The S2 Pocket Governs the Genus‐Specific Substrate Selectivity of Coronavirus 3C‐Like Protease
Advanced Science, Volume 11, Issue 44, November 26, 2024.This study reveals the critical role of the S2 pocket in coronavirus 3C‐like protease (CoV 3CLpro) for substrate selectivity and its variability across CoV genera. Analysis of ancestral and modern 3CLpros sheds light on evolutionary processes and their effect on the efficacy of PF‐07321332.
Junwei Zhou +11 more
wiley +1 more source
Unusual severe cases of type 1 porcine reproductive and respiratory syndrome virus (PRRSV) infection in conventionally reared pigs in South Korea [PDF]
, 2015 BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) causes a loss of approximately US$ 70 million every year to the South Korean pork industry. There are two distinct genotypes: European (type 1) and North American (type 2).
Daesub Song +5 more
core +1 more source
, 2014 Deoxynivalenol (DON) is a mycotoxin produced by Fusarium spp. Among monogastric farm animals, swine are the most susceptible to DON as it markedly reduces feed intake and decreases weight gain.
Chorfi, Younès +5 more
core +1 more source
Replication characteristics of porcine reproductive and respiratory syndrome virus (PRRSV) European subtype 1 (Lelystad) and subtype 3 (Lena) strains in nasal mucosa and cells of the monocytic lineage: indications for the use of new receptors of PRRSV (Lena) [PDF]
, 2013 Recently, it has been demonstrated that subtype 3 strains of European type porcine reproductive and respiratory syndrome virus (PRRSV) are more virulent/pathogenic than subtype 1 strains. This points to differences in the pathogenesis.
Cao, Jun +3 more
core +2 more sources
Oligonucleotide compound and method for treating nidovirus infections [PDF]
, 2014 A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25
Bestwick, Richard K. +5 more
core
Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine [PDF]
, 2009 Background Porcine reproductive and respiratory syndrome virus (PRRSV) causes a prolonged, economically devastating infection in pigs, and immune resistance to infection appears variable. Since the porcine adaptive immune system is not fully competent at
Kelly L Klinge +4 more
core +1 more source
Haematological and pathological findings of pigs experimentally inoculated with a Chilean isolate of porcine reproductive and respiratory syndrome virus [PDF]
, 2006 The aims of this study were to characterize the haematological and bone marrow changes, gross and microscopic lesions of pigs experimentally inoculated with the Chilean isolate of porcine reproductive and respiratory syndrome virus.
Carrasco Otero, Librado +5 more
core
Open Veterinary JournalThe porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) belonging to the Arteriviridae family is the cause of PRRS disease. After being discovered for the first time in the United States in 1987, this illness quickly expanded to Canada ...
Rimayanti Rimayanti +15 more
doaj +1 more source
Virus discovery in small mammals : a closer look at the families arteriviridae and paramyxoviridae
, 2022 Virus discovery is a specific branch of virological research that is focused on the discovery and characterization of new viruses. Since the first descriptions of viruses at the end of the 19th century, the number of known viruses has grown continually, with the speed at which new viruses are being found increasing at an ever-fastening pace ...
openaire +2 more sources
Induction of ROS generation and NF-κB activation in MARC-145 cells by a novel porcine reproductive and respiratory syndrome virus in Southwest of China isolate [PDF]
, 2015 Each ORF gene nucleotide sequence of YN ...
Aiguo Xin +8 more
core +4 more sources