap, Jelinek Thomas, White Nicholas J, Nosten François H   +9 more
doaj   +1 more source

Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India

Malaria Journal, 2021
Background Malaria is a major public health problem in India and accounts for about 88% of malaria burden in South-East Asia. India alone accounted for 2% of total malaria cases globally.
Sri Krishna, Sweta Mishra, Prakash Tiwari, Anup K. Vishwakarma, Sushrikanta Khandai, Suyesh Shrivastava, Anil K. Verma, Shashikant Tiwari, Hari Barman, Surendra Jhariya, Pradeep Tiwari, Anup S. Tidgam, Brij M. Varun, Sunil Singh, Naresh Yerane, Chintaman R. Tembhurne, Prem L. Mandavi, Shyam S. Tekam, Manas Malik, Kali P. Behera, Himanshu Jayswar, Khemraj Sonwani, Mukund S. Diggikar, Madan M. Pradhan, Sher S. Khasotiya, Avdhesh Kumar, Neeraj Dhingra, Maria Dorina G. Bustos, Eva-Maria Christophel, Pascal Ringwald, Roop Kumari, Man M. Shukla, Neeru Singh, Aparup Das, Praveen K. Bharti   +34 more
doaj   +1 more source

Complete Dialysis‐Free Recovery From Severe Malaria–Associated Acute Kidney Injury and Multiorgan Failure: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Severe malaria remains a major cause of acute kidney injury and multiorgan failure in endemic regions, often requiring renal replacement therapy. However, access to dialysis is limited in many resource‐constrained settings, making outcomes highly dependent on early diagnosis and effective antimalarial treatment. We report a 32‐year‐old man who
Tamirat Godebo Woyimo, Amare Hailu Ashine, Mohammed Kedir Shukri, Yonas Damtew Bejiga, Ragasa Getachew, Yosef Bekele Bonsa, Rediet Girmaye, Tsion Haile Woldemariam, Adugna Lamessa   +8 more
wiley   +1 more source

Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults.

, 2016
OBJECTIVES: Co-administration of artemether/lumefantrine with antiretroviral therapy has potential for pharmacokinetic drug interactions. We investigated drug-drug interactions between artemether/lumefantrine and efavirenz or nevirapine.

core   +1 more source

Artemether-Lumefantrine Pharmacokinetics and Clinical Response Are Minimally Altered in Pregnant Ugandan Women Treated for Uncomplicated Falciparum Malaria. [PDF]

, 2015
Artemether-lumefantrine is a first-line regimen for the treatment of uncomplicated malaria during the second and third trimesters of pregnancy. Previous studies have reported changes in the pharmacokinetics and clinical outcomes following treatment with ...
Huang, Liusheng, Parikh, Sunil, Aweeka, Francesca, Nguyen, Vy K, Mwima, Moses W, Achan, Jane, Mwebaza, Norah, Kajubi, Richard, Nyunt, Myaing M, Ssebuliba, Joshua, Kiconco, Sylvia   +10 more
core   +1 more source