Results 21 to 30 of about 8,416 (212)

More than anti-malarial agents: therapeutic potential of artemisinins in neurodegeneration

Neural Regeneration Research, 2019
Artemisinin, also called qinghaosu, is originally derived from the sweet wormwood plant (Artemisia annua), which is used in traditional Chinese medicine. Artemisinin and its derivatives (artemisinins) have been widely used for many years as anti-malarial
Bing-Wen Lu, Larry Baum, Kwok-Fai So, Kin Chiu, Li-Ke Xie   +4 more
doaj   +1 more source

Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites

Frontiers in Chemistry, 2020
We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA ...
Ho Ning Wong, Vivian Padín-Irizarry, Mariëtte E. van der Watt, Janette Reader, Wilna Liebenberg, Lubbe Wiesner, Peter Smith, Korina Eribez, Elizabeth A. Winzeler, Dennis E. Kyle, Lyn-Marie Birkholtz, Dina Coertzen, Richard K. Haynes   +12 more
doaj   +1 more source

A Novel 2-Carbon-Linked Dimeric Artemisinin With Potent Antileukemic Activity and Favorable Pharmacology

Frontiers in Oncology, 2022
Acute myeloid leukemia (AML) remains a devastating disease, with low cure rates despite intensive standard chemotherapy regimens. In the past decade, targeted antileukemic drugs have emerged from research efforts.
Amanda B. Kagan, Blake S. Moses, Bryan T. Mott, Ganesha Rai, Nicole M. Anders, Michelle A. Rudek, Michelle A. Rudek, Curt I. Civin   +7 more
doaj   +1 more source

Recent advances in the treatment of Malaria

Biomedical Research Journal, 2016
Malaria is an infectious disease caused by protozoan parasites belonging to the Plasmodium species. The disease has been a major cause of mortality and morbidity, especially in populations of African and SouthEast Asian countries.
Sohal Satish, Jayashree Puttur, Evans Coutinho, Premlata Ambre, Santosh R Nandan   +4 more
doaj   +1 more source

The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside

Pharmaceutics, 2021
Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose.
Liezl Gibhard, Dina Coertzen, Janette Reader, Mariëtte E. van der Watt, Lyn-Marie Birkholtz, Ho Ning Wong, Kevin T. Batty, Richard K. Haynes, Lubbe Wiesner   +8 more
doaj   +1 more source

Safety of Artemisinin Derivatives in the First Trimester of Pregnancy: A Controversial Story

Molecules, 2020
Artemisinin combination therapy (ACT) is recommended by the World Health Organization (WHO) as first line treatment for uncomplicated malaria both in adults and children.
Sarah D’Alessandro, Elena Menegola, Silvia Parapini, Donatella Taramelli, Nicoletta Basilico   +4 more
doaj   +1 more source

Recent Progresses in Cancer Nanotherapeutics Design Using Artemisinins as Free Radical Precursors

Frontiers in Chemistry, 2020
Artemisinin and its derivatives (ARTs) are sort of important antimalarials, which exhibit a wide range of biological activities including anticancer effect.
Yalan Wu, Yalan Wu, Qingping Zeng, Zhiwen Qi, Tao Deng, Fang Liu   +5 more
doaj   +1 more source

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Frontiers in Plant Science, 2022
Artemisinin is a natural bioactive sesquiterpene lactone containing an unusual endoperoxide 1, 2, 4-trioxane ring. It is derived from the herbal medicinal plant Artemisia annua and is best known for its use in treatment of malaria.
Karim Farmanpour-Kalalagh, Arman Beyraghdar Kashkooli, Alireza Babaei, Ali Rezaei, Alexander R. van der Krol   +4 more
doaj   +1 more source

Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria [PDF]

, 2008
Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have
Coulibaly, Boubacar, Klose, Christina, Kouyaté, Bocar, Mansmann, Ulrich, Meissner, Peter E., Mockenhaupt, Frank P., Müller, Olaf, Schirmer, R. Heiner, Sié, Ali, Walter-Sack, Ingeborg, Zoungrana, Augustin   +10 more
core   +1 more source

Antimalarial and antitumour activities of the steroidal quinone-methide celastrol and its combinations with artemiside, artemisone and methylene blue

Frontiers in Pharmacology, 2022
Artemisinin, isolated from the traditional Chinese medicinal plant qīng hāo 青蒿 (Artemisia annua) and its derivatives are used for treatment of malaria. With treatment failures now being recorded for the derivatives and companion drugs used in artemisinin
Jerome P. L. Ng, Yu Han, Li Jun Yang, Lyn-Marie Birkholtz, Dina Coertzen, Ho Ning Wong, Richard K. Haynes, Paolo Coghi, Vincent Kam Wai Wong   +8 more
doaj   +1 more source