Results 81 to 90 of about 63,940 (276)

Population pharmacokinetics of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria in Western Kenya

British Journal of Clinical Pharmacology, EarlyView.
Aim This study intends to assess the pharmacokinetic properties and treatment response of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria infection in Western Kenya. Methods Seventy‐five women with uncomplicated P.
Elizabeth Juma, Junjie Ding, Martin Ongas, Nelly Koskei, Kevin Onyango, Florence Oloo, Rashid Aman, Gilbert Kokwaro, Joel Tarning, Bernhards Ogutu   +9 more
wiley   +1 more source

Reproductive and Developmental Toxicity Assessment of Human Umbilical Cord Mesenchymal Stem Cells in Rats

Frontiers in Cell and Developmental Biology, 2022
Objective: Human umbilical cord mesenchymal stem cells (hUC-MSCs) have shown very attractive potential in clinical applications for the treatment of various diseases. However, the data about the reproductive and developmental toxicity of hUC-MSCs remains
Xiaobo Li, Xiaobo Li, Qijing Huang, Xiangxiang Zhang, Changfeng Xie, Muyun Liu, Yueming Yuan, Yueming Yuan, Jianjia Feng, Haoyu Xing, Li Ru, Li Ru, Zheng Yuan, Zhiyong Xu, YaoXiang Yang, Yan Long, Chengfeng Xing, Jianping Song, Jianping Song, Xiang Hu, Qin Xu, Qin Xu   +21 more
doaj   +1 more source

Access to Artemisinin-Based Anti-Malarial Treatment and its Related Factors in Rural Tanzania. [PDF]

, 2013
Artemisinin-based combination treatment (ACT) has been widely adopted as one of the main malaria control strategies. However, its promise to save thousands of lives in sub-Saharan Africa depends on how effective the use of ACT is within the routine ...
A Bhattarai, Anonymous, Anonymous, B Greenwood, BP Mmbando, D de Savigny, D Schellenberg, Dan Kajungu, Don de Savigny, DS Tarimo, E Rutta, EA Okiro, Gumi A Mrisho, H Reyburn, IM Masanja, Irene Kuepfer, Irene M Masanja, JA Schellenberg, JR Armstrong Schellenberg, JR Schellenberg, JR Schellenberg, KI Barnes, KP Paaijmans, M Otten, M Tanner, M Tanner, M Tipke, Majige Selemani, Mbaraka Amuri, MM Nyunt, Mustafa H Njozi, MW Hetzel, NC Kakwani, P Gething, P Smithson, P Tugwell, PL Alonso, PMI, R Feachem, R Khatib, Rashid A Khatib, S Abdulla, S Alba, S Alba, S McCombie, Salim M Abdulla, TR Leahy, V D'Acremont, V D’Acremont, W Deressa, W Prudhomme O’Meara, WHO   +51 more
core   +4 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Effect and mechanisms of shikonin on breast cancer cells in vitro and in vivo

BMC Complementary Medicine and Therapies
Background Breast cancer seriously affects physical and mental health of women. Despite advances in the clinical use of different treatments, breast cancer remains a major cause of mortality.
Chuyi Yu, Haoyu Xing, Xiaguo Fu, Yingying Zhang, Xiufang Yan, Jianjia Feng, Zhouqin He, Li Ru, Chunlong Huang, Jianming Liang   +9 more
doaj   +1 more source

Differentially expressed genes during contrasting growth stages of Artemisia annua for artemisinin content. [PDF]

PLoS ONE, 2013
Artemisia annua is the source of antimalarial phytomolecule, artemisinin. It is mainly produced and stored in the glandular secretory trichomes present in the leaves of the plant.
Priya Nair, Amita Misra, Alka Singh, Ashutosh K Shukla, Madan M Gupta, Anil K Gupta, Vikrant Gupta, Suman P S Khanuja, Ajit K Shasany   +8 more
doaj   +1 more source

The spread of antimalarial drug resistance: A mathematical model with practical implications for ACT drug policies [PDF]

, 2008
Most malaria-endemic countries are implementing a change in antimalarial drug policy to artemisinin combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Arjen Dondorp, Ian Hastings, Nicholas Day, Nicholas White, Shunmay Yeung, Wirichada Pongtavornpinyo   +5 more
core   +1 more source

The Jasmonate‐Responsive SmMPK3–SmWRKY33 Module Positively Regulates Tanshinone Biosynthesis in Salvia miltiorrhiza

Plant Biotechnology Journal, EarlyView.
ABSTRACT Tanshinones, the major bioactive diterpenes in Salvia miltiorrhiza Bunge, are widely used to treat cardiovascular and cerebrovascular diseases. While jasmonates (JAs) are known to modulate tanshinones accumulation, the molecular link between JA signalling and tanshinone biosynthesis remains unclear.
Renjun Qu, Shiwei Wang, Xinxin Wang, Jiaming Peng, Juan Guo, Guanghong Cui, Tong Chen, Meilan Chen, Shuangshuang Zhao, Ye Shen   +9 more
wiley   +1 more source

Simultaneous Quantitative Determination of Six Caffeoylquinic Acids in Matricaria chamomilla L. with High-Performance Liquid Chromatography

Journal of Chemistry, 2019
A simple and effective method for the simultaneous quantitative analysis of six caffeoylquinic acids (CAs) in Matricaria chamomilla L. (M. chamomilla) using high-performance liquid chromatography (HPLC) with diode-array detection (DAD) was established ...
Yifan Zhao, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Yue Bai, Dong Zhang, Lan Yang   +7 more
doaj   +1 more source

A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial. [PDF]

PLoS Medicine, 2011
Artemisinin-based combination therapies (ACTs) are the mainstay for the management of uncomplicated malaria cases. However, up-to-date data able to assist sub-Saharan African countries formulating appropriate antimalarial drug policies are scarce.Between
Four Artemisinin-Based Combinations (4ABC) Study Group
doaj   +1 more source