Results 71 to 80 of about 447,945 (376)

Controlled Release of Human Dental Pulp Stem Cell‐Derived Exosomes from Hydrogels Attenuates Temporomandibular Joint Osteoarthritis

Advanced Healthcare Materials, EarlyView.
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia, Yajing Tian, Yunzhe Guo, Jiaying Li, Shengjie Cui, Cécile A. Dreiss, Eileen Gentleman, Xuedong Wang   +7 more
wiley   +1 more source

24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats [PDF]

, 2016
Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25 (OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25 (OH)2D3] accumulates in articular cartilage following injection of [3 H]-25(OH ...
Boyan, Barbara D., Coutts, Richard D., Healey, Robert, Hyzy, Sharon L., Pan, Qingfen, Schwartz, Zvi, Scott, Kayla M.   +6 more
core   +7 more sources

Rapid Deep Vat Printing Using Photoclickable Collagen‐Based Bioresins

Advanced Healthcare Materials, EarlyView.
Collagen‐based resin formulations based on thiol‐ene photoclick chemistry are demonstrated. These resins enable easy handleability under neutral conditions and further allow facile fabrication of multicellular tissue constructs via tomographic or FLight printing.
Michael Winkelbauer, Amelia Hasenauer, Dominic Rütsche, Hao Liu, Jakub Janiak, Michael Nguyen, Karen L. Christman, Marcy Zenobi‐Wong, Parth Chansoria   +8 more
wiley   +1 more source

In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

Scientific Reports, 2016
The in vivo measurement of articular cartilage deformation is essential to understand how mechanical forces distribute throughout the healthy tissue and change over time in the pathologic joint.
D. Chan, L. Cai, Kent D. Butz, S. Trippel, E. Nauman, C. Neu   +5 more
semanticscholar   +1 more source

Tensorial Electrokinetics in Articular Cartilage [PDF]

Biophysical Journal, 2006
Electrokinetic phenomena contribute to biomechanical functions of articular cartilage and underlie promising methods for early detection of osteoarthritic lesions. Although some transport properties, such as hydraulic permeability, are known to become anisotropic with compression, the direction-dependence of cartilage electrokinetic properties remains ...
Thomas M. Quinn, Boris Reynaud
openaire   +3 more sources

Structural Motifs in Soft Fibrous Tissues: Revealing Structure‐Mechanics Relationships in Deformation and Tear Resistance for Biomimetic Material Design

Advanced Healthcare Materials, EarlyView.
This review explores how soft fibrous tissues achieve their remarkable mechanical behavior through recurring structural motifs across multiple length scales. It highlights key advances in mimicking these features using fiber‐reinforced hydrogels and hierarchical composites, offering insights into mechanical compatibility, flaw tolerance, and tear ...
Mirit Sharabi
wiley   +1 more source

Effects of radiopharmaceuticals on articular cartilage’s mechanical properties

Nukleonika, 2019
As radiation science and technology advances, nuclear medicine applications are increasing worldwide which necessitate the understanding of biological implications of such practices.
Kuzu Nihal, Cicek Ekrem
doaj   +1 more source

Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis

Orthopaedic Journal of Sports Medicine, 2017
Background: Osteoarthritis (OA) currently affects 10% of the American population. There has been a recent push to determine exactly what causes OA and how it can be treated most effectively.
Rachel Garfinkel, Matthew F. Dilisio, D. Agrawal   +2 more
semanticscholar   +1 more source

Nutrition and degeneration of articular cartilage [PDF]

Knee Surgery, Sports Traumatology, Arthroscopy, 2012
AbstractPurposeTo determine the importance of synovial fluid (SF) or subchondral bone marrow (BM) as nutrition sources in cartilage degeneration.MethodsNinety‐five‐month‐old male rabbits were randomly divided into 5 groups according to sources of nutrition: SFBM‐both; BM‐only; SF‐only; None‐SFBM; and Free plug (unrestricted). Nutrition to 4‐mm‐diameter
Yuze Wang, Dongdong He, Lei Wei, Lei Wei, Lingyuan Zeng, Xiaochun Wei   +5 more
openaire   +3 more sources

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source