Results 41 to 50 of about 64,701 (260)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Hydrogel‐Based Artificial Muscles: Overview and Recent Progress

Advanced Intelligent Systems, 2020
Artificial muscles are promising as an intelligent material that can replace conventional power systems to reproduce the motion of a living organism.
Nuri Park, Jaeyun Kim
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pneumatic Artificial Muscles Based on Biomechanical Characteristics of Human Muscles

Applied Bionics and Biomechanics, 2006
This article reports the pneumatic artificial muscles based on biomechanical characteristics of human muscles. A wearable device and a rehabilitation robot that assist a human muscle should have characteristics similar to those of human muscle.
N. Saga, J. Nagase, T. Saikawa
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chemomechanical Polymers as Sensors and Actuators for Biological and Medicinal Applications

Sensors, 2007
Changes in the chemical environment can trigger large motions in chemomechanical polymers. The unique feature of such intelligent materials, mostly in the form of hydrogels, is therefore, that they serve as sensors and actuators at the same time, and do ...
Robert M. Strongin, Kazuaki Kato, Hans-Jörg Schneider   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Temperature-triggered inflatable hydrogel muscles with snap-through instability for untethered robots

Nature Communications
Pneumatic artificial muscles have been widely used in the field of robotics because of their large output force and fast actuation, however, the accompanying bulky compressors and pumps limit their miniaturized applications.
Yande Cui, Jianhua Hu, Ziyang Dong, Bing Li, Chunyu Chang   +4 more
doaj   +1 more source

Advanced Artificial Muscle for Flexible Material‐Based Reconfigurable Soft Robots

Advanced Science, 2019
Flexible material‐based soft robots are widely used in various areas. In many situations, the suitable soft robots should be rapidly fabricated to complete the urgent tasks (such as rescue), so the facile fabricating methods of the multifunctional soft ...
Zhongdong Jiao, Chao Zhang, Wei Wang, Min Pan, Huayong Yang, Jun Zou   +5 more
doaj   +1 more source

Biohybrid control of general linear systems using the adaptive filter model of cerebellum

Frontiers in Neurorobotics, 2015
The adaptive filter model of the cerebellar microcircuit has been successfully applied to biological motor control problems such as the vestibulo-ocular reflex (VOR) and to sensory processing problems such as the adaptive cancellation of reafferent noise.
Emma D. Wilson, Tareq eAssaf, Martin J. Pearson, Jonathan M. Rossiter, Paul eDean, Sean R. Anderson, John ePorrill   +6 more
doaj   +1 more source