Results 81 to 90 of about 62,998 (285)

Simultaneous Quantitative Determination of Six Caffeoylquinic Acids in Matricaria chamomilla L. with High-Performance Liquid Chromatography

Journal of Chemistry, 2019
A simple and effective method for the simultaneous quantitative analysis of six caffeoylquinic acids (CAs) in Matricaria chamomilla L. (M. chamomilla) using high-performance liquid chromatography (HPLC) with diode-array detection (DAD) was established ...
Yifan Zhao, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Yue Bai, Dong Zhang, Lan Yang   +7 more
doaj   +1 more source

Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians [PDF]

, 2021
Almahamoudou Mahamar, Kjerstin Lanke, Wouter Graumans, Halimatou Diawara, Koualy Sanogo, Kalifa Diarra, Sidi M. Niambele, Roly Gosling, Chris Drakeley, Ingrid Chen, Alassane Dicko, Teun Bousema, Michelle E. Roh   +12 more
openalex   +1 more source

Neurotoxicity of Artemisinin Derivatives [PDF]

Clinical Infectious Diseases, 2006
tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng, Goka, Bamenla Q, Kurtzhals, Jørgen   +2 more
openaire   +3 more sources

The multifunctional autophagy pathway in the human malaria parasite, Plasmodium falciparum. [PDF]

, 2013
Autophagy is a catabolic pathway typically induced by nutrient starvation to recycle amino acids, but can also function in removing damaged organelles. In addition, this pathway plays a key role in eukaryotic development. To date, not much is known about
Bunnik, Evelien M, Cervantes, Serena, Conner, Christopher M, Escalante, Aster, Florens, Laurence, Le Roch, Karine G, Ponts, Nadia, Prudhomme, Jacques, Saraf, Anita, Sardiu, Mihaela E   +9 more
core   +4 more sources

Exploration and Characterization of the Antimalarial Activity of Pyrimidine‐2,4‐Diamines for which Resistance is Mediated by the ABCI3 Transporter

ChemMedChem, EarlyView.
Investigation of the structure‐activity relationship on W482 (1) with a pyrimidine‐2,4‐diamine scaffold culminated in analog 51 with enhanced anti‐plasmodial activity. Forward genetics and phenotypic examination revealed the ABCI3 transporter protein as a putative resistance mechanism.
Mahta Mansouri, Madeline G. Dans, Zijun Low, Katie Loi, Kate E. Jarman, Jocelyn S. Penington, Deyun Qiu, Adele M. Lehane, Benigno Crespo, Franciso‐Javier Gamo, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +14 more
wiley   +1 more source

Construction of an uricase/catalase/curcumin-co-loaded drug delivery system and its effect on hyper-uric acid-induced kidney injury

Smart Materials in Medicine
Hyper-uric acid (UA)-induced kidney injury (HAKI) is caused by the deposition of excess blood UA into the kidneys. We confined molecules of uricase (URI), catalase (CAT), and curcumin (Cur) to a single structure (UC/Cur) while retaining their enzymatic ...
Yang Zhang, Xiaobo Li, Chunling Liang, Jianjia Feng, Chuyi Yu, Weichi Jiang, Keneng Cai, Wanying Chen, Wenli Cai, Feng Zeng, Qin Xu, Peng Chen, Jianming Liang   +12 more
doaj   +1 more source

Healthcare provider and drug dispenser knowledge and adherence to guidelines for the case management of malaria in pregnancy in the context of multiple first-line artemisinin-based combination therapy in western Kenya [PDF]

, 2023
Caroline B. Osoro, Stephanie Dellicour, Eleanor Ochodo, Taryn Young, Feiko O. ter Kuile, Julie Gutman, Achille Massougbodji   +6 more
openalex   +1 more source

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Adjuik, M, Barnes, K, Day, N P J, Farrar, J, Guthmann, J P, Hien, T T, Looareesuwan, S, Mayxay, M, Myint, H Y, Nosten, F, Olliaro, P, Price, R, Pukrittayakamee, S, Smithuis, F, Stepniewska, K, Taylor, W R J, White, N J   +16 more
core   +3 more sources

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

Exploration, EarlyView.
1. Caffeic acid (CA) is a novel senomorphic. 2. Annexin A5 is the direct protein target of CA in senescent cells. 3. The covalent binding of CA to Annexin A5 protein triggers its degradation, PKCθ deactivation, and the inhibition of the NF‐κB inflammatory pathway. 4. CA effectively alleviates inflammation and lung fibrosis in mouse model.
Yinhua Zhu, Ying Zhang, Qianyu Zhang, Ping Song, Junzhe Zhang, Ang Ma, Chen Wang, Peng Gao, Tong Yang, Lirun Zhou, Qiaoli Shi, Yin Kwan Wong, Yongting Luo, Huan Tang, Jigang Wang   +14 more
wiley   +1 more source

MicroRNA-32-5p inhibits metastasis by directly targeting VPS4B and increases sensitivity to dihydroartemisinin in neuroblastoma

Science of Traditional Chinese Medicine
. Background. Neuroblastoma (NB) is a malignant pediatric tumor requiring new therapies. Accumulating evidence has confirmed that microRNAs play critical roles in NB metastasis.
Lina Chen, Hui Liu, Zhongyuan Zheng, Shuiqing Qu, Yu Zhang, Shuoqiu Deng, Shuo Shen, Tuo Liu, Yue Dai, Yu Li, Honghua Cui, Yujie Li   +11 more
doaj   +1 more source