Results 41 to 50 of about 20,267,676 (272)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Potential field based navigation for planetary rovers using internal states [PDF]

, 2008
The work in this paper aims to introduce analysis and applications for the internal state model which is a new model for a swarm of rovers interacting via pair-wise attractive and repulsive potentials.
Abdel Wahid, Mohamed Hussien Mabrouk, McInnes, C.R.   +1 more
core   +2 more sources

Research on Path Planning Algorithm for Driverless Vehicles

Mathematics, 2022
In a complex environment, although the artificial potential field (APF) method of improving the repulsion function solves the defect of local minimum, the planned path has an oscillation phenomenon which cannot meet the vehicle motion.
Hao Ma, Wenhui Pei, Qi Zhang
doaj   +1 more source

A New Method for Robot Path Planning Based Artificial Potential Field

, 2016
The artificial potential field method is used in mobile robot path planning extensively because of its simpleness, high efficiency and smooth path, but it also has its disadvantages.
Yang, Xing, Huijuan Zhang, Xing Yang, Chang, Hao, Shuangchi Zhang, Zhang, Huijuan, Chen, Chin-Yin, Hao Chang, Yang, X, Yang, Wei, Wei Yang, Zhang, Shuangchi, Chin-Yin Chen   +12 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Three-dimensional formation flying using bifurcating potential fields [PDF]

, 2009
This paper describes the design of a three-dimensional formation flying guidance and control algorithm for a swarm of autonomous Unmanned Aerial Vehicles (UAVs), using the new approach of bifurcating artificial potential fields.
Uchiyama, Kenji, Bennet, Derek J., Suzuki, Masayuki, McInnes, Colin R.   +3 more
core   +3 more sources

A Pre-Grasping Motion Planning Method Based on Improved Artificial Potential Field for Continuum Robots

Sensors, 2023
Secure and reliable active debris removal methods are crucial for maintaining the stability of the space environment. Continuum robots, with their hyper-redundant degrees of freedom, offer the ability to capture targets of varying sizes and shapes ...
Lihua Wang, Zezhou Sun, Yaobing Wang, Jie Wang, Zhijun Zhao, Chengxu Yang, Chuliang Yan   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source