Results 61 to 70 of about 17,496 (173)
Monitoring antimalarial drug resistance: Applying lessons learned from the past in a fast-moving present [PDF]
, 2012 The need for robust surveillance of antimalarial drugs is more urgent than it has ever been. In the western region of Cambodia, artemisinin resistance has emerged in Plasmodium falciparum and threatens to undermine the efficacy of highly effective ...
Price, Ric N., Sibley, Carol Hopkins
core +1 more source
In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives [PDF]
Antimicrobial Agents and Chemotherapy, 2008 ABSTRACT In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 μM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E ...
Spicher, M. +7 more
openaire +3 more sources
Biosynthese des Rotalgen‐Diterpens Peyssonnosol in Bakterien
Angewandte Chemie, EarlyView.Zwei Terpensynthasen aus Anaerolineae‐Bakterien katalysieren die Biosynthese von Peyssonnosen‐artigen Diterpenen aus Rotalgen. Ortsgerichtete Mutagenese ermöglichte einen partiellen Funktionswechsel, der zur Bildung zusätzlicher Nebenprodukte führte.
Zhiyong Yin +10 more
wiley +1 more source
World Antimalarial Resistance Network (WARN) III: Molecular Markers for Drug Resistant Malaria [PDF]
, 2010 Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Barnwell, John W +14 more
core +2 more sources
Interfacial Photoelectrochemistry in Organic Synthesis
Angewandte Chemie International Edition, Accepted Article.Photoelectrodes have traditionally enjoyed widespread attention as heterogeneous catalysts for the activation of water and CO2 in energy research, while photoelectrochemistry with homogeneous molecular catalysts dominates the activations of more complex molecules in organic synthesis.
Gabriel Chan +4 more
wiley +1 more source
Discovery of Artemisinin (Qinghaosu) [PDF]
Molecules, 2009 Artemisinin (Qinghaosu), a new antimalarial drug, was discovered in China in the early 1970s. The discovery of artemisinin is attributed to You-You Tu, at that time a middle-aged phytochemist working in the Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine.
openaire +3 more sources
Neurotoxic Mode of Action of Artemisinin [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT We recently described a screening system designed to detect neurotoxicity of artemisinin derivatives based on primary neuronal brain stem cell cultures (G. Schmuck and R. K. Haynes, Neurotoxicity Res. 2:37-49, 2000). Here, we probe possible mechanisms of this brain stem-specific neurodegeneration, in which artemisinin-sensitive ...
Schmuck, G. +3 more
openaire +4 more sources
Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria
Angewandte Chemie International Edition, EarlyView.Two terpene synthases derived from Anaerolineae bacteria catalyse the biosynthesis of peyssonnosene‐type diterpenes from red algae. Site‐directed mutagenesis enabled a partial functional switch, resulting in the formation of additional byproducts. The intricate cyclisation mechanisms were investigated through isotopic labelling experiments and density ...
Zhiyong Yin +10 more
wiley +1 more source
Malaria Journal, 2016 BackgroundThe potential emergence and spread of resistance to artemisinins in the Plasmodium falciparum malaria parasite constitutes a major global health threat. Hence, improving the efficacy of artemisinins and of artemisinin-based combination therapy (
Neda Moradin +9 more
semanticscholar +1 more source