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Advances in the study of gut microecology and mechanisms of hyperuricemia and gouty arthritis [PDF]
Frontiers in ImmunologyGouty arthritis is a metabolic disorder caused by purine metabolism dysregulation, characterized by monosodium urate crystal deposition in and around joints, triggering acute articular inflammation via NLRP3 inflammasome activation and IL-1β-mediated ...
Youliang Zhang +15 more
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Qu-zhuo-tong-bi decoction exerts gouty arthritis therapy by skewing macrophage polarization through butanoate metabolism [PDF]
Chinese MedicineBackground Qu-zhuo-tong-bi decoction (QZTBD), a traditional Chinese medicine (TCM), has demonstrated efficacy in the treatment of gouty arthritis. However, to date, the precise pharmacological mechanisms remain unclear.
Siyue Song +8 more
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Nature CommunicationsGouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 expressed on nociceptive sensory neurons to drive gout pain and inflammation.
Chengyu Yin, Boyu Liu, Hailong An
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AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis [PDF]
Frontiers in PharmacologyBackgroundGout, a prevalent and severe form of arthritis precipitated by hyperuricemia, has been the subject of extensive research. However, the intricate underlying mechanisms governing gout-related inflammation are still only partially elucidated ...
Sijing Liu +12 more
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Older age and diclofenac are associated with increased risk of upper gastrointestinal bleeding in gout patients [PDF]
PeerJ, 2021 Background Gouty arthritis is a disease of global burden in which defective metabolism of uric acid causes arthritis. Gouty arthritis or medications used for its treatment may lead to uric acid-associated complications such as upper gastrointestinal ...
Wan Syamimee Wan Ghazali +4 more
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Vertebrae Destruction with Cauda Equina Syndrome Secondary to Spinal Gouty Arthritis: A Case Report [PDF]
Malaysian Orthopaedic Journal, 2020 Gouty arthritis commonly affects peripheral joints and is associated with hyperuricaemia. Spinal manifestations of gouty arthritis are not common, and majority of published articles worldwide were case reports.
Thuraikumar K, Wan KL, Ong KL, Lim SW
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Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis
Journal of Innate Immunity, 2023 PR domain-containing 1 with zinc finger domain (PRDM1) has been reported as a promoter of inflammation, which is a critical process involved in the pathogenesis of acute gouty arthritis.
Qingsong Zhao +6 more
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Frontiers in Pharmacology, 2022 Lagotis brachystachya Maxim, a common herb in Tibetan medicine, is mainly used to treat pneumonia, hepatitis, yellow water disease (gouty arthritis). Since long-term heavy drinking is also a risk factor for gouty arthritis, the present study aimed to ...
Min-Xia Guo +7 more
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Frontiers in Endocrinology, 2023 Neutrophil extracellular traps (NETs) are composed of chromatin filaments coated with granular and cytosolic proteins, which contribute to the pathogenesis and progression of immune-related diseases.
Shanshan Huang +5 more
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Phospholipase A2 regulates autophagy in gouty arthritis: proteomic and metabolomic studies
Journal of Translational Medicine, 2023 Background Acute gouty arthritis is inflammatory joint arthritis. Gouty arthritis (GA) involves multiple pathological processes. Deposition of joints by monosodium urate (MSU) crystals has been shown to play a critical role in the injury process.
Weili Fu, Minghao Ge, Jian Li
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