Results 61 to 70 of about 1,983,941 (246)

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Identification of aryl hydrocarbon receptor (AhR)-active metabolites in firefighter urine samples

, 2022
Firefighter (FF) cancer rates are elevated due to chemical exposures, with strong evidence for contribution of receptor-mediated effects which are not adequately accounted for by known carcinogens.
von Hippel, Sophia
core   +2 more sources

Regulation of mouse small heat shock protein αb-crystallin gene by aryl hydrocarbon receptor. [PDF]

PLoS ONE, 2011
The stress-inducible small heat shock protein (shsp)/αB-crystallin gene is expressed highly in the lens and moderately in other tissues. Here we provide evidence that it is a target gene of the aryl hydrocarbon receptor (AhR) transcription factor.
Shuang Liu, Joram Piatigorsky
doaj   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

A study on the relationship of the activity of aryl hydrocarbon receptor and aryl hydrocarbon metabolic enzymes in peripheral blood and breast cancer

Zhongguo aizheng zazhi, 2014
Background and purpose: Previous studies showed activated aryl hydrocarbon receptor (AhR) might be involved in the development of breast cancer induced by polycyclic aromatic hydrocarbons (PHAs) and AhR which was regarded as transcription factors ...
王天航, 鲁英, 杨晓燕, 欧江华
doaj  

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells

Cell Reports, 2017
The local environment may affect the development and function of tissue-resident T regulatory cells (Tregs), which are crucial for controlling inflammation. Although the aryl hydrocarbon receptor (Ahr), an environmental sensor, is expressed by Tregs, its
Jian Ye, Ju Qiu, John W. Bostick, Aki Ueda, Hilde Schjerven, Shiyang Li, Christian Jobin, Zong-ming E. Chen, Liang Zhou   +8 more
doaj   +1 more source

Modeling of the Aryl Hydrocarbon Receptor (AhR) Ligand Binding Domain and Its Utility in Virtual Ligand Screening to Predict New AhR Ligands

, 2016
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor; the AhR Per-AhR/Arnt-Sim (PAS) domain binds ligands. We developed homology models of the AhR PAS domain to characterize previously observed intra- and interspecies ...
Sammy M. Khalil (2348380), Daniel C. Koch (315796), William H. Bisson (189115), Edmond F. O’Donnell (315794), Siva Kumar Kolluri (315800), Nancy I. Kerkvliet (315799), Ruben Abagyan (220938), Robert L. Tanguay (127737)   +7 more
core   +1 more source

Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR) [PDF]

Journal of Biological Chemistry, 2018
Cellular metabolites act as important signaling cues, but are subject to complex unknown chemistry. Kynurenine is a tryptophan metabolite that plays a crucial role in cancer and the immune system. Despite its atypical, non-ligand-like, highly polar structure, kynurenine activates the aryl hydrocarbon receptor (AHR), a PER, ARNT, SIM (PAS) family ...
Seung-Hyeon, Seok, Zhi-Xiong, Ma, John B, Feltenberger, Hongbo, Chen, Hui, Chen, Cameron, Scarlett, Ziqing, Lin, Kenneth A, Satyshur, Marissa, Cortopassi, Colin R, Jefcoate, Ying, Ge, Weiping, Tang, Christopher A, Bradfield, Yongna, Xing   +13 more
openaire   +2 more sources

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

The aryl hydrocarbon receptor (AhR) as a breast cancer drug target

Medicinal Research Reviews, 2019
AbstractBreast cancer is the most common cancer in women, with more than 1.7 million diagnoses worldwide per annum. Metastatic breast cancer remains incurable, and the presence of triple‐negative phenotypes makes targeted treatment impossible. The aryl hydrocarbon receptor (AhR), most commonly associated with the metabolism of xenobiotic ligands, has ...
Jennifer R. Baker, Jennette A. Sakoff, Adam McCluskey   +2 more
openaire   +3 more sources