Results 51 to 60 of about 1,983,941 (246)

A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth

Journal of Experimental & Clinical Cancer Research, 2012
Background Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with gastric carcinogenesis. 3,3'-Diindolylmethane (DIM) is a relatively non-toxic selective AhR modulator.
Yin Xiao-Fei, Chen Jie, Mao Wei, Wang Yu-Hong, Chen Min-Hu   +4 more
doaj   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

The Aryl Hydrocarbon Receptor in Chronic Kidney Disease: Friend or Foe?

Frontiers in Cell and Developmental Biology, 2020
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes cell responses to small molecules derived from the diet, microorganisms, metabolism and pollutants.
Yenan Mo, Yenan Mo, Zhaoyu Lu, Zhaoyu Lu, Lixin Wang, Chunlan Ji, Chunlan Ji, Chuan Zou, Xusheng Liu   +8 more
doaj   +1 more source

AhR (Aryl Hydrocarbon Receptor) Polymorphisms: A Possible Role in TCDD (Dioxins)-AhR Binding and Carcinogenesis

, 2014
Carcinogenicity of dioxins seems to be largely mediated by their binding to the aryl hydrocarbon receptor (AhR), a cytosolic transcriptional regulator of cell growth, differentiation, and migration.
Ruggero Ridolfi, Floriana Boscaino, Luca Malorni, Giuseppe Palmieri, Antonio Malorni, Sergio Canzanella, Livia Malorni, Rosaria Cozzolino   +7 more
core   +1 more source

TCDD-Induced Activation of Aryl Hydrocarbon Receptor Inhibits Th17 Polarization and Regulates Non-Eosinophilic Airway Inflammation in Asthma.

PLoS ONE, 2016
The aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family, has recently been demonstrated to regulate T cell differentiation. Whether AhR activation participates in allergic airway inflammation remains unknown.
Xiao-ming Li, Juan Peng, Wen Gu, Xue-jun Guo   +3 more
doaj   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor

Frontiers in Immunology, 2021
Accumulating evidence indicates that nutrition can modulate the immune system through metabolites, either produced by host digestion or by microbiota metabolism.
Alba De Juan, Elodie Segura
doaj   +1 more source

Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction

, 2016
The prevalence of metabolic syndrome, a clustering of three or more risk factors that include abdominal obesity, increased blood pressure, and high levels of glucose, triglycerides, and high-density lipoproteins, has reached dangerous and costly levels ...
Shelley A. Tischkau, Cassie Jaeger
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Aryl hydrocarbon receptor is required for optimal B-cell proliferation [PDF]

, 2017
The aryl hydrocarbon receptor (AhR), a transcription factor known for mediating xenobiotic toxicity, is expressed in B cells, which are known targets for environmental pollutants.
Brink, Robert, Robert Brink, Stockinger, Brigitta, Brigitta Stockinger, Henderson, Colin J., Manolis Gialitakis, C Roland Wolf, Mauro Tolaini, Villa, Matteo, Colin J Henderson, Helena Ahlfors, Ahlfors, Helena, Gialitakis, Manolis, Tolaini, Mauro, Wolf, C. Roland, Matteo Villa   +15 more
core   +1 more source