Results 41 to 50 of about 1,559,905 (290)

Should we feed wildlife? A call for further research into this recreational activity

open access: yesConservation Science and Practice, 2023
Independent human–wildlife feeding interactions (i.e., the feeding of wildlife by the public outside of organized ecotourism activities) represent an increasingly common way in which humans and wildlife are engaging with one another.
Laura L. Griffin, Simone Ciuti
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The power of natural selection [PDF]

open access: yes, 2002
In a recent paper, Steven Horst argued that if traditional physicalist accounts of consciousness cannot explain why there are conscious phenomena in the world then teleological accounts of consciousness that appeal to the notion of natural selection ...
Macpherson, F.
core  

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Fisheries‐induced evolution of alternative male life history tactics in Coho salmon

open access: yesEvolutionary Applications, 2020
Fisheries‐induced evolution (FIE) can result when harvest imposes artificial selection on variation in heritable phenotypic traits. While there is evidence for FIE, it remains difficult to disentangle the contributions of within‐generation demographic ...
Kyle A. Young   +2 more
doaj   +1 more source

Integration of navigation and action selection functionalities in a computational model of cortico-basal ganglia-thalamo-cortical loops [PDF]

open access: yes, 2005
This article describes a biomimetic control architecture affording an animat both action selection and navigation functionalities. It satisfies the survival constraint of an artificial metabolism and supports several complementary navigation strategies ...
Berthoz, Alain   +4 more
core   +4 more sources

Artificial selection for food colour preferences [PDF]

open access: yesProceedings of the Royal Society B: Biological Sciences, 2015
Colour is an important factor in food detection and acquisition by animals using visually based foraging. Colour can be used to identify the suitability of a food source or improve the efficiency of food detection, and can even be linked to mate choice. Food colour preferences are known to exist, but whether these preferences are heritable
Cole, Gemma L, Endler, John A
openaire   +4 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A computational model of evolution: haploidy versus diploidy [PDF]

open access: yes, 1999
In this paper, the study of diploidy is introduced like and important mechanism for memory reinforcement in artificial environments where adaptation is very important.
Berlanga de Jesús, Antonio   +3 more
core   +1 more source

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