Results 61 to 70 of about 8,416 (212)
Hybrid Gold(I) NHC-Artemether Complexes to Target Falciparum Malaria Parasites
Molecules, 2020 The emergence of Plasmodium falciparum parasites, responsible for malaria disease, resistant to antiplasmodial drugs including the artemisinins, represents a major threat to public health.
Manel Ouji +6 more
doaj +1 more source
Applicability of Redirecting Artemisinins for New Targets
Global Challenges, 2023 Employing new therapeutic indications for drugs that are already approved for human use has obvious advantages, including reduced costs and timelines, because some routine steps of drug development and regulation are not required.
Jacob Golenser +6 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley +1 more source
Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies
Molecules, 2010 Artemisinins have become essential antimalarial drugs for increasingly widespread drug-resistant malaria strains. Although tremendous efforts have been devoted to decipher how this class of molecules works, their exact antimalarial mechanism is still an ...
Jian Li, Bing Zhou
doaj +1 more source
Expression in Yeast Links Field Polymorphisms in PfATP6 to in Vitro Artemisinin Resistance and Identifies New Inhibitor Classes [PDF]
, 2017 Background. The mechanism of action of artemisinins against malaria is unclear, despite their widespread use in combination therapies and the emergence of resistance. Results.
Avery, Mitchell A. +10 more
core
Addressing the challenge of neonatal mortality.
, 2013 Reducing neonatal mortality remains a challenge with an estimated 3.0 million neonatal deaths in 2011, three-quarters of these in sub-Saharan Africa and Southern Asia.
Blencowe, H, Cousens, S
core +1 more source
Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort. [PDF]
, 2014 There is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies ...
AM Dondorp +32 more
core +4 more sources
ChemistryOpen, EarlyView.Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali +4 more
wiley +1 more source
Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine
Engineering, 2019 Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and ...
Jigang Wang +6 more
doaj +1 more source
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors
EMBO Molecular Medicine, 2023 The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy.
Jasmin Taubenschmid‐Stowers +21 more
doaj +1 more source