Correlation of Patient Symptoms With Labral and Articular Cartilage Damage in Femoroacetabular Impingement. [PDF]
Orthop J Sports Med, 2018 BackgroundFemoroacetabular impingement (FAI) can lead to labral and articular cartilage injuries as well as early osteoarthritis of the hip. Currently, the association of patient symptoms with the progression of labral and articular cartilage injuries ...
Grace T +5 more
europepmc +4 more sources
Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis. [PDF]
JCI Insight, 2020 Rheumatoid arthritis (RA) is characterized by synovial joint inflammation, cartilage damage, and dysregulation of the adaptive immune system. While neutrophil extracellular traps (NETs) have been proposed to play a role in the generation of modified autoantigens and in the activation of synovial fibroblasts, it remains unknown whether NETs are directly
Carmona-Rivera C +9 more
europepmc +5 more sources
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats [PDF]
PLoS ONE, 2016 Osteoarthritis (OA) in humans is associated with low circulating 25-hydroxyvitamin D3 [25 (OH)D3]. In vitamin D replete rats, radiolabeled 24R,25-dihydroxyvitamin D3 [24R,25 (OH)2D3] accumulates in articular cartilage following injection of [3 H]-25(OH ...
Boyan, Barbara D. +6 more
core +10 more sources
Intra-Articular Injections of Curcumin Monoglucuronide TBP1901 Suppresses Articular Cartilage Damage and Regulates Subchondral Bone Alteration in an Osteoarthritis Rat Model. [PDF]
Cartilage, 2021 Objective Curcumin monoglucuronide (TBP1901) is highly water soluble and can convert to free form curcumin, which has pharmacological effects, on intravenous administration.
Nakahata A +8 more
europepmc +2 more sources
Blockade of TRPM7 Alleviates Chondrocyte Apoptosis and Articular Cartilage Damage in the Adjuvant Arthritis Rat Model Through Regulation of the Indian Hedgehog Signaling Pathway. [PDF]
Front Pharmacol, 2021 Articular cartilage damage with subsequent impairment of joint function is a common feature of articular diseases, in particular, rheumatoid arthritis and osteoarthritis. While articular cartilage injury mediated by chondrocyte apoptosis is a known major
Ma G +6 more
europepmc +2 more sources
Oxidative DNA damage in osteoarthritic porcine articular cartilage [PDF]
Journal of Cellular Physiology, 2008 AbstractOsteoarthritis (OA) is associated with increased levels of reactive oxygen species. This study investigated if increased oxidative DNA damage accumulates in OA articular cartilage compared with non‐OA articular cartilage from pigs with spontaneous OA.
Antonia F. Chen +3 more
openalex +3 more sources
Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis [PDF]
Scientific Reports, 2017 Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known. In this study, we found a unique inverse correlation between Wnt7a gene expression and that of
Averi L. Gibson +5 more
openalex +2 more sources
Study on the damage mechanism of articular cartilage based on the fluid–solid coupled particle model [PDF]
Advances in Mechanical Engineering, 2015 Articular cartilage damage is the primary cause of osteoarthritis. Very little literature work focuses on the microstructural damage mechanism of articular cartilage.
Jun Hong, T Matthew Evans, Peter L Mente
doaj +2 more sources
What Is the Association Between Articular Cartilage Damage and Subsequent THA 20 Years After Hip Arthroscopy for Labral Tears? [PDF]
Clin Orthop Relat Res, 2019 Background Few studies have examined long-term outcomes for patients after arthroscopic treatment for intraarticular hip conditions, and none have done so beyond 10 years postarthroscopy.
Dwyer MK +4 more
europepmc +2 more sources
Chondrocyte outgrowth into a gelatin scaffold in a single impact load model of damage/repair – effect of BMP-2 [PDF]
BMC Musculoskeletal Disorders, 2007 Background Articular cartilage has little capacity for repair in vivo, however, a small number of studies have shown that, in vitro, a damage/repair response can be induced.
Vincent Thea, Henson Frances MD
doaj +3 more sources