Results 21 to 30 of about 1,983,941 (246)
Role of the aryl hydrocarbon receptor (AhR) in lung inflammation [PDF]
Seminars in Immunopathology, 2013 Millions of individuals worldwide are afflicted with acute and chronic respiratory diseases, causing temporary and permanent disabilities and even death. Oftentimes, these diseases occur as a result of altered immune responses. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acts as a regulator of mucosal barrier function ...
Celine A, Beamer, David M, Shepherd
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Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
Nature Communications, 2021 Necrotizing enterocolitis (NEC) is a disease of prematurity requiring Toll-like receptor 4 (TLR4) activation on the gut epithelium. Here the authors show that the aryl hydrocarbon receptor (AHR) mediates NEC pathogenesis via effects on TLR4, and that ...
Peng Lu +12 more
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Alizarin as a New Activator of the Aryl Hydrocarbon Receptor Signaling Pathway
Natural Product Communications, 2022 Alizarin (1,2-dihydroxyanthraquinone) is a natural red dye extracted from the roots of Rubia cordifolia L. (family Rubiaceae). Alizarin has been used as a biological red stain for calcium.
Yin-Che Lu +7 more
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The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity
Frontiers in Immunology, 2021 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and exogenous origin, including environmental pollutants, tryptophan metabolites, and microbial ...
Maria Florencia Torti +3 more
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Cyproterone acetate acts as a disruptor of the aryl hydrocarbon receptor
Scientific Reports, 2021 Prostate cancer is a major cause of death in males. Cyproterone acetate (CPA), the steroidal anti-androgen for part of androgen deprivation therapy, may block the androgen-receptor interaction and then reduce serum testosterone through its weak anti ...
Chih-Shou Chen +8 more
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Nature Communications, 2022 Alcohol consumption promotes neutral fat accumulation in the liver. Here, the authors report that alcohol induces aryl hydrocarbon receptor AhR in the liver, and hepatocyte-specific AhR deletion protects against alcohol induced accumulation potentially ...
Yun Seok Kim +7 more
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Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases
Cells, 2021 Aryl Hydrocarbon Receptor (AhR) is an evolutionary transcription factor which acts as a crucial sensor of different exogenous and endogenous molecules Recent data indicate that AhR is implicated in several physiological processes such as cell physiology,
Maddalena Napolitano +5 more
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Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies [PDF]
Current Opinion in Toxicology, 2018 The aryl hydrocarbon receptor (AhR) binds structurally diverse ligands that vary from the environmental toxicant 2,3,7,8-tetrachlorodibenzo-B-dioxin (TCDD) to AhR- active pharmaceuticals and health-promoting phytochemicals. There are remarkable differences in the toxicity of TCDD and related halogenated aromatics (HAs) vs. health promoting AhR ligands,
Stephen, Safe +4 more
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The Evolving Role of the Aryl Hydrocarbon Receptor (AHR) in the Normophysiology of Hematopoiesis [PDF]
Stem Cell Reviews and Reports, 2012 In addition to its role as a toxicological signal mediator, the Aryl Hydrocarbon Receptor (AHR) is also a transcription factor known to regulate cellular responses to oxidative stress and inflammation through transcriptional regulation of molecules involved in the signaling of nucear factor-erythroid 2-related factor-2 (Nrf2), p53 (TRP53 ...
Stephan, Lindsey +1 more
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Deciphering the roles of aryl hydrocarbon receptor (AHR) in regulating carcinogenesis
Toxicology, 2023 Le récepteur aux hydrocarbures aryliques (AHR) est un récepteur dépendant d'un ligand qui appartient à la superfamille des facteurs de transcription basiques hélice-boucle-hélice (bHLH). L'activation de la voie de signalisation AHR canonique est connue pour induire l'expression des enzymes du cytochrome P450, facilitant le métabolisme de détoxification
Zhi Xiong Chong +4 more
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