Artificial cells with all-aqueous droplet-in-droplet structures for spatially separated transcription and translation. [PDF]
Nat CommunTomohara K, Minagawa Y, Noji H.
europepmc +1 more source
Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine
Advanced Healthcare Materials, EarlyView.We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman +7 more
wiley +1 more source
The Potential of Artificial Cells Functioning under <i>In Situ</i> Deep-Sea Conditions. [PDF]
ACS Synth BiolKuruma Y +4 more
europepmc +1 more source
Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment
Advanced Healthcare Materials, EarlyView.Chitosan‐coated melatonin nanoemulsions (MN) recovered from a sounding rocket mission preserve droplet size and controlled‐release behavior, whereas uncoated nanoemulsions show ageing‐driven droplet growth and increased accessible drug fraction. Simple polymer coatings thus enhance the flight resilience of liquid space medicines under cumulative launch
Modupe Adebowale +4 more
wiley +1 more source
Construction of the reduced nicotinamide adenine dinucleotide salvage pathway in artificial cells and its application in amino acid synthesis. [PDF]
Chem SciLiu Y +8 more
europepmc +1 more source
Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment
Advanced Healthcare Materials, EarlyView.Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley +1 more source
Spatiotemporal Control Over Protein Release from Artificial Cells via a Light-Activatable Protease. [PDF]
Adv Biol (Weinh)Hazegh Nikroo A +4 more
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Biocompatible hydrogels with covalently embedded near‐infrared phosphorescent probes enable local tissue pO2 quantification by means of Cherenkov‐excited luminescence imaging (CELI), where optical excitation occurs within tissues upon irradiation with high‐energy electron beams.
Simin Belali +7 more
wiley +1 more source
Temporally controlled multistep division of DNA droplets for dynamic artificial cells. [PDF]
Nat CommunMaruyama T, Gong J, Takinoue M.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.A porous parylene‐coated electrode loaded with dexamethasone was developed to reduce inflammation after cochlear implantation. In guinea pigs, the device provided sustained drug release, maintained biocompatibility, improved auditory brainstem response thresholds, and reduced inflammatory cell infiltration and TNF‐α expression.
Chi‐Chieh Chang +11 more
wiley +1 more source