Results 71 to 80 of about 11,901 (167)

Physiologically‐Based Pharmacokinetic Modeling to Investigate Piperaquine Exposure in Pregnant Women Using an Individualized Profile Approach

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Malaria in pregnancy poses significant risks to the mother, fetus, and neonate, necessitating effective treatment and prevention strategies. This study explored the application of an individualized (‘virtual twin’) physiologically‐based pharmacokinetic (PBPK) modeling approach to the antimalarial drug piperaquine in pregnant women.
Sonia Khier, Myriam El Gaaloul, Joel Tarning, Nada Abla   +3 more
wiley   +1 more source

Triple therapy with artemether-lumefantrine plus amodiaquine versus artemether-lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial [PDF]

, 2022
Background: Late treatment failures after artemisinin-based combination therapies (ACTs) for falciparum malaria have increased in the Greater Mekong subregion in southeast Asia.
Hien, Tran Tinh, White, Nicholas J., Sovann, Yok, Callery, James J., Maude, Richard J., Van Luong, Vo, Amaratunga, Chanaki, Peto, Thomas J, Duanguppama, Jureeporn, Tripura, Rupam, Sokha, Meas, Day, Nicholas P. J., Ruecker, Andrea, White, Nicholas J, Chau, Nguyen Hoang, Thuong, Nguyen Thi Huyen, Long, Le Thanh, Mukaka, Mavuto, Dondorp, Arjen M., Callery, James J, Tarning, Joel, Hoglund, Richard M, Peto, Thomas J., Miotto, Olivo, Day, Nicholas PJ, Hoglund, Richard M., van der Pluijm, Rob W., Dondorp, Arjen M, Chotsiri, Palang, Waithira, Naomi, Callery, James, Luong, Vo Van, Imwong, Mallika, Day, Nicholas P J, Dhorda, Mehul, Lek, Dysoley, van der Pluijm, Rob W, Chotivanich, Kesinee, Nguon, Chea, von Seidlein, Lorenz, Dung, Nguyen Thi Phuong, Rekol, Huy, Maude, Richard J, Nghia, Ho Dang Trung   +43 more
core   +1 more source

Reduction of malaria transmission to Anopheles mosquitoes with a six-dose regimen of co-artemether. [PDF]

, 2005
BACKGROUND: Resistance of malaria parasites to chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) is increasing in prevalence in Africa. Combination therapy can both improve treatment and provide important public health benefits if it curbs the spread ...
Neal Alexander (18417), Colin J Sutherland (18042), Christopher J Drakeley (58257), Rosalind Coleman (18415), Targett Geoffrey A. T, Sutherland Colin J, Gijs Walraven (18413), Jawara, Musa, Coleman, Rosalind, Sam Dunyo, Musa Jawara (18412), Alexander Neal, Geoffrey A T Targett, Sutherland, Colin J, Ord Rosalynn, Musa Jawara, Coleman Rosalind, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Targett, Geoffrey AT, Rosalynn Ord (18410), Geoffrey A. T Targett (18418), Neal Alexander, Colin J Sutherland, Sam Dunyo (58256), Rosalind Coleman, Margaret Pinder (1712), Gijs Walraven, Walraven Gijs, Drakeley, Christopher J, Alexander, Neal, Margaret Pinder, Dunyo Sam, Dunyo, Sam, Rosalynn Ord, Christopher J Drakeley, Drakeley Christopher J, Pinder, Margaret   +39 more
core   +1 more source

Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort. [PDF]

, 2014
There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
Abdulla, Salim, Sigilbert Mrema, Dominic Mosha, Salim Abdulla, Sevene, Esperanca, Mosha, D., Mrema, Sigilbert, Mazuguni, F., Abdulla, S., Esperanca Sevene, Blaise Genton, Mosha, Dominic, Mazuguni, Festo, Festo Mazuguni, Sevene, E., Genton, B., Genton, Blaise, Mrema, S.   +17 more
core   +1 more source

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Co-administered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults

, 2022
Despite repeated malaria infection, individuals living in malaria endemic areas remain vulnerable to re-infection. The Janus kinase (JAK1/2) inhibitor ruxolitinib could potentially disrupt the parasite-induced dysfunctional immune response when ...
El Gaaloul, Myriam, Kress, Anita, Wells, Timothy, van Giersbergen, Paul, McCarthy, James S, Barnes, Karen I, Abla, Nada, Chughlay, M Farouk, Griffin, Paul, Schultz, Hayley B, Tapley, Peter, Möhrle, Jörg J, Engwerda, Christian R., Reuter, Stephanie E, et al., Webster, Rebecca A   +15 more
core   +1 more source

Qualitative and Quantitative Microbiological Studies of Paediatric Artemether-Lumefantrine Dry Powders and Paracetamol Syrups Obtained from Selected Drug Stores in Accra, Ghana

Journal of Tropical Medicine, 2019
Infants and children under five years generally have high susceptibility to pathogenic and opportunistic infections due to immaturity and inexperience of their immune responses.
Solomon Opoku, Isaac Nyanor
doaj   +1 more source

Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion

Pharmaceutics, 2021
Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins, Lissinda H. du Plessis, Joe M. Viljoen   +2 more
doaj   +1 more source

Complete Dialysis‐Free Recovery From Severe Malaria–Associated Acute Kidney Injury and Multiorgan Failure: A Case Report and Brief Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Severe malaria remains a major cause of acute kidney injury and multiorgan failure in endemic regions, often requiring renal replacement therapy. However, access to dialysis is limited in many resource‐constrained settings, making outcomes highly dependent on early diagnosis and effective antimalarial treatment. We report a 32‐year‐old man who
Tamirat Godebo Woyimo, Amare Hailu Ashine, Mohammed Kedir Shukri, Yonas Damtew Bejiga, Ragasa Getachew, Yosef Bekele Bonsa, Rediet Girmaye, Tsion Haile Woldemariam, Adugna Lamessa   +8 more
wiley   +1 more source

Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trial. [PDF]

, 2013
BACKGROUND: Artemisinin-based combination therapy (ACT) reduces the potential for malaria transmission, compared with non-ACTs. It is unclear whether this effect differs between ACTs.
Sauerwein, Robert W, Drakeley, Chris J, Bousema, Teun, Kavishe, R.A., Kavishe, Reginald A, Hallett, Rachel L, Mweresa, Collins K, Hermsen, C.C., Sauerwein, R.W., Shekalaghe, S., Manjurano, Alphaxard, Omar, S.A., Shekalaghe, Seif A., Sawa, Patrick, Sutherland, Colin J, Baidjoe, Amrish Y, Yussuf, R.U., Mweresa, C.K., Omar, Sabah A., Okell, L., Okell, Lucy, Hermsen, Cornelus C., Schallig, Henk DFH, Bousema, T., Manjurano, A., Baidjoe, A.Y., Mweresa, Collins K., Hallett, R.L., Beshir, Khalid B., Beshir, Khalid B, Shekalaghe, Seif A, Beshir, K.B., Drakeley, Chris J., Kavishe, Reginald A., Omar, Sabah A, Sutherland, Colin J., Yussuf, Rahma U, Sawa, P., Baidjoe, Amrish Y., Schallig, H.D., Yussuf, Rahma U., Drakeley, C., Hermsen, Cornelus C, Sutherland, C.J., Schallig, Henk D. F. H., Sauerwein, Robert W., Hallett, Rachel L.   +46 more
core   +1 more source

Population pharmacokinetics of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria in Western Kenya

British Journal of Clinical Pharmacology, Volume 92, Issue 3, Page 911-921, March 2026.
Aim This study intends to assess the pharmacokinetic properties and treatment response of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria infection in Western Kenya. Methods Seventy‐five women with uncomplicated P.
Elizabeth Juma, Junjie Ding, Martin Ongas, Nelly Koskei, Kevin Onyango, Florence Oloo, Rashid Aman, Gilbert Kokwaro, Joel Tarning, Bernhards Ogutu   +9 more
wiley   +1 more source