Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea [PDF]
, 2023 Selam Mihreteab +15 more
openalex +1 more source
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract The study identified process development priorities toward the feasible production of five value‐added biochemicals in a sugarcane biorefinery based on achievable bioconversion performances. Multiple process scenarios using A‐molasses as feedstock were simulated in Aspen Plus® via direct microbial conversions.
Manasseh K. Sikazwe +2 more
wiley +1 more source
Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes [PDF]
, 2017 Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results.
Avery, Mitchell A. +10 more
core
Addressing the challenge of neonatal mortality.
, 2013 Reducing neonatal mortality remains a challenge with an estimated 3.0 million neonatal deaths in 2011, three-quarters of these in sub-Saharan Africa and Southern Asia.
Blencowe, H, Cousens, S
core +1 more source
Do Health Workers' Preferences Influence their Practices? Assessment of Providers' Attitude and Personal use of new Treatment Recommendations for Management of Uncomplicated Malaria, Tanzania. [PDF]
, 2012 \ud \ud Due to growing antimalarial drug resistance, Tanzania changed malaria treatment policies twice within a decade. First in 2001 chloroquine (CQ) was replaced by sulfadoxine-pyrimethamine (SP) for management of uncomplicated malaria and by late 2006,
Khatib, Rashid A +2 more
core +3 more sources
Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies
Molecules, 2010 Artemisinins have become essential antimalarial drugs for increasingly widespread drug-resistant malaria strains. Although tremendous efforts have been devoted to decipher how this class of molecules works, their exact antimalarial mechanism is still an ...
Jian Li, Bing Zhou
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based combination therapies, TACT), consisting of two partner drugs with different mechanisms of action and similar ...
Junjie Ding +24 more
wiley +1 more source
Artemisinin resistance--modelling the potential human and economic costs. [PDF]
, 2014 BACKGROUND: Artemisinin combination therapy is recommended as first-line treatment for falciparum malaria across the endemic world and is increasingly relied upon for treating vivax malaria where chloroquine is failing.
Ashley, Elizabeth +8 more
core +1 more source
Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine
Engineering, 2019 Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and ...
Jigang Wang +6 more
doaj +1 more source
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors
EMBO Molecular Medicine, 2023 The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy.
Jasmin Taubenschmid‐Stowers +21 more
doaj +1 more source