Results 71 to 80 of about 1,559,905 (290)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Genomic signatures of selection in Brangus cattle revealing the genetic foundations of adaptability and production traits using a breed of origin approach

open access: yesFrontiers in Animal Science
IntroductionThe composite breed Brangus combines the resilience and adaptability of the Bos t. indicus breed Brahman with the superior meat quality and fertility traits of the Bos t. taurus breed Angus.
Gabriel A. Zayas, Raluca G. Mateescu
doaj   +1 more source

Interactions between Behaviour and Genetics in Wild and Domestic Bird Populations [PDF]

open access: yes
Personality traits can be favoured by both natural and artificial selection, if they result in increased fitness or productivity, and therefore play an important role in both wild and domestic populations.
Oers, K., van, Rodenburg, T.B.
core   +1 more source

Inbreeding in artificial selection programmes

open access: yesGenetics Research, 1961
In a population under artificial selection, the effective population size may be less than the actual number of parents selected because there will be variation between families in the character under selection and consequently in the probability of selection.
openaire   +3 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

The Effect of Continuous Selection in KiwiCross® Composite Breed on Breed Ancestry and Productivity Performance

open access: yesAnimals
Composite crosses result from the mating of two or more distinct cattle breeds. Breeding performance may improve rapidly using a well-organized composite breeding system and a clear selection index.
Mohd Jaafar   +2 more
doaj   +1 more source

The Survival of Market Orientation through Artificial Selection

open access: yesAnnals of Business Administrative Science, 2016
Observations of a Japanese automobile dealer company shifting from a selling orientation to a market orientation revealed the following: (1) A market-oriented program with a process and team orientation threatened the self-concept of the sales force and ...
Ryusuke KOSUGE, Nobuo TAKAHASHI
doaj   +1 more source

Variation of seed characteristic from natural and artificial selection in the genus Papaver [PDF]

open access: yes, 2015
Papaveraceae is a mediterranean plant family with an important scientific, commercial and ethnobotanical interest. Includes wild species, which are distributed throughout the Spanish territory, as Papaver rhoeas, P. dubium, P. bracteatum, P. hybridum and
Martín-Clemente, Elena   +1 more
core  

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