Results 31 to 40 of about 1,559,905 (290)

Diversifying Selection Between Pure-Breed and Free-Breeding Dogs Inferred from Genome-Wide SNP Analysis

G3: Genes, Genomes, Genetics, 2016
Domesticated species are often composed of distinct populations differing in the character and strength of artificial and natural selection pressures, providing a valuable model to study adaptation.
Małgorzata Pilot, Tadeusz Malewski, Andre E. Moura, Tomasz Grzybowski, Kamil Oleński, Stanisław Kamiński, Fernanda Ruiz Fadel, Abdulaziz N. Alagaili, Osama B. Mohammed, Wiesław Bogdanowicz   +9 more
doaj   +1 more source

A Novel Model of Working Set Selection for SMO Decomposition Methods

, 2007
In the process of training Support Vector Machines (SVMs) by decomposition methods, working set selection is an important technique, and some exciting schemes were employed into this field.
Bao, Forrest Sheng, Sun, Shunyi Zhang Yanfei, Wang, Yuxuan, Yuan, Lei, Zhao, Zhendong   +4 more
core   +1 more source

Technologically modified genes in natural populations [PDF]

, 1993
Current theories of evolutionary and ecological genetics cannot be used for general statements on risk assessment of gene technology. In a simplifying model, the genes which are transferred from artificial populations are treated like mutations in the ...
Gabriel, Wilfried, Wöhrmann, Klaus
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Computational and Biological Analogies for Understanding Fine-Tuned Parameters in Physics

, 2010
In this philosophical paper, we explore computational and biological analogies to address the fine-tuning problem in cosmology. We first clarify what it means for physical constants or initial conditions to be fine-tuned. We review important distinctions
B. Carr, C. Duve De, Clément Vidal, D. E. Leary, D. R. Hofstadter, E. J. Chaisson, E. J. Chaisson, E. Laszlo, G. F. R. Ellis, G. F. R. Ellis, G. J. Chaitin, G. J. Chaitin, G.J. Chaitin, I. Fry, I. L. Rozental, J. D. Barrow, J. D. Barrow, J. D. Barrow, J. Gribbin, J. N. Gardner, J. N. Gardner, K. J. Holyoak, L. Smolin, L. Smolin, L. Susskind, M. Hesse, M. Minsky, M. Rees, M. Tegmark, N. Bostrom, N. Rescher, P. C. W. Davies, P. C. W. Davies, P. C. W. Davies, P. C. W. Davies, S. B. Carroll, S. Lloyd, S. Wolfram, V. J. Stenger, V. J. Stenger   +39 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Review: Balancing Selection for Deleterious Alleles in Livestock

Frontiers in Genetics, 2021
Harmful alleles can be under balancing selection due to an interplay of artificial selection for the variant in heterozygotes and purifying selection against the variant in homozygotes.
Martijn F. L. Derks, Martijn F. L. Derks, Marije Steensma   +2 more
doaj   +1 more source

Opportunistic use of a wool-like artificial material as lining of Tit (Paridae) nests [PDF]

, 2012
The lining material is a key element of bird nests primarily serving as insulation for the adult, eggs and/or chicks but collection of such material will have an energetic cost.
Deeming, D. Charles, du Feu, Christopher R., Surgey, Joanne   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Improvement of the Uranium Sequestration Ability of a Chlamydomonas sp. (ChlSP Strain) Isolated From Extreme Uranium Mine Tailings Through Selection for Potential Bioremediation Application

Frontiers in Microbiology, 2018
The extraction and processing of uranium (U) have polluted large areas worldwide, rendering anthropogenic extreme environments inhospitable to most species.
Beatriz Baselga-Cervera, Julia Romero-López, Camino García-Balboa, Eduardo Costas, Victoria López-Rodas   +4 more
doaj   +1 more source