Results 11 to 20 of about 1,983,941 (246)

Antioxidant Functions of the Aryl Hydrocarbon Receptor [PDF]

Stem Cells International, 2016
The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but ...
Cornelia Dietrich
doaj   +4 more sources

The Aryl Hydrocarbon Receptor (AHR): Peacekeeper of the Skin. [PDF]

Int J Mol Sci
In the last decade, the aryl hydrocarbon receptor (AHR) has emerged as a critical peacekeeper for the maintenance of healthy skin. The evolutionary conservation of AHR implied physiological functions for this receptor, beyond the detoxification of man ...
Dawe HR, Di Meglio P.
europepmc   +5 more sources

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs). [PDF]

Int J Mol Sci, 2020
The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and dioxin-like compounds (DLCs).
Safe S, Jin UH, Park H, Chapkin RS, Jayaraman A.   +4 more
europepmc   +5 more sources

Aryl Hydrocarbon Receptor (AhR) Signaling in Colonic Cells and Tumors. [PDF]

Receptors (Basel), 2023
The aryl hydrocarbon receptor (AhR) is overexpressed in many tumor types and exhibits tumor-specific tumor promoter and tumor suppressor-like activity.
Safe S, Han H, Jayaraman A, Davidson LA, Allred CD, Ivanov I, Yang Y, Cai JJ, Chapkin RS.   +8 more
europepmc   +4 more sources

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis [PDF]

Cell Reports, 2018
Summary: Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a specific set of glial cells, known as ependymoglial cells.
Rossella Di Giaimo, Tamara Durovic, Pablo Barquin, Anita Kociaj, Tjasa Lepko, Sven Aschenbroich, Christopher T. Breunig, Martin Irmler, Filippo M. Cernilogar, Gunnar Schotta, Joana S. Barbosa, Dietrich Trümbach, Emily Violette Baumgart, Andrea M. Neuner, Johannes Beckers, Wolfgang Wurst, Stefan H. Stricker, Jovica Ninkovic   +17 more
doaj   +2 more sources

The Aryl-Hydrocarbon Receptor Protein Interaction Network (AHR-PIN) as Identified by Tandem Affinity Purification (TAP) and Mass Spectrometry [PDF]

Journal of Toxicology, 2013
The aryl-hydrocarbon receptor (AHR), a ligand activated PAS superfamily transcription factor, mediates most, if not all, of the toxicity induced upon exposure to various dioxins, dibenzofurans, and planar polyhalogenated biphenyls.
Dorothy M. Tappenden, Hye Jin Hwang, Longlong Yang, Russell S. Thomas, John J. LaPres   +4 more
doaj   +2 more sources

Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer. [PDF]

Cells, 2023
Indoleamine 2,3-dioxygenase 2 (IDO2) is a tryptophan-catabolizing enzyme and a homolog of IDO1 with a distinct expression pattern compared with IDO1. In dendritic cells (DCs), IDO activity and the resulting changes in tryptophan level regulate T-cell differentiation and promote immune tolerance.
Kado SY, Bein K, Castaneda AR, Pouraryan AA, Garrity N, Ishihara Y, Rossi A, Haarmann-Stemmann T, Sweeney CA, Vogel CFA.   +9 more
europepmc   +6 more sources

Aryl hydrocarbon receptor (AHR) functions in infectious and sterile inflammation and NAD⁺-dependent metabolic adaptation. [PDF]

Arch Toxicol, 2021
Aryl hydrocarbon receptor (AHR) research has shifted from exploring dioxin toxicity to elucidation of various physiologic AHR functions. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to exert cellular stress-mediated sterile ...
Bock KW.
europepmc   +2 more sources

The Role of the Aryl Hydrocarbon Receptor (AhR) and Its Ligands in Breast Cancer. [PDF]

Cancers (Basel), 2022
Breast cancer is a complex disease which is defined by numerous cellular and molecular markers that can be used to develop more targeted and successful therapies. The aryl hydrocarbon receptor (AhR) is overexpressed in many breast tumor sub-types, including estrogen receptor -positive (ER+) tumors; however, the prognostic value of the AhR for breast ...
Safe S, Zhang L.
europepmc   +3 more sources

Binding of Aryl Hydrocarbon Receptor (AhR) to AhR-interacting Protein [PDF]

Journal of Biological Chemistry, 2000
The aryl hydrocarbon receptor (AhR) has been shown to interact with an immunophilin-like molecule known as AhR-interacting protein (AIP) and to enhance AhR function. We show here that AIP associates with AhR homologues from mouse and fish, which can bind ligands such as dioxin, but nonligand binding homologues from Caenorhabditis elegans or Drosophila ...
David R. Bell, Alan Poland
openaire   +2 more sources