Quantifying the pharmacology of antimalarial drug combination therapy. [PDF]
, 2016 Most current antimalarial drugs are combinations of an artemisinin plus a 'partner' drug from another class, and are known as artemisinin-based combination therapies (ACTs). They are the frontline drugs in treating human malaria infections.
Hodel, Eva Maria
core +1 more source
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. [PDF]
PLoS ONE, 2009 Heme (Fe2+ protoporphyrin IX) is an essential molecule that has been implicated the potent antimalarial action of artemisinin and its derivatives, although the source and nature of the heme remain controversial.
Shiming Zhang, Glenn S Gerhard
doaj +1 more source
In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative
Medicines, 2022 Artemisinin-based Combination Therapies (ACTs) are currently the frontline treatment against Plasmodium falciparum malaria, but parasite resistance to artemisinin (ART) and its derivatives, core components of ACTs, is spreading in the Mekong countries ...
Ioannis Tsamesidis +7 more
doaj +1 more source
Research advancements and evaluation of multifactor‐induced murine models for gastric cancer
Animal Models and Experimental Medicine, EarlyView.Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang +5 more
wiley +1 more source
Imported falciparum malaria among adults requiring intensive care: analysis of the literature. [PDF]
, 2014 BACKGROUND: Malaria is the most important imported tropical disease. Infection with Plasmodium falciparum is responsible for most of the morbidity and mortality.
Armstrong, Margaret +3 more
core +3 more sources
STING deficiency promotes motor recovery in mice following brachial plexus root avulsion
Animal Models and Experimental Medicine, EarlyView.STING deficiency can increase the body weight, promote motor recovery, decrease MN death, inhibit pyroptosis and neuroinflammation, increase remyelination, and reduce the atrophy of the biceps brachii in mice with BPRA. Abstract Background Brachial plexus root avulsion (BPRA), a well‐known form of peripheral nerve injury, results in motor function loss
Yu Peng +4 more
wiley +1 more source
Delayed haemolysis after artesunate therapy in a cohort of patients with severe imported malaria due to Plasmodium falciparum [PDF]
, 2016 INTRODUCTION: Delayed haemolytic anaemia is one of the more frequent events after treatment with intravenous artesunate in patients with severe malaria.
Calvo-Cano, Antonia +4 more
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Artemisinin–Second Career as Anticancer Drug?
World Journal of Traditional Chinese Medicine, 2015 Artemisinin represents a showcase example not only for the activity of medicinal herbs deriving from traditional chinese medicine, but for phytotherapy in general.
Thomas Efferth
doaj +1 more source
Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites
Molecules, 2020 The emergence of Plasmodium falciparum parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health.
Manel Ouji +6 more
doaj +1 more source
Applicability of Redirecting Artemisinins for New Targets
Global Challenges, 2023 Employing new therapeutic indications for drugs that are already approved for human use has obvious advantages, including reduced costs and timelines, because some routine steps of drug development and regulation are not required.
Jacob Golenser +6 more
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