Results 51 to 60 of about 1,559,905 (290)

ASlib: A Benchmark Library for Algorithm Selection

, 2016
The task of algorithm selection involves choosing an algorithm from a set of algorithms on a per-instance basis in order to exploit the varying performance of algorithms over a set of instances.
Bischl, Bernd, Frechette, Alexandre, Hoos, Holger, Hutter, Frank, Kerschke, Pascal, Kotthoff, Lars, Leyton-Brown, Kevin, Lindauer, Marius, Malitsky, Yuri, Tierney, Kevin, Vanschoren, Joaquin   +10 more
core   +2 more sources

Selection strategies for randomly partitioned genetic replicators [PDF]

, 2019
The amplification cycle of many replicators (natural or artificial) involves the usage of a host compartment, inside of which the replicator express phenotypic compounds necessary to carry out its genetic replication.
Rondelez, Yannick, Zadorin, Anton S.
core   +4 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]

, 2006
Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H., Bloom, Jesse D., Endelman, Jeffrey B., Hiraga, Kaori, Landwehr, Marco, Otey, Christopher R.   +5 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Exploration of gene presence/absence variations in Oncorhynchus mykiss and their differentiation between wild and selection populations

Open Biology
Gene presence/absence variations (PAVs) have been considered as the important determinants of genome evolution and phenotypic diversity. However, studies on gene PAVs have been poorly documented, especially in fishes. In the present study, the pan-genome
Hancheng Bao, Na Xue, Boyuan Wang, Han Yu, Ming Huang, Jinghong He, Shuanglin Dong, Yangen Zhou, Qinfeng Gao, Yuan Tian   +9 more
doaj   +1 more source

Model worms: knowledge gains and risks associated with the use of model species in parasitological research

Parasitology, 2023
Model parasite species, whose entire life cycle can be completed in the laboratory and maintained for multiple generations, have played a fundamental role in our understanding of host–parasite interactions. Yet, keeping parasites in laboratory conditions
Robert Poulin
doaj   +1 more source

Selection of radio pulsar candidates using artificial neural networks

, 2010
Radio pulsar surveys are producing many more pulsar candidates than can be inspected by human experts in a practical length of time. Here we present a technique to automatically identify credible pulsar candidates from pulsar surveys using an artificial ...
A. G. Lyne, A. Noutsos, B. W. Stappers, Belokurov, Bishop, Cordes, Eatough, Faulkner, Firth, Hewish, Jenet, Keith, Kohonen, Lintott, Lorimer, M. J. Keith, M. Kramer, Manchester, N. Molkenthin, R. P. Eatough, Smits, Smits, Storrie-Lombardi, Van Leeuwen, Zhang   +24 more
core   +1 more source

Artificial selection of simulated microbial ecosystems [PDF]

Proceedings of the National Academy of Sciences, 2007
Recent work with microbial communities has demonstrated an adaptive response to artificial selection at the level of the ecosystem. The reasons for this response and the level at which adaptation occurs are unclear: does selection act implicitly on traits of individual species, or are higher-level traits genuinely being selected?
Williams, Hywel T. P., Lenton, Timothy M.   +1 more
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source