Results 61 to 70 of about 4,966,594 (348)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Pareto Optimization for Subset Selection with Dynamic Cost Constraints
, 2019 In this paper, we consider the subset selection problem for function f with constraint bound B which changes over time. We point out that adaptive variants of greedy approaches commonly used in the area of submodular optimization are not able to maintain
Neumann, A. +7 more
core +1 more source
Darwin, artificial selection, and poverty [PDF]
, 2016 This paper argues that the processes of evolutionary selection are becoming increasingly artificial, a trend that goes against the belief in a purely natural selection process claimed by Darwin's natural selection theory.
Sanchez, Luis
core +2 more sources
Frontiers in Microbiology, 2018 The extraction and processing of uranium (U) have polluted large areas worldwide, rendering anthropogenic extreme environments inhospitable to most species.
Beatriz Baselga-Cervera +4 more
doaj +1 more source
Should we feed wildlife? A call for further research into this recreational activity
Conservation Science and Practice, 2023 Independent human–wildlife feeding interactions (i.e., the feeding of wildlife by the public outside of organized ecotourism activities) represent an increasingly common way in which humans and wildlife are engaging with one another.
Laura L. Griffin, Simone Ciuti
doaj +1 more source
Artificial selection for improved energy efficiency is reaching its limits in broiler chickens
Scientific Reports, 2018 Modern broiler chickens are a major animal husbandry success story, both in terms of efficient resource utilisation and environmental sustainability. However, continuing artificial selection for both efficiency and rapid growth will be subject to both ...
C. W. Tallentire +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Artificial Immune Systems: A Novel Approach to Pattern Recognition [PDF]
, 2002 This chapter introduces a new computational intelligence paradigm to perform pattern recognition, named Artificial Immune Systems (AIS). AIS take inspiration from the immune system in order to build novel computational tools to solve problems in a vast ...
Timmis, Jon, de Castro, Leandro N.
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Comparative whole-genome analysis reveals artificial selection effects on Ustilago esculenta genome
DNA Research, 2017 Ustilago esculenta, infects Zizania latifolia, and induced host stem swollen to be a popular vegetable called Jiaobai in China. It is the long-standing artificial selection that maximizes the occurrence of favourable Jiaobai, and thus maintaining the ...
Z. Ye +7 more
semanticscholar +1 more source