Pyridoxal kinase inhibition by artemisinins down-regulates inhibitory neurotransmission
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Information processing in the central nervous system relies on chemical synapses where neurotransmitters such as the inhibitory neurotransmitter γ-aminobutyric acid (GABA) are released at presynaptic nerve endings.
V. B. Kasaragod +7 more
semanticscholar +1 more source
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. [PDF]
, 2012 BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
Khairnar, K +6 more
core +1 more source
Neurotoxicity of Artemisinin Derivatives [PDF]
Clinical Infectious Diseases, 2006 tion to a recent letter published in this journal by Toovey [ 1 ] regarding the alleged neurotoxicity of the artemisinin derivatives. The letter was in response to a reply by Newton et al. [2] to a case reported by Franco-Paredes et al. [3]. This letter makes reference to our congress presentation [4], but Toovey has changed the title of our abstract ...
Adjei, George Obeng +2 more
openaire +4 more sources
Discovery and repurposing of artemisinin
Frontiers of Medicine, 2022 Malaria is an ancient infectious disease that threatens millions of lives globally even today. The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in a paradigm shift and been recognized as the "best hope for the treatment of malaria" by World Health Organization.
Shi, Qiaoli +6 more
openaire +2 more sources
Artemisinin resistance in Plasmodium falciparum malaria. [PDF]
, 2009 BACKGROUND: Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease.
An, Sen Sam +22 more
core +1 more source
Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs [PDF]
, 2009 Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of the increasing rate that it is being used for this purpose. Attention is
A. MBAYE +22 more
core +2 more sources
Artemisinin Resistance and the Blame Game. [PDF]
Clinical Infectious Diseases, 2016 Kremsner, PG, Krishna, S, Staines, HM
core +5 more sources
Pharmacokinetic modelling of the anti-malarial drug artesunate and its active metabolite dihydroartemisinin [PDF]
, 2012 A four compartment mechanistic mathematical model is developed for the pharmacokinetics of the commonly used anti-malarial drug artesunate and its principle metabolite dihydroartemisinin following oral administration of artesunate.
Adam J. Hall +36 more
core +2 more sources
Oxidation of Erythrocytes Enhance the Production of Reactive Species in the Presence of Artemisinins
International Journal of Molecular Sciences, 2020 In red blood cells, hemoglobin iron represents the most plausible candidate to catalyze artemisinin activation but the limited reactivity of iron bound to hemoglobin does not play in favor for its direct involvement.
Ioannis Tsamesidis +3 more
semanticscholar +1 more source
Efficacy and safety of moxidectin, synriam, synriam-praziquantel versus praziquantel against schistosoma haematobium and S. mansoni infections: a randomized, exploratory phase 2 trial [PDF]
, 2016 Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical ...
Barda, Beatrice +5 more
core +3 more sources