Results 81 to 90 of about 74,638 (327)

Fu-zi decoction attenuate rheumatoid arthritis in vivo and in vitro by modulating RANK/RANKL signaling pathway

Frontiers in Pharmacology
BackgroundFu-zi decoction (FZD) has a long history of application for treating Rheumatoid arthritis (RA) as a classic formulation. However, its underlying mechanisms have not been fully elucidated.
Zhenzhen Pan, Zhenzhen Pan, Fangchan Li, Yujie Xu, Huimin Ye, Jiahui Liu, Zhenhua Wang, Changsheng Deng, Jianping Song, Manxue Mei, Changqing Li   +10 more
doaj   +1 more source

Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda.

Journal of Infectious Diseases, 2020
BACKGROUND In Uganda artemether-lumefantrine is recommended for malaria treatment and sulfadoxine-pyrimethamine (SP) for chemoprevention during pregnancy, but drug resistance may limit efficacies.
Victor Asua, Melissa D. Conrad, O. Aydemir, Marvin Duvalsaint, J. Legac, E. Duarte, Patrick K. Tumwebaze, Deborah Chin, R. Cooper, Adoke Yeka, M. Kamya, G. Dorsey, S. Nsobya, J. Bailey, P. Rosenthal   +14 more
semanticscholar   +1 more source

A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic Leukemia

Advanced Science, EarlyView.
A self‐assembling nanotherapeutic strategy is designed—CD38‐PHD/G‐NPs, which released γ‐secretase inhibitor first, followed by adaptive dihydroartemisnin release in response to elevated reactive oxygen species levels. This controlled, sequential release strategy maximizes the synergistic anti‐leukemic efficacy of two agents with distinct mechanisms of ...
Ruinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji   +9 more
wiley   +1 more source

Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract – possible synergistic and resistance mechanisms [PDF]

Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin.
A Belkaid, A De Donno, A Nemeikaitė-Čėnienė, ABS Sidhu, Alexander P. Gorka, Alexei A. Lapkin, AR Bilia, AV Pandey, B Tepe, B Zhang, BC Elford, CW Jefford, CW Wright, D Cao, E Hsu, E Hsu, EG Yordi, F Van der Kooy, FH Jansen, G Noratto, Gabriele Pradel, Guy C. Barker, H Wagner, H Wagner, H Wagner, HJ Woerdenbag, İ Gülçin, J Golenser, J Mouton, J Suberu, J Wang, J-G Xu, John O. Suberu, K Liu, K Rath, L Cui, L Vivas, L-H Wang, Lauren Jacobs, M Friedman, M Petersen, M Willcox, M Willcox, MC Berenbaum, N Acton, N Erkan, N Klonis, Neil Sullivan, P Miketova, Paul D. Roepe, PG Bray, PJ Weathers, PJ Weina, PK Agrawal, PM De Magalhaes, PM O’Neill, PT Lansbury, QL Fivelman, R Feng, RK Haynes, RK Haynes, RT Eastman, S De Ridder, T Carbonara, TN Bennett, U Eckstein-Ludwig, W Li, XC Ding, Z Bozdech   +68 more
core   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag, Ademowo, George, Arze, Cesar, Asaq Molecular Marker Study Group, Baliraine, Frederick N, Berens-Riha, Nicole, Björkman, Anders, Borrmann, Steffen, Checchi, Francesco, Dahal, Prabin, Davis, Timothy ME, Desai, Meghna, Dhorda, Mehul, Djimdé, Abdoulaye A, Dorsey, Grant, El-Sayed, Badria B, Eshetu, Teferi, Eyase, Frederick, Falade, Catherine, Faucher, Jean-François, Fröberg, Gabrielle, Gadalla, Nahla B, Grivoyannis, Anastasia, Guérin, Philippe, Hamour, Sally, Houzé, Sandrine, Johnson, Jacob, Kamugisha, Erasmus, Kariuki, Simon, Kiechel, Jean-René, Kironde, Fred, Kofoed, Poul-Erik, LeBras, Jacques, Malmberg, Maja, Moriera, Clarissa, Mwai, Leah, Mårtensson, Andreas, Ménard, Didier, Ngasala, Billy, Nosten, Francois, Nsanzabana, Christian, Nsobya, Samuel L, Nzila, Alexis, Oguike, Mary, Ogutu, Bernhards, Otienoburu, Sabina Dahlström, Ouédraogo, Jean-Bosco, Piola, Patrice, Plowe, Christopher V, Price, Ric N, Rombo, Lars, Rosenthal, Philip J, Schramm, Birgit, Sibley, Carol Hopkins, Somé, A Fabrice, Stepniewska, Kasia, Sutherland, Colin J, Thwing, Julie, Ursing, Johan, Venkatesan, Meera, Wong, Rina PM, Zeynudin, Ahmed, Zongo, Issaka   +62 more
core   +3 more sources

Chemical stability of artemisinin derivatives [PDF]

Malaria Journal, 2012
Background Artemisinin derivatives are the most effective and fast acting antimalarials available. Several studies have demonstrated the presence of fake and bad quality antimalarials on the Asian and African market. Stability of artemisinin derivatives has so far only been partially investigated and it is unclear how much this contributes to the ...
Jacqueline Plaizier-Vercammen, Stijn Vanermen, Marc Mommaerts, Yvan Vander Heyden, Kristel Van Acker, Jolien Meskens   +5 more
openaire   +3 more sources

Electronic Nanomaterials for Plants: A Review on Current Advances and Future Prospects

Advanced Electronic Materials, EarlyView.
Global food security faces mounting challenges from climate change and rapid population growth. This review highlights the pivotal role of electronic nanomaterials–including metals, metal oxides, and carbon‐based structures–in enhancing plant photosynthesis, nutrient uptake, and stress resilience. Furthermore, it explores how emerging platforms such as
Ciro Allará, Giuseppe Ciccone, Manuela Ciocca, Sahira Vasquez, Pietro Ibba, Mauro Maver, Tanja Mimmo, Paolo Lugli, Luisa Petti   +8 more
wiley   +1 more source

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products [PDF]

, 2013
Background: Artemisinin-based fixed dose combination (FDC) products are recommended by World Health Organization (WHO) as a first-line treatment. However, the current artemisinin FDC products, such as beta-artemether and lumefantrine, are inherently ...
Bracke, Nathalie, Burvenich, Christian, D'Hondt, Matthias, De Spiegeleer, Bart, Duchateau, Luc, Peremans, Kathelijne, Vandercruyssen, Kirsten, Wega, Sultan Suleman, Wynendaele, Evelien   +8 more
core   +2 more sources

Metabolic regulation and engineering of artemisinin biosynthesis in A. annua

Medicinal Plant Biology, 2023
Artemisinin is a potent anti-malarial sesquiterpene lactone that is naturally biosynthesized in glandular trichomes of a Chinese herbal plant, Artemisia annua. Although semi-synthesis of artemisinin in yeast has been feasible, at present the A.
Yueli Tang, Lien Xiang, Fangyuan Zhang, Kexuan Tang, Zhihua Liao   +4 more
doaj   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source