Results 81 to 90 of about 1,983,941 (246)

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma

Nature Communications, 2018
Resistance to BRAF inhibitors limits their clinical benefit in melanoma patients. Here, the authors show that the Aryl hydrocarbon Receptor (AhR) is a key mediator of resistant genes and use resveratrol, an AhR antagonist, to revert resistance in ...
Sébastien Corre, Nina Tardif, Nicolas Mouchet, Héloïse M. Leclair, Lise Boussemart, Arthur Gautron, Laura Bachelot, Anthony Perrot, Anatoly Soshilov, Aljosja Rogiers, Florian Rambow, Erwan Dumontet, Karin Tarte, Alban Bessede, Gilles J. Guillemin, Jean-Christophe Marine, Michael S. Denison, David Gilot, Marie-Dominique Galibert   +18 more
doaj   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Aryl Hydrocarbon Receptor Nuclear Translocator in Hepatocytes Is Required for Aryl Hydrocarbon Receptor–Mediated Adaptive and Toxic Responses in Liver

, 2010
The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins (‘‘dioxins’’), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system.
Gregory D. Kennedy, Jacqueline A. Walisser, Susan M. Moran, Christopher A. Bradfield, Manabu Nukaya   +4 more
core   +1 more source

Aryl sulfonamides induce degradation of aryl hydrocarbon receptor nuclear translocator through crl4dcaf15 e3 ligase

, 2020
Aryl hydrocarbon receptor nuclear translocator (ARNT) plays an essential role in maintaining cellular homeostasis in response to environmental stress.
Byoung Chul Park, Jung Ae Kim, Min Yeong Yu, Ho Chul Shin, Sunhong Kim, Sung Ah Kim, Seung-Hyun Jo, Jin Hwa Cho, Jeong Hoon Kim, Sung Goo Park   +9 more
core   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility [PDF]

, 2017
The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in the molecular basis of essential hypertension ...
Churnosov, M. I., Bushueva, O. Y., Bulgakovaa, I. V., Polonikov, A. V., Freidin, M. B.   +4 more
core  

Aryl hydrocarbon receptor-mediated signal transduction

, 1997
The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix (bHLH) protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear translocator) forming a complex that binds to xenobiotic regulatory ...
Gustafsson, JA, Rowlands, JC, Jan-Åke Gustafsson, J. Craig Rowlands   +3 more
core   +1 more source

Oral microbiome and homeostatic regulation of periodontal health: From dysbiosis to precision intervention

VIEW, EarlyView.
Periodontal homeostasis is maintained by coordinated interactions between the oral microbiome and host. Dysbiosis disrupts this ecological balance and contributes to periodontal disease, whereas multi‐omics, artificial intelligence, and microbiome‐based interventions provide emerging opportunities for precision diagnosis, ecological restoration, and ...
Xu Liu, Lei Meng, Wenzhu Song, Peiyu Wang, Bin Liu, Shihui Liu, Qi He, Bing Sun, Wanheng Li, Zhiwei Guan, Rui Dong, Qiang Feng   +11 more
wiley   +1 more source

Purified Aryl Hydrocarbon Receptor Nuclear Translocator in Increasing Expression of the Aryl Hydrocarbon Receptor Complex

, 2015
The deletion construct of aryl hydrocarbon receptor (AhR), CΔ553 dimerizes with the deletion construct of aryl hydrocarbon receptor nuclear translocator (Arnt), CΔ418, forming the AhR/Arnt complex.
Chong, Jacklyn, Chan, William K., Cheung, Genevieve   +2 more
core  

Il meccanismo molecolare nella risposta cellulare alle diossine: AHR e suoi interattori [PDF]

, 2022
La proteina AhR (Aryl-hydrocarbon Receptor) è espressa in numerosi tessuti di mammifero. AhR è in grado di legare sostanze chimiche di natura antropica quali idrocarburi aromatici alogenati e policiclici o sostanze naturali di origine microbica ...
Carpentieri, Jacopo Amerigo
core