Journal of Pharmacological Sciences, 2009 Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor.
Noriko Sanada +4 more
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The aryl hydrocarbon receptor (AhR) as a drug target for cancer chemotherapy [PDF]
Current Opinion in Toxicology, 2017 The aryl hydrocarbon receptor (AhR) is overexpressed in some patients with different tumor types, and the receptor can be a negative or positive prognostic factor. There is also evidence from both in vivo and in vitro cell culture models that the AhR can exhibit tumor-specific pro-oncogenic and tumor suppressor-like functions and therefore can be ...
Stephen, Safe, Yating, Cheng, Un-Ho, Jin
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OSSERVAZIONI SULL’ATTIVAZIONE DEL RECETTORE ARILICO (AHR) IN CORRELAZIONE ALLA CONTAMINAZIONE AMBIENTALE DA METALLI PESANTI IN TUMORI SPONTANEI DI CANI DELLA REGIONE CAMPANIA. Correlation between Aryl hydrocarbon Receptor (AhR ) expression and environmental heavy metals contamination in canine tumors. [PDF]
, 2010 Osservazioni sull’attivazione del recettore arilico (Ahr) in correlazione alla contaminazione ambientale da metalli pesanti in tumori spontanei di cani della regione Campania.
Trapani, Francesca
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The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
Nature Communications, 2016 Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is
Matteo Villa +8 more
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Canine Coronavirus Activates Aryl Hydrocarbon Receptor during In Vitro Infection
Viruses, 2022 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts with substrates, including microbial metabolites.
Claudia Cerracchio +3 more
doaj +1 more source
Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR) [PDF]
Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast.
core +1 more source
Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon. [PDF]
Mol Nutr Food Res, 2021 ScopeThis study investigates the mechanism of action and functional effects of coffee extracts in colonic cells, on intestinal stem cell growth, and inhibition of dextran sodium sulfate (DSS)‐induced intestinal barrier damage in mice.Methods and ResultsAqueous coffee extracts induced Ah receptor (AhR) ‐responsive CYP1A1, CYP1B1, and UGT1A1 gene ...
Chapkin RS +12 more
europepmc +3 more sources
Genome-wide Mapping and Analysis of Aryl Hydrocarbon Receptor (AHR) and Aryl Hydrocarbon Receptor Repressor (AHRR) Bound Regions in MCF-7 Human Breast Cancer Cells [PDF]
, 2015 The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor best known for mediating the toxic actions of environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The aryl hydrocarbon receptor repressor (AHRR) is
Yang, Yang
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The Aryl Hydrocarbon Receptor and Tumor Immunity
Frontiers in Immunology, 2018 The aryl hydrocarbon receptor (AhR) is an important cytosolic, ligand-dependent transcription factor. Emerging evidence suggests the promoting role of the AhR in the initiation, promotion, progression, invasion, and metastasis of cancer cells. Studies on
Ping Xue +3 more
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, 2017 The aryl hydrocarbon receptor (AhR) is a ligand-dependent-activated transcriptional factor that regulates the metabolism of xenobiotic and endogenous compounds.
Lee, Chen-Chen;Yang, Wen-Hao;Li, Ching-Hao;Cheng, Yu-Wen;Tsai, Chi-Hao;Kang, Jaw-Jou +1 more
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